11:30 a.m. - 12:30 p.m. Location: SLC 1.204
Department of Mathematics
University of South Carolina
Mathematical Models of Chromosomal DNA in Yeast Cells
A genome is a complete copy of the entire set of genetic material that makeup a specific organism. The genome of eukaryotes is distributed into chromosomes. For example, the human genome (actually, two copies of it) is divided among 23 pairs of chromosomes. Chromosomes are made up of DNA, whose main function is to carry genetic information. All organisms, from bacteria to humans, face the daunting task of replicating, packaging, and segregating up to two meters of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell.
Although many of the chemical processes that take place during cell division and interphase have been detailed, our understanding of the physical and topological properties of chromosomes during these stages of the cell cycle is still far from conclusive. It is widely recognized that both theoretical and experimental breakthroughs are in order before a satisfactory picture can be reached.
In this talk we highlight our efforts to develop mathematical models of chromosomal DNA using principles from polymer physics, anchored in our current biological understanding, closely guided by and benchmarked against experimental data.
Sponsored by the Department of Mathematical Sciences
John Zweck, 972-883-6699
Questions? Email me.