The molecular mechanisms that cause pain to become chronic; developing therapeutics to target these mechanisms
Dr. Theodore Price is one of the foremost researchers in understanding how neuronal plasticity alters the way the brain receives nociceptive information from the sensory system and how this relates to chronic pain in human patients. Dr. Price has discovered several novel targets that regulate the excitability of sensory neurons after injury and that mediate plasticity in the central nervous system that cause pain to become chronic. Dr. Price’s work has been published in numerous scientific journals and his research program has been supported by the National Institutes of Health and the Migraine Research Foundation. He serves as an editor for several leading industry journals and received the Patrick D. Wall Young Investigator Award from the International Association for the Study of Pain. Dr. Price also received the John C. Liebeskind Early Career Scholar Award from the American Pain Society, the Buhrmester Rising Star Award from UT Dallas, and has been named a permanent member of the NIH Somatosensory and Chemosensory Study Section. Dr. Price earned his bachelor’s degree from UT Dallas and his doctoral degree in pharmacology from the University of Texas Health Science Center at San Antonio.
Articles in Peer-Refereed Journals
Kim, J.V., Tillu, D.V., Quinn, T.L., Mejia, G.L., Shy, A., Asiedu, M.N., Murad, E., Schumann, A.P., Totsch, S.K., Sorge, R., Mantyh, P.W., Dussor, G., Price T.J. (2015) Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. Journal of Neuroscience, 35(16) 6307-6317.
Tillu, D.V., Hassler, S.N., Burgos-Vega, C., Quinn, T.L., Sorge, R.E., Dussor, G., Boitano, S., Vagner, J., Price, T.J. (2015) Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state. Pain, 156(5) 859-67.
Kaila, K., Price, T.J., Payne, J.A., Puskarjov, M., Voipio, J. (2014) Cation-chloride cotransporters in neuronal development, plasticity and disease. Nature Reviews Neuroscience, 15(10) 637-54.
Melemedjian, O.K., Asiedu, M.N., Tillu, D.V., Peebles, K., Yan, J., Ertz, N., Dussor, G., Price, T.J. (2010) IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. Journal of Neuroscience, 30(45) 15113-23.