A. Dean Sherry , Ph.D.
Cecil and Ida Green Distinguished Chair in Systems Biology #1, Professor of Chemistry
Director, Advanced Imaging Research Center, U.T. Southwestern
MRI contrast agents; biomedical NMR
Research Group
Education
B.S., Wisconsin State University (1967): Chemistry
Ph.D., Kansas State University (1971): Physical/Inorganic Chemistry
NIH Postdoctoral Associate, New Mexico State University (1971–72)
Affiliations
Department of Radiology, U.T. Southwestern; Director
Advanced Imaging Research Center, U.T. Southwestern Medical Center, Dallas
Research Description
Our chemistry group at UT-Dallas is involved in the design of novel MR imaging agents that are responsive to physiology and metabolism.
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High relaxivity Gd3+-based agents that respond to binding events in vivo.
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Slow water exchange paramagnetic complexes that introduce MR contrast by a novel mechanism called chemical exchange saturation transfer (CEST). Paramagnetic CEST agents are now widely referred to a PARACEST agents.
Selected Publications
Woessner, D.E.; Zhang, S.; Merritt, M.E.; Sherry, A.D. “A numerical solution of the Bloch equations provides insights into the optimal design of PARACEST agents for MRI”, Magn. Reson. Med. (2005) 53: 790-799.
Zhang, S.; Jiang, X.; Sherry, A.D. “Modulation of the Lifetime of Water Bound to Lanthanide Metal Ions in Complexes with Ligands Derived from 1,4,7,10-Tetraazacyclododecane Tetraacetate (DOTA)”, Helv. Chim. Acta (2005) 88: 923-935.
- Updated: December 15, 2006
