The Sherry Lab

Professor of Chemistry

Biographical Sketch

Cecil and Ida Green Distinguished Chair in Systems Bioscience
Professor of Chemistry
Director, Advanced Imaging Research Center, UT-Southwestern
Professor of Radiology, UT-Southwestern

Education

B. Sc., Chemistry, Wisconsin State University, LaCrosse, 1967
Ph. D., Inorganic Chemistry, Kansas State University, 1971

Fields of Research Specialization

Biomedical magnetic resonance techniques, applications of 13C & 2H NMR to study intermediary metabolism, lanthanide based MRI contrast agents, biologically responsive imaging agents and lanthanide-macrocyclic complexes.

Employment History

1971-1972 National Institutes of Health Postdoctoral Fellow, New Mexico State University
1972-1976 Assistant Professor, University of Texas at Dallas
1975-1980 Visiting Staff Member, Los Alamos Scientific Laboratories
1976-1982 Associate Professor, University of Texas at Dallas
1979-1990 Head, Programs in Chemistry, University of Texas at Dallas
1982-pres. Professor of Chemistry, University of Texas at Dallas
1983-1984 NIH Senior Fellow, University of Texas Southwestern Medical Center, Dallas
1991-pres. Professor of Radiology, University of Texas Southwestern Medical Center, Dallas
2005-pres. Director, Advanced Imaging Research Center, UT-Southwestern Medical Center

Awards, Fellowships and Current Memberships

NSF Research Trainee, 1970-1971, Kansas State University
NIH Postdoctoral Fellow, 1971-1972, New Mexico State University
AWU-AEC Summer Faculty Fellowship, 1975, Los Alamos Scientific Lab.
NIH Senior Fellow, 1983-1984, University of Texas Southwestern Medical Center, Dallas
W.T. Doherty Award, 1990, DFW Section of the American Chemical Society
UT-Dallas Chancellor's Council Outstanding Teaching Award, 1994
American Chemical Society, Phi Kappa Phi, Phi Lambda Upsilon
Biophysical Chemistry (BBCB) Study Section Member, 1999-2003
Scientific Founder, Macrocyclics, Inc.

Recent Publication Highlights (from 330)

“Chemistry for DOTA peptide labeling at phenylalanine residues: On the road to preparing peptide ligand tagged libraries”, LM De León-Rodríguez, Z Kovacs & AD Sherry, Lett Org Chem, 2, 160-164 (2005).
 
“A numerical solution of the Bloch equations provides insights into the optimal design of PARACEST agents for MRI”, DE Woessner, S Zhang, ME Merritt & AD Sherry, Magn. Reson. Med., 53, 790-799 (2005).
 
“Modulation of the Lifetime of Water Bound to Lanthanide Metal Ions in Complexes with Ligands Derived from 1,4,7,10-Tetraazacyclododecane Tetraacetate (DOTA)”, S Zhang, X Jiang & AD Sherry, Helv. Chim. Acta, 88, 923-935 (2005).
 
“Metabolic Networks in the Liver by 2H and 13C NMR” In Metabolomics by In Vivo NMR, Edited by RG Shulman & DA Rothman, John Wiley & Sons, Ltd., West Sussex, England, Chapter 12, pp 159-174 (2005).
 
“Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart”, X Yu, SC Burgess, H Ge, KK Wong, RH Nassem, DJ Garry, AD Sherry, CR Malloy, JP Berger, C Li, Proc Natl Acad Sci USA, 102, 1767-1772 (2005).
 
“Effect of Murine Strain on Metabolic Pathways of Glucose Production after Brief or Prolonged Fasting” SC Burgess, FMH Jeffrey, C Storey, A Milde, N Hausler, ME Merritt, H Mulder, C Holm, AD Sherry & CR Malloy, Amer. J. Physiol., 289, E53-E61 (2005).
 
“Differing Mechanisms of Hepatic Glucose Overproduction in Triiodothyronine-Treated Rats versus Zucker Diabetic Fatty Rats by NMR Analysis of Plasma Glucose” ES Jin, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Amer. J. Physiol., 288, E654-E662 (2005).
 
“Comparison of [3,4-13C2]Glucose to [6,6-2H2]Glucose as a Tracer for Glucose Turnover by Nuclear Magnetic Resonance” ES Jin, JG Jones, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Magn. Reson. Med., 53, 1479-1483 (2005).
 
“On Resonance Low B1 Pulses for Imaging of the Effects of PARACEST Agents”, E Vinogradov, S Zhang, A Lubag, JA Balschi, AD Sherry and RE Lenkinski, J. Magn. Reson., 176, 54-63 (2005).
 
“Water Exchange is the Key Parameter in the Design of Next-Generation MRI Agents”, AD Sherry, S Zhang & M Woods, ACS Symposium Series 903 (2005).
 
“Selective Sensing of Zn2+ with a Novel PARACEST Agent”, R Trokowski, J Ren, FK Kalman & AD Sherry, Angew. Chem. Int. Ed., 44, 6920-6923 (2005).
 
“MRI Thermometry Based on PARACEST Agents”, S Zhang, CR Malloy & AD Sherry, J. Amer. Chem. Soc., 127, 17572-17573 (2005).
 
 “Structural and Chiroptical Properties of the Two Coordination Isomers of YbDOTA-type Complexes”, L Di Bari, G Pescitelli, AD Sherry & M Woods, Inorg. Chem. 44, 8391-8398 (2005).
 
“Towards the Rational Design of Contrast Agents:  A Practical Approach to the Synthesis of Gadolinium Complexes that Exhibit Optimal Water Exchange”, M Woods, M Botta, J Wang & AD Sherry, J. Chem Soc., Dalton Trans., 3829-3837 (2005).
 
 “High Resolution pHe Imaging of Rat Glioma using pH-dependent relaxivity”, ML Garcia-Martin, GV Martinez, N Raghunand, AD Sherry, S Zhang &  RJ Gillies, Magn. Reson. Med., 55, 309-315 (2006).
 
 “Effects of Insulin and Cytosolic Redox State on Glucose Production Pathways in the Isolated Perfused Mouse Liver by Integrated 2H and 13C NMR”, N Hausler, J Browning, M Merritt, C Storey, A Milde, FMH Jeffrey, AD Sherry, CR Malloy & SC Burgess, Biochem. J., 394, 465-473 (2006).
 
“A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase and NADPH Production Regulate Glucose-Stimulated Insulin Secretion” S Ronnebaum, O Ilkayeva,  SC Burgess, D Lu, JW Joseph, RD Stevens, TC Becker, AD Sherry, CB Newgard, & MV Jensen, J. Biol. Chem., 281, 30593-30602 (2006).
 
“Catalytic effects of apoferritin interior surface residues on water exchange in lanthanide complexes”, O Vasalatiy, P Zhao, S Zhang, S Aime & AD Sherry, Contrast Media & Mol Imaging, 1, 1-5 (2006).
 
“Diminished Hepatic Gluconeogenesis via Defects in TCA Cycle Flux in PPARγ Coactivator-1α (PGC-1α)-Deficient Mice”, SC Burgess, TC Leone, AR Wende, MA Croce, Z Chen, AD Sherry, CR Malloy & BN Finck, Diabetes, J. Biol. Chem. 281,  19000-19008 (2006).
 
“Europium(III) Macrocyclic Complexes with Alcohol Pendant Groups as Chemical Exchange Saturation Transfer (CEST) Agents” M Woods, DE Woessner, P Zhao, A Pasha, M-Y Yang, C-H Huang, O Vasalitiy, JR Morrow, AD Sherry” J. Amer. Chem. Soc. 128, 10155-10162 (2006).
 
 “Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging”, M Woods, DE Woessner & AD Sherry, Chem Soc Rev, 35, 500-511 (2006).
 
 “Storage and Oxidation of Long Chain Fatty Acids in the C57/BL6 Mouse Heart as Measured by NMR Spectroscopy”, KA Stowe, SC Burgess, M Merritt, AD Sherry, CR Malloy, FEBS Lett., 580, 4282-4287 (2006).
 
“Compensatory Responses to Pyruvate Carboxylase Suppression in Islet b-cells: Preservation of Glucose-Stimulated Insulin Secretion”, MV Jensen, JW Joseph, O Ilkaveva, SC Burgess, D Lu, S Ronnebaum, M Odegaard, TC Becker, AD Sherry & CB Newgard, J. Biol. Chem. 281, 22342-22351 (2006).
 
“Equilibrium and Formation/Dissociation Kinetics of some Lanthanide(III)-PCTA complexes”, G Tircsó, Z Kovács, & A D Sherry, Inorg. Chem., 45, 9269-9280 (2006).
 
“Sensitivity Enhancement of Multidimensional NMR experiments by Paramagnetic Relaxation Effect”, S Cai, C Seu, Z Kovacs, AD Sherry & Y Chen, J. Am. Chem. Soc., 128, 13474-13478 (2006).  
“Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems”, N Nasongkla, E Bey, J Ren, H Ai, C Khemtong, JG Setti, SF Chin, AD Sherry, DA Boothman, J Gao, Nano Letters, 6, 2427-2430 (2006).

“A Bridge to Coordination Isomer Selection in Lanthanide(III) DOTA-tetraamide Complexes”, J Vipond, M Woods, P Zhao, G Tircso, Jimmy Ren, GE Kiefer, Zoltan Kovacs & AD Sherry, Inorg. Chem., 46, 2584-2595 (2007).
 
“PARACEST agents for Molecular Imaging” in Molecular & Cellular MR Imaging, Edited by J Bulte & M Modo, AD Sherry & M Woods, CRC Press, Chapter 6, pp. 101-122 (2007).
 
“Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Prediabetic and Diabetic Zucker (fa/fa) Rats”, ES Jin, B-H Park, AD Sherry & CR Malloy, Diabetes, 56, 777-785 (2007).
 
“MRI Detection of Glycogen In Vivo Using Chemical Exchange Saturation Transfer Imaging (glycoCEST)”, PCM van Zijl, CK Jones, J Ren, CR Malloy & AD Sherry, Proc. Natl. Acad. Sci., USA, 104, 4359-4364 (2007).
 
“Cytosolic phosphoenolpyruvate carboxykinase does not solely control the control the rate of hepatic gluconeogenesis in the intact mouse liver”, SC Burgess, T He, Z Yan, J Lindner, AD Sherry, CR Malloy, JD Browning & MA Magnuson, Cell Metabolism, 5, 313-320 (2007).
 
“Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications”, C Adair, M Woods, P Zhao, A Pasha, PM Winter, GM Lanza, P Athey, AD Sherry, GE Kiefer, Contrast Media & Molecular Imaging  2, 55-58 (2007).
 
“Potentiometric and Relaxometric Properties of Gadolinium-based MRI Contrast Agent for Sensing Tissue pH”, FK Kálmán, M Woods, P Jurek, M Spiller, P Caravan, G Tircsó, R Király, E Brücher & AD Sherry, Inorg. Chem., 46, 5260-5270 (2007).
 
“MRI detection of Paramagnetic Chemical Exchange Effects in mice kidneys in vivo”, E. Vinogradov, H He, A Lubag, JA Balschi, AD Sherry & RE Lenkinski, Magn Reson Med., 58, 650-655 (2007).  
 
“Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion”, JW Joseph, ML Odegaard, SM Ronnebaum, SC Burgess, J Muehlbauer, AD Sherry & CB Newgard, J Biol Chem., 282, 31592-31600 (2007).
 
“Synthesis and characterization of DOTA-(amide)4 derivatives: equilibrium and kinetic behavior of their lanthanide(III) complexes”, A Pasha, G Tircso, ET Benyo, E Brucher & AD Sherry, Eur. J. Inorg. Chem., 4340-4349 (2007).
 
“Albumin-binding PARACEST Agents”, MM Ali,  M Woods, EH Suh, Z Kovacs, G Tircsó, P Zhao, V Kodibagkar & AD Sherry, J. Biol. Inorg. Chem., 12, 855-865 (2007).
 
“Dipolar cross-relaxation modulates signal amplitudes in the 1H NMR spectrum of hyperpolarized [13C]formate”, ME Merritt, C Harrison, W Mander, CR Malloy & AD Sherry, J. Magn. Reson., 189, 280-285 (2007).
 
“Hyperpolarized 13C Allows a Direct Measure of Flux through a Single Enzyme-Catalyzed Step by NMR”, ME Merritt, C Harrison, C Storey, FMH Jeffrey, AD Sherry & CR Malloy, Proc. Natl. Acad. Sci., USA, 104, 19773-19777 (2007).
 
“Hyperpolarized 89Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance”, ME Merritt, C Harrison, Z Kovacs, P Kshirsagar, CR Malloy & AD Sherry, J. Amer. Chem. Soc., 129, 12942-12943 (2007).
 
“Modulation of Water Exchange in Europium(III) DOTA-tetraamide Complexes via Electronic Substituent Effects”, SJ Ratnakar, M Woods, AJM Lubag, Z Kovács & AD Sherry, J. Amer. Chem. Soc., 130, 6-7 (2008).
 
“Towards the Rational Design of MRI Contrast Agents: Electron spin Relaxation is Largely Unaffected by the Coordination Geometry of Gadolinium(III) DOTA-type Complexes”, A Borel, JF Bean, RB Clarkson, L Helm, L Moriggi, AD Sherry & Mark Woods, Chem. Eur. J., 14, 2658-2667 (2008).
 
“Labeling of Adenovirus Particles with PARACEST Agents”, O Vasalatiy, R Gerard, P Zhao, X Sun & AD Sherry, Bioconj. Chem., 19, 598-606 (2008).
 
“The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain”, K Hanaoka, AJM Lubag, A Castillo-Muzquiz, T Kodadek & AD Sherry, J. Magn. Reson. Imaging, 26, 608-617 (2008).
 
“Advances in molecular imaging of pancreatic beta cells”, M Lin, A Lubag, MJ McGuire, SY Seliounine, EN Tsyganov, PP Antich, AD Sherry, KC Brown & X Sun, Frontiers in Bioscience, 13, 4558-4575 (2008).
 
“Nephrogenic Systemic Fibrosis:  A Chemical and Rational Perspective”, NM Rofsky, AD Sherry and RE Lenkinski, Radiology, 247, 608-612 (2008).
 
“Chronic Suppression of Acetyl CoA Carboxylase 1 in b-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism”, SM Ronnebaum, JW Joseph, O Ilkayeva, SC Burgess, D Lu, TC Becker, AD Sherry & CB Newgard, J. Biol. Chem., 283, 14248-14256 (2008).
 
"Potentiometric, kinetic and NMR studies of 1,7-bis(acetic acid)-4,10-bis(methylene phosphonic acid)-1,4,7,10-tetraazacyclododecane (DO2A2P) and its complexes with Ca2+, Cu2+, Zn2+ and lanthanide(III) ions", FK Kalman, Z Baranyai, I Toth, I Bányai, R Király, E Brucher, S Aime, X Sun, AD Sherry, & Z Kovács, Inorg. Chem., 47, 3851-3862 (2008).
 
“Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes”,  JM Zhao, Y Har-el, MT McMahon, J Zhou, AD Sherry, G Sgouros, JW Bulte, PCM van Zijl,   J. Amer. Chem. Soc., 130, 5178-5184 (2008).
 
“Synthesis and Relaxometric Studies of a Dendrimer-Based pH-Responsive MRI Contrast Agent”, MM Ali, M Woods, P Caravan, ACL Opina, M Spiller, JC Fettinger & AD Sherry, Chem. Eur. J., 14, 7250-7258 (2008).
 
“Composition of Adipose Tissue and Marrow Fat in Humans by 1H NMR at 7T”, J Ren, I Dimitrov, AD Sherry  & CR Malloy, J. Lipid Res, 49, 2055-2062 (2008).
 
“Imaging the Tissue Distribution of Glucose in Liver using a PARACEST Sensor”, J Ren, S Zhang,  R Trokowski, C Storey, A Milde, CR Malloy & AD Sherry, Magn. Reson. Med., 60, 1047-1055 (2008).
 
“Chemical Exchange Saturation Transfer Contrast Agents for Magnetic Resonance Imaging”. AD Sherry & M Woods, Ann. Rev. Biomed. Eng., 10, 391-411 (2008).

“The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives”, P Caravan, CFGC Geraldes, MT Greenfield, GE Kiefer, M Lin, K McMillan, MIM Prata, AC Santos, AD Sherry, X Sun, J Wang, M Woods, S Zhang & P Zhao, Invest. Radiol., 43, 861-870 (2008).

“Inhibition of Carbohydrate Oxidation during the First Minute of Reperfusion after Brief Ischemia: NMR Detection of Hyperpolarized 13CO2 and H13CO3-”, ME Merritt, C Harrison, C Storey, AD Sherry & CR Malloy, Magn. Reson. Med., 60, 1029-1036 (2008).
 
“Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets”, SM Ronnebaum, MV Jensen, HE Hohmeier, SC Burgess, YP Zhou, S Qian, D Macneil, A Howard, N Thronberry, O Ilkayeva, D Lu, AD Sherry & CB Newgard,J Biol Chem., 283, 28909-28917 (2008).
 
“Polymeric PARACEST Agents for Enhancing MRI Contrast Sensitivity”, Y Wu, Y Zhou, O Ouari, M Woods, P Zhao, TC Soesbe, GE Kiefer & AD Sherry, J. Amer. Chem. Soc., 130, 13854-13855 (2008).
 
“Metabolic Cycling in Control of Glucose-stimulated Insulin Secretion”, MV Jensen, JW Joseph, SM Ronnebaum, SC Burgess, AD Sherry & CB Newgard, Am. J. Physiol., 295, E1287-E1297 (2008).
 
“Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups”, A Pasha, M Lin, G Tircso, M Woods, GE Kiefer, AD Sherry & X Sun, J. Biol. Inorg. Chem., 14, 421-438 (2009).

“Orientation of Lipid Strands in the Extracellular Compartment of Muscle: Effect on Quantitation of Intramyocellular Lipids” A Khuu, J Ren, I Dimitrov, DE Woessner, J Murdoch, AD Sherry & CR Malloy, Magn. Reson. Med., 61, 16-21 (2009).
 
“In vivo Off-Resonance Saturation Magnetic Resonance Imaging of avb3-Targeted Superparamagnetic Nanoparticles”, C Khemtong, CW Kessinger, J Ren, EA Bey, S-G Yang, JS Guthi, DA Boothman, AD Sherry & J Gao, Cancer Res., 69, 1651-1658 (2009).
 
“Evidence for reverse flux through pyruvate kinase in skeletal muscle”, ES Jin, AD Sherry & CR Malloy, Amer. J. Physiol., 296, E748-E757 (2009).
 
“Comprehensive metabolic analysis for understanding of disease mechanisms” CB Newgard, RD Stevens, BR Wenner, SC Burgess, O Ilkayeva, MJ Muehlbauer, AD Sherry & JR Bain, Genomic and Personalized Medicine, 1, 180-192 (2009).
 
“(S)-5-(p-nitrobenzyl)-PCTA, a Promising Bifunctional Ligand with Advantageous Metal Ion Complexation Kinetics”, G Tircso, E Tircsone-Benyo, EH Suh, P Jurek, GE Kiefer, AD Sherry & Z Kovacs, Bioconjugate Chemistry, 20, 565-575 (2009).  
 
“A New Gadolinium-based MRI Zinc Sensor”, AC Esqueda, JA López, G Andreu-de-Riquer, JC Alvarado-Monzón, J Ratnakar, AJM Lubag, AD Sherry & LM De León-Rodríguez, J. Amer. Chem. Soc., 131, 11387-11391 (2009).

“Modulation of Water Exchange in EuDOTA-tetraamide Complexes: Considerations for in vivo Imaging of PARACEST Agents”, T Mani, G Tircsó, O Togao, P Zhao, T Soesbe, M Takahashi & AD Sherry, Contrast Media & Mol Imaging, 4, 183-191 (2009).
 
“Responsive MRI agents for sensing metabolism in vivo” LM De Leon-Rodriguez, AJM Lubag, CR Malloy, GV Martinez, RJ Gillies & AD Sherry, Accts. Chem. Res., 42, 948-957 (2009).
 
“A primer on gadolinium chemistry”, AD Sherry, P Caravan & RE Lenkinski, J. Magn. Reson. Imag., 30, 1240-1248 (2009).
 
“NMR Characterization of Lanthanide(III) Complexes of Tetraazatetrakisphosphinato and tetraazatetrakisphophonato Ligands”, GA Pereira, L Ball, AD Sherry, JA Peters and CFGC Geraldes, Helv. Chim. Acta, 92, 2532-2551 (2009).
 
“The Effect of the Regiochemistry of Butyl Amide Substituents on the Solution-State Structures of Lanthanide(III) DOTA-tetraamide complexes”, T Mani, M Woods, P Zhao, G Tircsó & AD Sherry, Inorg. Chem., 48, 10338-10345 (2009).

“Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents”,  SE Plush, M Woods, Y Zhou, SB Kadali & MS Wong, J. Amer. Chem. Soc., 131, 15918-15923 (2009).

“Lanthanide(III) complexes of tris(amide)-PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents”, FA Rojas-Quijano, ET Benyó, G Tircsó, FK Kálmán, Z Baranyai, S Aime, AD Sherry & Z Kovács, Chem. Eur. J., 15, 13188-13200 (2009).
 
“Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands”, S Viswanathan, SJ Ratnakar, KN Green, Z Kovacs, LM De León & AD Sherry, Angew. Chem. Int. Ed., 48, 9330-9333 (2009).

“A Multislice Gradient Echo Pulse Sequence for CEST Imaging”, WT Dixon, I Hancu, SJ Ratnaker, AD Sherry, RE Lenkinski & DC Alsop, Magn. Reson. Med., 63, 253–256 (2010).

“Hyperpolarized 89Y Complexes as pH Sensitive NMR Probes”, AK Jindal, ME Merritt, EH Suh, CR Malloy, AD Sherry & Z Kovacs, J. Amer. Chem. Soc., 132, 1784-1785 (2010).

“A Concentration-Independent Method to Measure Exchange Rates in PARACEST Agents”, WT Dixon, J Ren, J Ratnakar, E Vinogradov, RE Lenkinski & AD Sherry, Magn. Reson. Med., 63, 625-632 (2010).