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School of Behavioral and Brain Sciences

Curriculum Vitae

Jonathan E. Ploski, PhD

 

Jonathan E. Ploski

Assistant Professor

School of Behavioral and Brain Sciences; Cognition and Neuroscience Program

Department of Molecular & Cell Biology

 

The University of Texas at Dallas

800 W. Campbell Rd., BSB 14

Richardson, TX 75080-3021

Phone: (972) 883-2014

email [email protected]

 

 

 

Area of Study: Molecular and Biochemical Basis of Emotional Learning and Memory

 

 

Overview of Education/Training Grant/Fellowship Funding
Education Peer-Reviewed Publications
Research Training Conference Abstracts
Teaching Experience Additional Professional Experience

 

 

 

 

 

 

 

 

 

Overview of Education/Training

 

INSTITUTION AND LOCATION DEGREE
(if applicable)
YEAR(s) FIELD OF STUDY
University at Buffalo, Buffalo, NY BS 5/98 Biological Sciences
Mount Sinai School of Med., NY, NY PhD 7/04 Biomedical Science
Yale Med. School, New Haven, CT Post-doc 7/04-8/06 Molecular Psychiatry
Yale University, New Haven, CT Post-doc 9/06-3/09 Behavioral Neuroscience

 

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Education

 

Mount Sinai School of Medicine of NYU

PhD Biomedical Science

New York NY 2004
Dissertation: The Nucleocytoplasmic Trafficking of Paired-type and Divergent Homeodomain Proteins
     
University at Buffalo Buffalo NY 1998
BS Biological Sciences

 

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Research Training

 

Associate Research Scientist

Postdoctoral Fellow

4/2009-5/2010

9/2006-3/2009

Yale University

Department of Psychology, New Haven CT

Advisor: Glenn E. Schafe, PhD

 
Area of Study: Emotional Learning and Memory
  • Examined the molecular and cellular basis of acquired fears focusing on the role of activity dependent gene expression within the amygdala during fear memory consolidation. Utilized a variety of behavioral and molecular biological techniques to identify genes involved in fear memory formation.
  • Identified novel genes associated with long-term potentiation and Pavlovian fear conditioning
  • Identified the proteins Arc/Arg3.1 and Npas4 as essential for fear memory consolidation within the amygdala
   
Postdoctoral Fellow 7/2004–8/2006

Yale University School of Medicine

Department of Psychiatry, New Haven CT Advisor: Ronald S. Duman, PhD

 
Area of Study: Molecular Basis of Antidepressant Response
  • Examined antidepressant-induced gene expression changes in the rodent brain from discrete laser microdissected portions of the hippocampus utilizing DNA microarray technology.
  • Identified gene expression profile differences among individual laser microdissected amygdala nuclei, brain structures involved in emotional regulation and fear learning, utilizing DNA microarray technology.
   
Graduate Student 9/1998–7/2004

Mount Sinai School of Medicine of NYU

Department of Gene and Cell Medicine, New York NY

Advisor: Aurelian Radu, PhD

 
Area of Study: Nucleocytoplasmic Transport of Macromolecules
  • Determined and characterized novel nucleocytoplasmic transport pathways for multiple karyopherins using in vivo and in vitro approaches
  • Characterized a novel nuclear localization sequence that specifically targets a particular family of homeodomain-containing proteins to the nucleus
  • Investigated whether naturally occurring mutations located within a newly identified NLS disrupt nuclear import and contribute to the diseases with which these mutations are associated
   
Research Assistant 6/1997–7/1998

Roswell Park Cancer Institute
Department of Cancer Genetics, Buffalo NY
Advisor: Peter Aplan, MD

 
Area of Study: Molecular Genetics of Pediatric Leukemia
  • Characterized the breakpoints that occur in the t(12;21)(p13;q22) translocation frequently associated with pre-B cell Acute Lymphoblastic Leukemia
  • Investigated the DNA fragmentation events that occur following cytotoxic chemotherapy in leukemic cell lines

 

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Teaching Experience

 

Assistant Professor

University of Texas at Dallas, Behavioral and Brain Sciences, Richardson, TX

  • Neuroscience Lab Methods (NSC 4353)
Fall 2016
  • Genetic Bioengineering (HCS 7372.091)
Summer 2016
  • Molecular Neuroscience (NSC 4362)
Spring 2016
  • Sem: Genes, Brain & Behavior (HCS 7372)
Spring 2016
  • Neuroscience Lab Methods (NSC 5353)
Fall 2015
  • Molecular Neuroscience (NSC 4362)
Spring 2015
  • Sem: Genes, Brain & Behavior (HCS 7372)
Spring 2015
  • Molecular Neuroscience (NSC 4362)
Fall 2014
  • Molecular Neuroscience (NSC 4362)
Spring 2014
  • Sem: Genes, Brain & Behavior (HCS 7372)
Spring 2014
  • Neuroscience Lab Methods (NSC 4353)
Fall 2013
  • Molecular Neuroscience (NSC 4362)
Spring 2013
  • Neuroscience Lab Methods (NSC 4353)
Spring 2013
  • Neuroscience Lab Methods (NSC 4353)
Fall 2012
  • Seminar in Molecular Neuroscience (NSC 4V90.001.12S)
Spring 2012
  • Neuroscience Lab Methods
Spring 2012
  • Seminar in Molecular Neuroscience (HCS 7372.001)
Spring 2011
  • Neuroscience Laboratory Methods (NSC 4353.001.11F)
Fall 2011
   
Adjunct Assistant Professor
Quinnipiac University, Departments of Psychology & Biological Sciences, Hamden CT  
  • Lecturer for Physiological Psychology 252

Spring 2010

  • Lecturer for Introduction to Psychology 101
Spring 2010
  • Lecturer for Physiological Psychology 252
Fall 2009
  • Lecturer for Physiological Psychology 252
Spring 2009
  • Lecturer for Brain & Behavior 351
Fall 2008
  • Instructor for two sections of Biology Laboratory 101
Fall 2008
  • Lecturer for Abnormal Psychology 272
Spring 2008
  • Instructor for three sections of Biology Laboratory 105
Fall 2007

 

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Grant/Fellowship Funding

 

Ongoing

Proposal Title: (RO1) — Neural Substrates of Contextual Memory in Fear Extinction

P.I.: Maren S; Co.I.: Ploski JE

Funding Agency: NIMH

Budget Period Dates: 04/01/2015 — 03/31/2017

Budget: $47,150 (Subcontract)

Proposal Title: (R21) — Generation of Viral Based Inducible and Cre Dependent Genome Editing Tools for Neuroscience

P.I.: Ploski JE Co.I.: Kim TH

Funding Agency: NIMH

Budget Period Dates: 07/01/2016 — 06/30/2018

Budget: $420,750

Proposal Title: Sub-millisecond Optically-triggered Compound Release to Study Real-time Brain Activity and Behavior

P.I.: Qin Z; Co.P.I.: Ploski JE

Funding Agency: NSF

Budget Period Dates: 08/01/2016 — 07/31/2020

Budget: $800,000

 
Completed

Proposal Title: (F32) — Role of Orphan Nuclear Receptor Nurr1 in Fear Conditioning P.I.: Ploski JE

P.I.: Ploski JE

Funding Agency: NIMH

Budget Period Dates: 09/30/2007 — 09/29/2008

Budget: $51,278

Proposal Title: (R21) Molecular Mechanisms of Reconsolidation Boundaries

P.I.: Ploski JE

Funding Agency: NIMH

Budget Period Dates: 08/10/2012 — 05/31/2015

Budget: $420,750

Proposal Title: (RO3) — Optimization of adeno-associated virus for the study of amygdala dependent learning and memory

P.I.: Ploski JE

Funding Agency: NIMH

Budget Period Dates: 09/01/2013 — 08/31/2015

Budget: $153,000

 

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Peer-Reviewed Publications

 

Review Jonathan Ploski's publications on Pubmed


 

Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. Holehonnur R, Phensy AJ, Kim LJ, Milivojevic M, Vuong D, Daison DK, Alex S, Tiner M, Jones LE, Kroener S, Ploski JE. J Neurosci. 2016 Sep 7;36(36):9490-504. doi: 10.1523/JNEUROSCI.1743-16.2016. PMID: 27605622

 

The Development of a Viral Mediated CRISPR/Cas9 System with Doxycycline Dependent gRNA Expression for Inducible In vitro and In vivo Genome Editing. de Solis CA, Ho A, Holehonnur R, Ploski JE. Front Mol Neurosci. 2016 Aug 18;9:70. doi: 10.3389/fnmol.2016.00070. eCollection 2016. PMID: 2758799

 

Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment. Banerjee A, Luong JA, Ho A, Saib AO, Ploski JE. Mol Autism. 2016 Feb 29;7:16. doi: 10.1186/s13229-016-0077-9. eCollection 2016. PMID: 26929812

 

Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioning de Solis CA, Holehonnur R, Banerjee A, Luong JA, Lella SK, Ho A, Pahlavan B, Ploski JE. Neurobiol Learn Mem. 2015 Oct;124:34-47. doi: 10.1016/j.nlm.2015.07.005. Epub 2015 Jul 13.

 

The production of viral vectors designed to express large and difficult to express transgenes within neurons. Holehonnur R, Lella SK, Ho A, Luong JA, Ploski JE. Mol Brain. 2015 Feb 24;8:12. doi: 10.1186/s13041-015-0100-7. PMID:25887710

 

Emotional modulation of synapses, circuits and memory. Ploski JE, McIntyre CK. Front Behav Neurosci. 2015 Feb 19;9:35. doi: 10.3389/fnbeh.2015.00035. eCollection 2015. No abstract available. PMID: 25745390

 

Abnormal emotional learning in a rat model of autism exposed to valproic acid in utero. Banerjee A, Engineer CT, Sauls BL, Morales AA, Kilgard MP, Ploski JE. . Front Behav Neurosci. 2014 Nov 12;8:387. doi: 10.3389/fnbeh.2014.00387. eCollection 2014. PMID: 25429264

 

Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala. Holehonnur R, Luong JA, Chaturvedi D, Ho A, Lella SK, Hosek MP, Ploski JE.  BMC Neurosci. 2014 Feb 18;15(1):28. doi: 10.1186/1471-2202-15-28.

 

Amygdala nuclei critical for emotional learning exhibit unique gene expression patterns. Partin AC, Hosek MP, Luong JA, Lella SK, Sharma SA, Ploski JE. Neurobiol Learn Mem. 2013 Sep;104:110-21. doi: 10.1016/j.nlm.2013.06.015. Epub 2013 Jul 2.

 

The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories. Ploski JE, Monsey MS, Nguyen T, DiLeone RJ, Schafe GE. PLoS One. 2011;6(8):e23760. doi: 10.1371/journal.pone.0023760. Epub 2011 Aug 22.

 

A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory.
Overeem KA, Ota KT, Monsey MS, Ploski JE, Schafe GE. Front Behav Neurosci. 2010 Feb 5;4:2. doi: 10.3389/neuro.08.002.2010. eCollection 2010.

 

Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala. Ploski JE, Park KW, Ping J, Monsey MS, Schafe GE. J Neurochem. 2010 Feb;112(3):636-50. doi: 10.1111/j.1471-4159.2009.06491.x. Epub 2009 Nov 12.

 

A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH. Ploski JE, Topisirovic I, Park KW, Borden KL, Radu A. Mol Cell Biochem. 2009 Dec;332(1-2):173-81. doi: 10.1007/s11010-009-0188-0. Epub 2009 Jul 9.

 

The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala. Ploski JE, Pierre VJ, Smucny J, Park K, Monsey MS, Overeem KA, Schafe GE. J Neurosci. 2008 Nov 19;28(47):12383-95. doi: 10.1523/JNEUROSCI.1662-08.2008.

 

The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase. Ota KT, Pierre VJ, Ploski JE, Queen K, Schafe GE. Learn Mem. 2008 Oct 2;15(10):792-805. doi: 10.1101/lm.1114808. Print 2008 Oct.

 

Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. Gourley SL, Wu FJ, Kiraly DD, Ploski JE, Kedves AT, Duman RS, Taylor JR.
Biol Psychiatry. 2008 Feb 15;63(4):353-9. Epub 2007 Sep 24.

 

Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer. Ploski JE, Newton SS, Duman RS. J Neurochem. 2006 Nov;99(4):1122-32. Erratum in: J Neurochem. 2007 May;101(3):863-4.

 

Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. Ploski JE, Shamsher MK, Radu A. Mol Cell Biol. 2004 Jun;24(11):4824-34.

 

Characterization of DNA fragmentation events caused by genotoxic and non-genotoxic agents. Ploski JE, Aplan PD. Mutat Res. 2001 Feb 20;473(2):169-80.

 

ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene. Thandla SP, Ploski JE, Raza-Egilmez SZ, Chhalliyil PP, Block AW, de Jong PJ, Aplan PD. Blood. 1999 Jan 1;93(1):293-9.

 

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Conference Abstracts (Selected)

 

Goode TD, J. Jin J, Holehonnur R, Ploski JE, and Maren S. Combinatorial DREADD silencing of ventral hippocampal neurons projecting to infralimbic cortex prevents fear renewal, (Society for Neuroscience Abstract, Chicago 2015).

 

de Solis CA, Ho A, Morales AA, and Ploski JE. Identification of mRNAs that localize to the distal dendrites of the molecular layer of the dentate gyrus following high frequency stimulation of the perforant path, (Society for Neuroscience Abstract, Chicago 2015).

 

Holehonnur R, Phensy A, Milivojevic M, Kim LJ, Daison DK, Vuong DT, Tiner M, Jones LE, Kroener S and Ploski JE. Increasing the GluN2A/GluN2B ratio within neurons of the mouse basal and lateral amygdala inhibits the modification of an existing fear memory trace. MCCS Chicago, Oct 2015.

 

de Solis CA, Holehonnur R, Banerjee A, Luong JA, Lella SK, Ho A, Pahlaven B, and Ploski JE. Viral delivery of RNAi to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioning. Pavlov Society Meeting, Portland Oregon Sept 2015.

 

Holehonnur R, Kim LJ, Jones LE, Daison DK, Vuong DT, Khakoo SF and Ploski JE. Overexpression of GluN2A or GluN2B within neurons of the mouse basal and lateral amygdala alters amygdala dependent mnemonic processing, (Society for Neuroscience Abstract, Chicago 2015).

 

de Solis CA, Holehonnur R, Banerjee A, Luong JA, Lella SK, Ho A, Pahlaven B, and Ploski JE. “Viral delivery of RNAi to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioning” MCCS Washington DC, Nov 2014.

 

Banerjee J, Luong JA, Ho A, Morales AA, Sauls BL, and Ploski JE. “The molecular basis of altered emotional learning in an environmentally induced animal model of Autism” MCCS Washington DC, Nov 2014.

 

Holehonnur R, Ho A, Luong JA, Lella SK, and Ploski JE. “The development of viral vectors designed to express GluN2 subunits for the study of amygdala dependent mnemonic processing” MCCS Washington DC, Nov 2014.

 

Hosek MP, Ho H, Luong JA, de Solis C, Banerjee A, Holehonnur R, Chaturvedi D, Pahlavan B, Jones LE, and Ploski JE “Adeno-Associated Viral Serotypes Differentially Transduce Neurons within the Rat Basolateral Amygdala and the Central Nucleus of the Amygdala, but not neuronal subtypes” MCCS Washington DC, Nov 2014.

 

Banerjee A, Luong JA, Morales A, Ho A, Sauls BL, Ploski JE. “The molecular basis of altered emotional learning in an environmentally induced animal model of Autism.” SFN Washington DC, Nov 2014.

 

Banerjee A , Luong JA, Lella SK, Sauls BL, Engineer C, Kilgard MP, Ploski JE. "Perturbations of emotional learning in an animal model of environmentally induced Autism." Pavlov Society Meeting, Austin TX, Sept 2013.

 

Hosek MP, Partin AC, Luong JA, Lella SK, Sharma SA, Ploski JE. 2013. "Amygdala nuclei critical for Pavlovian fear conditioning exhibit unique gene expression patterns." Pavlov Society Meeting, Austin TX, Sept 2013.

 

Holehonnur R, Luong JA, Chaturvedi D, Ho A, Lella SK, Hosek MP, Ploski JE. "Adeno-Associated Viral Serotypes Produce Differing Titers and Differentially Transduce Glutamatergic Excitatory Neurons within the Rat Basolateral Amygdala." Pavlov Society Meeting, Austin TX, Sept 2013.

 

Banerjee A , Luong JA, Lella SK, Sauls BL, Engineer C, Kilgard MP, Ploski JE. "Perturbations of emotional learning in an animal model of environmentally induced Autism." SFN San Diego CA, Nov 2013.

 

Holehonnur R, Luong JA, Chaturvedi D, Ho A, Lella SK, Hosek MP, Ploski JE. "Adeno-Associated Viral Serotypes Produce Differing Titers and Differentially Transduce Glutamatergic Excitatory Neurons within the Rat Basolateral Amygdala." SFN San Diego CA, Nov 2013.

 

Ploski JE, Nguyen T, Monsey MS, Dileone RJ, Schafe GE A role for Npas4 in amygdala dependent emotional learning. Program No. 608.1. 2010. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010.

 

Ploski JE, Park K, Schafe GE, Identification of genes induced by fear conditioning in the lateral amygdala. Program No. 294.7. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008.

 

Ploski JE, Schafe GE, Gene expression analysis of long-term potentiation in the lateral amygdala.  Program No. 91.8. Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007.

 

Ploski JE, Newton SS, Duman RS, Differential gene expression between amygdala subnuclei. Program No. 291.10.  Atlanta, GA: Annual Meeting of the Society for Neuroscience, 2006.

 

Ploski JE, Duman RS, Sathyanesan SN, Antidepressant-Induced gene expression changes in the hippocampal subfields – Feasibility of laser microdissection and RNA amplification. Program No. 915.4.  Washington, DC: Annual Meeting of the Society for Neuroscience, 2005.

 

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Additional Professional Experience

 

Manuscript Reviewer

Reviewed papers for the journals:

  • Journal of Neuroscience
  • Molecular Autism
  • PlosOne
  • Journal of Neuroendocrinology
  • Genomics
  • Neural Plasticity
  • Journal of Biological Chemistry
  • Behavioral Brain Research
  • Neurobiology of Learning & Memory
  • Neuroscience Letters
  • Stem Cell Research & Therapy
  • Frontiers in Behavioral Neuroscience
  • Progress in Neurobiology
  • Learning & Memory
  • Molecular Brain
  • The International Journal of Neuropsychopharmacology

 

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