The Sherry Lab

Professor of Chemistry

Biographical Sketch

Cecil and Ida Green Distinguished Chair in Systems Bioscience
Professor of Chemistry
Director, Advanced Imaging Research Center, UT-Southwestern
Professor of Radiology, UT-Southwestern

Education

B. Sc., Chemistry, Wisconsin State University, LaCrosse, 1967
Ph. D., Inorganic Chemistry, Kansas State University, 1971

Fields of Research Specialization

Biomedical magnetic resonance techniques, applications of 13C & 2H NMR to study intermediary metabolism, lanthanide based MRI contrast agents, biologically responsive imaging agents and lanthanide-macrocyclic complexes.

Employment History

1971-1972 National Institutes of Health Postdoctoral Fellow, New Mexico State University
1972-1976 Assistant Professor, University of Texas at Dallas
1975-1980 Visiting Staff Member, Los Alamos Scientific Laboratories
1976-1982 Associate Professor, University of Texas at Dallas
1979-1990 Head, Programs in Chemistry, University of Texas at Dallas
1982-pres. Professor of Chemistry, University of Texas at Dallas
1983-1984 NIH Senior Fellow, University of Texas Southwestern Medical Center, Dallas
1991-pres. Professor of Radiology, University of Texas Southwestern Medical Center, Dallas
2005-pres. Director, Advanced Imaging Research Center, UT-Southwestern Medical Center

Awards, Fellowships and Current Memberships

NSF Research Trainee, 1970-1971, Kansas State University
NIH Postdoctoral Fellow, 1971-1972, New Mexico State University
AWU-AEC Summer Faculty Fellowship, 1975, Los Alamos Scientific Lab.
NIH Senior Fellow, 1983-1984, University of Texas Southwestern Medical Center, Dallas
W.T. Doherty Award, 1990, DFW Section of the American Chemical Society
UT-Dallas Chancellor's Council Outstanding Teaching Award, 1994
American Chemical Society, Phi Kappa Phi, Phi Lambda Upsilon
Biophysical Chemistry (BBCB) Study Section Member, 1999-2003
Scientific Founder, Macrocyclics, Inc.

Recent Publication Highlights (from 290)

“A Paramagnetic CEST Agent for Imaging Glucose by MRI”, S. Zhang, R. Trokowski & AD Sherry, J. Amer. Chem. Soc., 125, 15288-15289 (2003).

“Analytical Solutions for 13C Isotopomer Analysis of Complex Metabolic Conditions: Substrate Oxidation, Multiple Pyruvate Cycles and Gluconeogenesis” AD Sherry, FMH Jeffrey & CR Malloy, Metabolic Engineering, 6, 12-24 (2004).

“Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative”, ES Jin, JG Jones, M Merritt, SC Burgess, CR Malloy & AD Sherry, Analy. Biochem., 327, 149-155 (2004).

“Compartmentation of Glycolysis and Glycogenolysis in the Perfused Rat Heart”, RA Carvalho, N Anousis, P Zhao, CR Malloy & AD Sherry, NMR Biomed., 17, 51-59 (2004).

“Glucose Production Pathways in Patients with HIV-Associated Lipodystrophy by 2H and 13C NMR of Plasma and Urine”, BC Weis, D Margolis, SC Burgess, ME Merritt, H Wise, AD Sherry & CR Malloy, Magn. Reson. Med., 51, 649-654 (2004).

“A 13C Isotopomer Kinetic Analysis of Cardiac Metabolism: Influence of Altered Cytosolic Redox and Extracellular [Ca2+]”, RA Carvalho, TB Rodrigues, P Zhao, FMH Jeffrey, CR Malloy & AD Sherry, Amer. J. Physiol., 287, H889-H895 (2004).

“Solution Dynamics and Stability of Lanthanide(III) S-2-(p-nitrobenzyl)DOTA Complexes”, M Woods, Z Kovacs, R Kiraly, E Brücher, S Zhang & AD Sherry, Inorg. Chem., 43, 2845-2851 (2004).

“Synthesis, Relaxometric and Photophysical Properties of a New pH Responsive MRI Contrast Agent: The Effect of Other Ligating Groups on Dissociation of a p-Nitrophenolic Pendant Arm”, M Woods, GE Kiefer, S Bott, A Castillo-Muzquiz, C Eshelbrenner, L Michaudet, K McMillan, SDK Mudigunda, D Ogrin, G Tircsó, S Zhang, P Zhao & AD Sherry, J. Amer. Chem. Soc., 126, 9248-9256 (2004).

“Biochemical Mechanism of Lipid-Induced Impairment of Glucose-Stimulated Insulin Secretion and Reversal with a Malate Analogue”, A Boucher, D Lu, SC Burgess, S Telemaque-Potts, MV Jensen, H Mulder, M-Y Wang, RH Unger, AD Sherry & CB Newgard, J. Biol. Chem., 279, 27263-27271 (2004).

“Understanding of Basic Mechanisms of -Cell Function and Survival: Prelude to New Diabetes Therapies”, CB Newgard, HE Hohmeier, D Lu, MV Jensen, VV Tran, G Chen, SC Burgess, & AD Sherry, Cell Biochem. & Biophysics, 40, 159-168 (2004).

“Toward the Design of MR Agents for Imaging -cell Function”, M Woods, S Zhang & AD Sherry, Curr. Med. Chem. – Immun., Endocrine. & Metabolic Agents, 4, 349-369 (2004).

“Impaired TCA cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase”, SC Burgess, N Hausler, M Merritt, C Storey, A Milde, S Koshy, J Lindner, MA Magnuson, CR Malloy & AD Sherry, J. Biol Chem., 279, 48941-48949 (2004).

“Cyclen-based phenylboronate ligands and their Eu3+- complexes for sensing glucose by MRI”, R Trokowski, S Zhang & AD Sherry, Bioconj. Chem., 15, 1431-1440 (2004).

“A numerical solution of the Bloch equations provides insights into the optimal design of PARACEST agents for MRI”, DE Woessner, S Zhang, ME Merritt & AD Sherry, Magn. Reson. Med., 53, 790-799 (2005).

“Modulation of the Lifetime of Water Bound to Lanthanide Metal Ions in Complexes with Ligands Derived from 1,4,7,10-Tetraazacyclododecane Tetraacetate (DOTA)”, S Zhang, X Jiang & AD Sherry, Helv. Chim. Acta, 88, 923-935 (2005).

“Metabolic Networks in the Liver by 2H and 13C NMR” In Metabolomics by In Vivo NMR, Edited by RG Shulman & DA Rothman, John Wiley & Sons, Ltd., West Sussex, England, Chapter 12, pp 159-174 (2005).

“Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart”, X Yu, SC Burgess, H Ge, KK Wong, RH Nassem, DJ Garry, AD Sherry, CR Malloy, JP Berger, C Li, Proc Natl Acad Sci USA, 102, 1767-1772 (2005).

“Effect of Murine Strain on Metabolic Pathways of Glucose Production after Brief or Prolonged Fasting” SC Burgess, FMH Jeffrey, C Storey, A Milde, N Hausler, ME Merritt, H Mulder, C Holm, AD Sherry & CR Malloy, Amer. J. Physiol., 289, E53-E61 (2005).

“Differing Mechanisms of Hepatic Glucose Overproduction in Triiodothyronine-Treated Rats versus Zucker Diabetic Fatty Rats by NMR Analysis of Plasma Glucose” ES Jin, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Amer. J. Physiol., 288, E654-E662 (2005).

“Comparison of [3,4-13C2]Glucose to [6,6-2H2]Glucose as a Tracer for Glucose Turnover by Nuclear Magnetic Resonance” ES Jin, JG Jones, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Magn. Reson. Med., 53, 1479-1483 (2005).

“On Resonance Low B1 Pulses for Imaging of the Effects of PARACEST Agents”, E Vinogradov, S Zhang, A Lubag, JA Balschi, AD Sherry and RE Lenkinski, J. Magn. Reson., 176, 54-63 (2005).

“Water Exchange is the Key Parameter in the Design of Next-Generation MRI Agents”, AD Sherry, S Zhang & M Woods, ACS Symposium Series 903 (2005).

“Selective Sensing of Zn2+ with a Novel PARACEST Agent”, R Trokowski, J Ren, FK Kalman & AD Sherry, Angew. Chem. Int. Ed., 44, 6920-6923 (2005).

“MRI Thermometry Based on PARACEST Agents”, S Zhang, CR Malloy & AD Sherry, J. Amer. Chem. Soc., 127, 17572-17573 (2005).

“Structural and Chiroptical Properties of the Two Coordination Isomers of YbDOTA-type Complexes”, L Di Bari, G Pescitelli, AD Sherry & M Woods, Inorg. Chem. 44, 8391-8398 (2005).

“Towards the Rational Design of Contrast Agents: A Practical Approach to the Synthesis of Gadolinium Complexes that Exhibit Optimal Water Exchange”, M Woods, M Botta, J Wang & AD Sherry, J. Chem Soc., Dalton Trans., 3829-3837 (2005).

“High Resolution pHe Imaging of Rat Glioma using pH-dependent relaxivity”, ML Garcia-Martin, GV Martinez, N Raghunand, AD Sherry, S Zhang & RJ Gillies, Magn. Reson. Med., 55, 309-315 (2006).

“Effects of Insulin and Cytosolic Redox State on Glucose Production Pathways in the Isolated Perfused Mouse Liver by Integrated 2H and 13C NMR”, N Hausler, J Browning, M Merritt, C Storey, A Milde, FMH Jeffrey, AD Sherry, CR Malloy & SC Burgess, Biochem. J., 394, 465-473 (2006).

“Catalytic effects of apoferritin interior surface residues on water exchange in lanthanide complexes”, O Vasalatiy, P Zhao, S Zhang, S Aime & AD Sherry, Contrast Media & Mol Imaging, 1, 1-5 (2006).

“Diminished Hepatic Gluconeogenesis via Defects in TCA Cycle Flux in PPARγ Coactivator-1α (PGC-1α)-Deficient Mice”, SC Burgess, TC Leone, AR Wende, MA Croce, Z Chen, AD Sherry, CR Malloy & BN Finck, Diabetes, J. Biol. Chem. 281, 19000-19008 (2006).

“Europium(III) Macrocyclic Complexes with Alcohol Pendant Groups as Chemical Exchange Saturation Transfer (CEST) Agents” M Woods, DE Woessner, P Zhao, A Pasha, M-Y Yang, C-H Huang, O Vasalitiy, JR Morrow, AD Sherry” J. Amer. Chem. Soc. 128, 10155-10162 (2006).

“Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging”, M Woods, DE Woessner & AD Sherry, Chem Soc Rev, 35, 500-511 (2006).

“Storage and Oxidation of Long Chain Fatty Acids in the C57/BL6 Mouse Heart as Measured by NMR Spectroscopy”, KA Stowe, SC Burgess, M Merritt, AD Sherry, CR Malloy, FEBS Lett., 580, 4282-4287 (2006).

“Compensatory Responses to Pyruvate Carboxylase Suppression in Islet Beta-cells: Preservation of Glucose-Stimulated Insulin Secretion”, MV Jensen, JW Joseph, O Ilkaveva, SC Burgess, D Lu, S Ronnebaum, M Odegaard, TC Becker, AD Sherry & CB Newgard, J. Biol. Chem. 281, 22342-22351 (2006).

“Equilibrium and Formation/Dissociation Kinetics of some Lanthanide(III)-PCTA complexes”, G Tircsó, Z Kovács, & A D Sherry, Inorg. Chem., 45, 9269-9280 (2006).

“Sensitivity Enhancement of Multidimensional NMR experiments by Paramagnetic Relaxation Effect”, S Cai, C Seu, Z Kovacs, AD Sherry & Y Chen, J. Am. Chem. Soc., 128, 13474-13478 (2006).

“Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems”, N Nasongkla, E Bey, J Ren, H Ai, C Khemtong, JG Setti, SF Chin, AD Sherry, DA Boothman, J Gao, Nano Letters, 6, 2427-2430 (2006).

“PARACEST agents for Molecular Imaging” in Molecular & Cellular MR Imaging, Edited by J Bulte & M Modo, AD Sherry & M Woods, CRC Press, Chapter 6, pp. 101-122 (2007).

“A Bridge to Coordination Isomer Selection in Lanthanide(III) DOTA-tetraamide Complexes”, J Vipond, M Woods, P Zhao, G Tircso, Jimmy Ren, GE Kiefer, Zoltan Kovacs & AD Sherry, Inorg. Chem., 46, 2584-2595 (2007).

“Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Prediabetic and Diabetic Zucker (fa/fa) Rats”, ES Jin, B-H Park, AD Sherry & CR Malloy, Diabetes, 56, 777-785 (2007).

“MRI Detection of Glycogen In Vivo Using Chemical Exchange Saturation Transfer Imaging (glycoCEST)”, PCM van Zijl, CK Jones, J Ren, CR Malloy & AD Sherry, Proc. Natl. Acad. Sci., USA, 104, 4359-4364 (2007).

“Cytosolic phosphoenolpyruvate carboxykinase does not solely control the control the rate of hepatic gluconeogenesis in the intact mouse liver”, SC Burgess, T He, Z Yan, J Lindner, AD Sherry, CR Malloy, JD Browning & MA Magnuson, Cell Metabolism, 5, 313-320 (2007).

“Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications”, C Adair, M Woods, P Zhao, A Pasha, PM Winter, GM Lanza, P Athey, AD Sherry, GE Kiefer, Contrast Media & Molecular Imaging 2, 55-58 (2007).

“Potentiometric and Relaxometric Properties of Gadolinium-based MRI Contrast Agent for Sensing Tissue pH”, FK Kálmán, M Woods, P Jurek, M Spiller, P Caravan, G Tircsó, R Király, E Brücher & AD Sherry, Inorg. Chem., 46, 5260-5270 (2007).

“MRI detection of Paramagnetic Chemical Exchange Effects in mice kidneys in vivo”, E. Vinogradov, H He, A Lubag, JA Balschi, AD Sherry & RE Lenkinski, Magn Reson Med., 58, 650-655 (2007).

“Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion”, JW Joseph, ML Odegaard, SM Ronnebaum, SC Burgess, J Muehlbauer, AD Sherry & CB Newgard, J Biol Chem., 282, 31592-31600 (2007).

“Synthesis and characterization of DOTA-(amide)4 derivatives: equilibrium and kinetic behavior of their lanthanide(III) complexes”, A Pasha, G Tircso, ET Benyo, E Brucher & AD Sherry, Eur. J. Inorg. Chem., 4340-4349 (2007).

“Albumin-binding PARACEST Agents”, MM Ali, M Woods, E Suh, G Tircsó, V Kodibagkar & AD Sherry, J. Biol. Inorg. Chem., 12, 855-865 (2007).

“Dipolar cross-relaxation modulates signal amplitudes in the 1H NMR spectrum of hyperpolarized [13C]formate”, ME Merritt, C Harrison, W Mander, CR Malloy & AD Sherry, J. Magn. Reson., 189, 280-285 (2007).

“Hyperpolarized 13C Allows a Direct Measure of Flux through a Single Enzyme-Catalyzed Step by NMR”, M Merritt, C Harrison, C Storey, FMH Jeffrey, AD Sherry & CR Malloy, Proc. Natl. Acad. Sci., USA, 104, 19773-19777 (2007).

“Hyperpolarized 89Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance”, ME Merritt, C Harrison, Z Kovacs, P Kshirsagar, CR Malloy & AD Sherry, J. Amer. Chem. Soc., 129, 12942-12943 (2007).

“Modulation of Water Exchange in Europium(III) DOTA-tetraamide Complexes via Electronic Substituent Effects”, SJ Ratnakar, Mark Woods, AJM Lubag, Z Kovács & AD Sherry, J. Amer. Chem. Soc., 130, 6-7 (2008).