PhD, Mount Sinai School of Medicine
Molecular and Biochemical Mechanisms of Synaptic Plasticity, Emotional Learning and Memory
My research interests are directed toward elucidating the molecular and cellular mechanisms of neuronal plasticity that govern emotional memory as well as identifying the causes and consequences of aberrant forms of plasticity that occur in psychiatric disorders, such as anxiety. Collectively my research utilizes a myriad of molecular, biochemical and behavioral approaches.
Some of the ongoing projects in my laboratory are:
Specialties: Pavlovian fear conditioning, memory consolidation and reconsolidation, AAV and Lenti virus production for in vivo delivery of recombinant transgenes, Gene expression analysis, Gene identification
Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala. Holehonnur R, Luong JA, Chaturvedi D, Ho A, Lella SK, Hosek MP, Ploski JE. BMC Neurosci. 2014 Feb 18;15(1):28. doi: 10.1186/1471-2202-15-28.
Amygdala nuclei critical for emotional learning exhibit unique gene expression patterns. Partin AC, Hosek MP, Luong JA, Lella SK, Sharma SA, Ploski JE. Neurobiol Learn Mem. 2013 Sep;104:110-21. doi: 10.1016/j.nlm.2013.06.015. Epub 2013 Jul 2.
The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. Ploski JE, Monsey MS, Nguyen T, DiLeone RJ, Schafe GE. PLoS One. 2011;6(8):e23760. doi: 10.1371/journal.pone.0023760. Epub 2011 Aug 22.