School of Behavioral and Brain Sciences

Sven Kroener

Associate Professor

Research Interests

Physiology of the prefrontal cortex as it relates to schizophrenia and drug addiction

Curriculum Vitae

Contact

Email: [email protected]
Phone: 972-883-2039
Office: BSB_10.514
Campus Mail Code: BSB 14
Website: Cellular and Synaptic Physiology Lab

Biography

Dr. Sven Kroener is known for his research into animal models of schizophrenia and drug addiction. One line of inquiry in his lab investigates behavioral and electrophysiological changes in the prefrontal cortex that occur in a developmental model of schizophrenia which uses NMDA receptor antagonism to affect the function of GABAergic interneurons. Other projects look at vagus nerve stimulation (VNS) as a tool to increase extinction from drug seeking and to prevent relapse, and how alcohol addiction affects cognitive flexibility. All of these projects use a combination of behavioral, electrophysiological, and immunohistochemical techniques. The current work in Dr. Kroener’s lab expands on his previous research which examined dopamine modulation of prefrontal cortical networks and the role of interneurons in schizophrenia and drug addiction. Dr. Kroener is currently the principal investigator or co-investigator on three grants from the National Institutes of Health and the UT Brain Initiative, and he was previously responsible for four different extramural and intramural grants from NIH and UTD. Dr. Kroener earned his master’s and doctoral degrees at the Ruhr-University in Bochum, Germany.

Recent and Selected Representative Publications

Recent Articles in Peer-Refereed Journals

Phensy A, Driskill C, Lindquist K, Guo L, Jeevakumar V, Fowler B, Du H, Kroener S (2017) Antioxidant treatment in male mice prevents mitochondrial and synaptic changes in an NMDA receptor dysfunction model of schizophrenia. eNeuro. 4(4). pii: ENEURO.0081-17.2017. doi: 10.1523/ENEURO.0081-17.2017.

Childs JE, DeLeon J, Nickel E, Kroener S (2016) Vagus nerve stimulation reduces cocaine-seeking and alters plasticity in the extinction network. Learning Mem. 24(1):35-42. doi: 10.1101/lm.043539.116.

Beck SJ, Guo L, Phensy A, Tian J, Wang L, Tandon N, Gauba E, Lu L, Pascual J, Kroener S, Du H (2016) Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease. Nature Communications 7:11483. doi:10.1038/ncomms11483.

Jeevakumar V, Kroener S (2014) Ketamine administration during the second postnatal week alters synaptic properties of fast-spiking interneurons in the medial prefrontal cortex of adult mice. Cereb Cortex 26(3):1117-29. doi: 10.1093/cercor/bhu293.

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