Department of Chemistry

School of Natural Sciences and Mathematics

Sheena D'Arcy Ph.D.

Biochemistry and Structural Biology

Education

  • B.S., Biochemistry and Biology, University of Sydney, Australia (2003)
  • Ph.D., Structural Biology, University of Cambridge, United Kingdom (2008)
  • Postdoctoral Fellow, Colorado State University, United States of America

Research Description

Our research looks at the molecular basis of enhancer function in cell-specific gene expression. We study large protein assemblies that influence chromatin dynamics. We use biochemical, structural and in vivo approaches including x-ray crystallography and hydrogen-deuterium exchange coupled to mass spectrometry. Our research has implications for cancer treatment and regenerative medicine.

Selected Publications

  • D’Arcy, S., Martin, K.W., Panchenko, T., Chen, X., Bergeron, S., Stargell, L.A., Black, B.E., Luger, K. Chaperone Nap1 Shields Histone Surfaces used in a Nucleosome and can put H2A-H2B in an Unconventional Tetrameric Form. Mol Cell, 2013, 51(5): 662-77
  • Elsässer, S.J., D’Arcy, S. Towards a Mechanism for Histone Chaperones. Biochim Biophys Acta, 2013, 1819(3-4): 211-21
  • Hieb, A.R., D’Arcy, S., Kramer, M.A., White, A.E., Luger, K. Fluorescence Strategies for High-throughput Quantification of Protein Interactions. Nucleic Acids Res, 2012, 40(5): e33
  • D’Arcy, S., Luger, K. Understanding Histone Acetyltransferase Rtt109 Structure and Function: How Many Chaperones does it Take? Curr Opin Struct Biol, 2011, 21(6): 728-34
  • D’Arcy, S., Davies, O.R., Blundell, T.L., Bolanos-Garcia, V.M. Defining the Molecular Basis of BubR1 Kinetochore Interactions and Anaphase-Promoting Complex/Cyclosome (APC/C)-Cdc20 Inhibition. J Biol Chem, 2010, 285(19): 14764-76
  • Updated: August 31, 2015