Department of Chemistry

School of Natural Sciences and Mathematics

Jung-Mo Ahn
Associate Professor
BSB 11.538 (Research)
BE 3.312 (Teaching)
972-883-2917
[email protected]

Jung-Mo Ahn , Ph.D.

Bio-Organic and Medicinal Chemistry

Research Group

Ahn Lab Homepage

Education

B.S., Seoul National University (1992)
M.S., Seoul National University (1994)
Ph.D., University of Arizona (2000)
Postdoctoral Associate, The Scripps Research Institute (2001–04)

Research Description

The central theme of my research is to understand the chemistry and biology of peptides and proteins and to develop new approaches for manipulating these properties with purposefully designed small organic molecules. We employ chemical synthesis and combinatorial chemistry as well as spectroscopic and biophysical methods to accomplish these aims. Projects include:

  • Rational design of small organic molecules for mimicking protein secondary structures
  • Inhibition of key protein-protein interactions in various cancer models

Structure-based design of LXXLL peptidomimetics for inhibiting androgen receptor from interacting with its coregulator proteins in prostate cancer model

Structure-based design of LXXLL peptidomimetics for inhibiting androgen receptor from interacting with its coregulator proteins in prostate cancer model

Selected Publications

"Facile synthesis of benzamides to mimic an α-helix." Ahn, J.-M., Han, S.-Y. Tetrahedron Lett. (2007) 48: 3543-3547.

"Novel Amphiphilic Alpha-Helix Mimetics Based on a Bis-Benzamide Scaffold." Marimganti, S., Cheemala, M.N., Ahn, J.-M., Org. Lett. (2009) 11:4418-4421.

"Development of potent GLP-1 agonists with high enzyme stability by introducing multiple lactam bridges." Murage, E.N., Gao, G., Bisello, A., Ahn, J.-M., J. Med. Chem. (2010) 53:6412-6420.

"Solid-phase synthesis of tris-benzamides as alpha-helix mimetics." Lee, T.-K., Ahn, J.-M., ACS Comb. Sci. (2011) 13:107-111.

"Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer." Ravindranathan, P., Lee, T.-K., Yang, L., Centenera, M.M., Butler, L., Tilley, W.D., Hsieh, J.-T., Ahn, J.-M., Raj, G.V. Nature Communications (2013) 4:1923, doi:10.1038/ncomms2912.

"Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications." Manandhar, B., Ahn, J.-M., J. Med. Chem. (2015) 58: 1020-1037. doi: 10.1021/jm500810s.

  • Updated: January 18, 2017