Antonello Bonci, M.D. Colloquium on Drug Addiction, "Optogenetic Modulation of the Limbic System: Implications for Substance Use Disorders"
The School of Behavioral and Brain Sciences
presents: Antonello Bonci, M.D., University of California, San Francisco. The focus of Dr. Bonci's research, chronic exposure to drug abuse causes several cellular and behavioral adaptations such as tolerance, dependence, and sensitization.
Chronic exposure to drugs of abuse causes several cellular and behavioral adaptations such as tolerance, dependence, and sensitization. The main goal of my laboratory is to understand the synaptic properties of neurons in brain areas relevant to drug addiction, such as the ventral tegmental area (VTA) and the nucleus accumbens (NAcc). We have recently demonstrated that the VTA principal neurons are able to express various forms of synaptic plasticity, such as long-term potentiation (LTP) and long-term depression (LTD).
One of the aims of my research is to establish a correlation between excitatory amino acid receptors, and the long-term changes that are produced by chronic administration of drugs of abuse such as ethanol, cocaine and morphine. This will allow us to examine changes produced at the synaptic level by the chronic treatment with these drugs, and possibly open new avenues for potential therapeutic strategies.
Please join BBS for coffee at 9:15am. Refreshments following presentation. For more information regarding Dr. Bonci's research, see Antonello Bonci, M.D.