The Department of Molecular and Cell Biology presents Qihong Huang, M.D., Ph.D., Associate Professor, Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA.
Presentation : Metastasis, the spread of cells from a primary tumor to distant organs, followed by growth of secondary tumors, is responsible for most cancer deaths. Metastasis occurs via a specific series of steps, starting with local invasion, followed by entrance of cancer cells into the blood stream, survival in the circulation, exit from blood vessels, initiation and maintenance of micrometastatic growth at distant sites, and finally vascularization of resulting tumors. All these steps must be successfully completed in order to produce macrometastases.
In spite of the clinical importance of metastasis, much remains to be learned about the biology of the process. The identification and characterization of molecules that control this process is therefore critical to our understanding of the mechanisms of cancer dissemination.
We applied a functional genomics approach to cell-based assays and animal models of metastasis in order to identify genes that regulate metastasis process. The discovery and characterization of these genes will be discussed.
Refreshements will be served in RL3.204 at 3:45PM