Jiyong Lee, Ph.D.
B. S. 1999, Yonsei University
M. S. 2001, Yonsei University (Advisor: Injae Shin, Ph.D.)
Ph.D. 2009, UT Southwestern Medical Center (Advisor: Thomas Kodadek, Ph.D.)
PostDoc. 2012, The Scripps Research Institute (Advisor: Jeffery W. Kelly, Ph.D.)
My research goal is to develop chemical biology technologies and small molecules that will probe the biophysical/biochemical or cellular factors that regulate protein aggregation to elucidate the molecular mechanisms underlying their toxicity and functions. This will lead to the invention of new therapeutic / diagnostic / imaging strategies for the protein aggregation-associated diseases such as Alzheimer’s disease, Parkinson’s disease and particular cancers. In project 1, we will develop a novel target-specific chemical labeling technology by which the dynamic interactomes of a target protein can be identified with temporal resolution. Comparison of interactomes under various pathological conditions will reveal disease-associated interactomes. In project 2, we will develop a tool to detect different aggregation assembly states in amyloidogenesis pathways. This will be accomplished by identifying distinct sets of ligands (ligandome) that bind to different aggregation assembly states by high-throughput screening of combinatorial chemical libraries. Comparing ligandomes between healthy and diseased samples will lead to an understanding of physiological conditions under which toxic or functional aggregates are formed.
Lee, J., Culyba, E. K., Powers, E. T., Kelly, J. W., Amyloid-β forms fibrils by nucleated conformational conversion of oligomers , Nature Chemical Biology, 2011, 7, 602-609.
* Featured in Nature Chemical Biology News and Views: “FlAsH illuminates Aβ aggregation”, by Tiago F Outeiro.
*Evaluated in Faculty of 1000 by Alan Saghatelian.
Lee, J., Udugamasooriya, D. G., Lim, H-S., Kodadek, T., Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates, Nature Chemical Biology, 2010, 6(4), 258-260.
* Evaluated in Faculty of 1000 by Divya Krishnamurthy, Amy Barrios, and Ross Weatherman.
Lee, J., Reddy, M. M., Kodadek, T., Discovery of an orexin receptor positive potentiator, Chemical Science, 2010, 1(1), 48-54.
* Featured as an inside cover article.
- Updated: December 10, 2012