10:45 a.m. - 12 p.m. Location: ECSS 2.102
Ravi V. Bellamkonda
Department of Biomedical Engineering
Vinik Dean of Engineering
"Engineering Strategies for Nerve Repair and Brain Tumor Therapy"
Control of cell migration is important for healing of damaged tissues; on the flip side, cell invasion is at the root of the challenge that clinicians face in treating brain tumors. In his talk, Bellamkonda discusses ongoing work in his laboratory, which includes: exploring the use of thin film mediated topographical cues to enable efficient and controlled migration of cells; in the peripheral nerve context, induction of Schwann cell migration into critically sized nerve gaps that enables bridging of long nerve gaps; and immunoengineering peripheral nerve repair.
In the context of brain tumors, Bellamkonda is designing novel devices to control the invasion of brain tumors along paths that are specified using topographical guidance of brain tumors in vivo. Bellamkonda demonstrates, for the first time to his knowledge, that topographical cues presented by thin films enable moving a primary tumor from an intracortical region to an extracortical hydrogel sink where the tumor cells are killed. This novel approach of bringing the tumor to the drug rather than the drug to the tumor is enabled by the ability to design constructs that enable controlled, directional migration of invasive brain tumors.
Ravi Bellamkonda is the Vinik Dean of the Pratt School of Engineering at Duke University. Prior to becoming dean, Bellamkonda served as the Wallace H. Coulter Professor and chair of the Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. He is committed to fostering transformative research and pedagogical innovation as well as programs that create an entrepreneurial mindset amongst faculty and students.
A trained bioengineer and neuroscientist, Bellamkonda holds an undergraduate degree in biomedical engineering. His graduate training at Brown University was in biomaterials and medical science (with Patrick Aebischer), and his post-doctoral training at Massachusetts Institute of Technology focused on the molecular mechanisms of axon guidance and neural development (with Jerry Schneider and Sonal Jhaveri). His current research explores the interplay of biomaterials and the nervous system for neural interfaces, nerve repair and brain tumortherapy.
From 2014 to 2016, Bellamkonda served as president of the American Institute for Biological and Medical Engineering (AIMBE), the leading policy and advocacy organization for biomedical engineers with representation from industry, academia and government. Bellamkonda’s numerous awards include the Clemson Award for Applied Research from the Society for Biomaterials, EUREKA award from National Cancer Institute (National Institutes of Health), CAREER award from the National Science Foundation and Best Professor Award from the Georgia Tech Biomedical Engineering student body.
Please visit engineering.utdallas.edu/lecture for more information.
We look forward to seeing everyone in the TI Auditorium!
(Refreshments at 10:45 AM)