Steven R. Goodman, Ph.D.
Education and Professional Affiliations
B.S., SUNY at Stony Brook
Ph.D., Biochemistry, St. Louis University Medical School
Postdoctoral Fellow, Harvard Medical School
Representative to the National Biomedical Caucus by the AACBNC
Overview
Dr. Steven Goodman has been working on the spectrin membrane skeleton for the past thirty years. He was the first to describe nonerythroid spectrin in 1981 and has since demonstrated spectrin functions as diverse as regulating synaptic transmission, intracellular calcium homeostasis, and DNA repair. He more recently has provided the first description of the erythrocyte proteome; described defects in the sickle cell RBC proteome; defined the molecular basis of the irreversibly sickled cell; and demonstrated a new spectrin function as a ubiquitin conjugating/ligating enzyme.
Dr. Goodman joined the UT Dallas faculty five years ago, coming from the University of South Alabama College of Medicine where he was Chair of the Department of Cell Biology and Neuroscience and Director of the NIH Comprehensive Sickle Cell Center. Dr. Goodman is the C.L. and Amelia A. Lundell Professor of Life Sciences and is an Adjunct Professor of Cell Biology at UT Southwestern Medical Center. Working collaboratively with Dr. George Buchanan and colleagues at UTSW, Dr. Goodman helped bring the first NIH Sickle Cell Center to Texas. Steve is the immediate Past President of the Association of Anatomy, Cell Biology, and Neurobiology Chairs. He serves on multiple Editorial Boards and is Editor-in-Chief of Experimental Biology and Medicine. The third edition of Dr. Goodman’s textbook, Medical Cell Biology, will be available in 2007.
Recent Publications (2005/06)
1. Riahi, M.H., Kakhniashvili, D.G., and Goodman, S.R. 2005. Ubiquitination of Red Blood Cell α-Spectrin Does Not Effect Heterodimer Formation. Am. J. Hematol. 78: 281-287.
2. Chang, T.L., Kakhniashvili, D.G, and Goodman, S.R. 2005. Spectrin’s E2/E3 Ubiquitin Conjugating/Ligating Activity is Diminished in Sickle Cells. Am. J. Hematol, 79:89-96.
3. Blake, C.A., Kakhniashvili, D.G., and Goodman, S.R. 2005. The Mouse Anterior Pituitary Gland: Analysis by Ion Trap Mass Spectrometry. Neuroendocrinology, 81: 229-243
4. Wu, S., Cioffi, E., Alvarez, D., Sayner, S., Chen, H., Cioffi, D., King, J., Creighton, J., Townsley, M., Goodman, S.R., and Stevens, T., 2005, Essential Role of a Ca2+ Selective, Store Operated Current (ISOC) in Endothelial Cell Permeability. Determination of the Vascular Leak Site. Circulation Res. 96: 856-863.
5. Hsu, J., Zimmer, W.E., and Goodman, S.R. 2005. Erythrocyte Spectrin’s Chimeric E2/E3 Ubiquitin Conjugating/Ligating Activity. Cellular and Molecular Biology 51: 187-193.
6. Kakhniashvili, D.G. Griko, N.B., Bulla Jr.,L.A. and S. R. Goodman, 2005, The Proteomics of Sickle Cell Disease: Profiling of Erythrocyte Membrane Proteins by 2D-DIGE and Tandem Mass Spectrometry. Exper. Biol. Med. 230: 787-792.
7. Cioffi, D.L., Wu, S., Alexeyev, M., Goodman, S.R., Zhu, M.X., and T. Stevens, 2005 Activation of the Endothelial Store-Operated Isoc Ca2+ Channel Requires Activation of Protein 4.1 with TRPC4. Circulation Res. I97: 1164-1170.
8. Hsu, J., and Goodman, S.R.,2005. Spectrin and Ubiquitination: A Review. Cellular and Molecular Biology 51: OL801-OL807.
9. Chou, J. Choudhary, P.K., and Goodman, S.R. 2006 Protein Profiling of Sickle Cell Versus Control RBC Core Membrane Skeletons by ICAT Technology and Tandem Mass Spectrometry. Cell Mol. Biol. Lett. 11: 326-337.
10. Goodman, S.R. and C.A. Blake, 2006 The Future of Interdisciplinary Research and Training: Defeating the Silo Guardians. Exp. Biol. & Med. 231: 1189-1191.
11. Medical Cell Biology, Third Edition, editor Steven R. Goodman, Academic Press, in press.
12. Joiner, C.H. and S.R. Goodman, 2006, Damage to the RBC Membrane in Sickle Cell Disease. Sickle Cell Disease In Press.
- Updated: February 6, 2006
