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A carbon-13 NMR isotopomer analysis shows that hearts from hypertensive animals (bottom) oxidize less fat and more carbohydrate than hearts from control animals (top).

¹³C NMR Analysis of Metabolic Pathways

“Analytical Solutions for 13C Isotopomer Analysis of Complex Metabolic Conditions: Substrate Oxidation, Multiple Pyruvate Cycles and Gluconeogenesis” AD Sherry, FMH Jeffrey & CR Malloy, Metabolic Engineering, 6, 12-24 (2004).

“Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative”, ES Jin, JG Jones, M Merritt, SC Burgess, CR Malloy & AD Sherry, Analy. Biochem., 327, 149-155 (2004).

“Compartmentation of Glycolysis and Glycogenolysis in the Perfused Rat Heart”, RA Carvalho, N Anousis, P Zhao, CR Malloy & AD Sherry, NMR Biomed., 17, 51-59 (2004).

“Glucose Production Pathways in Patients with HIV-Associated Lipodystrophy by 2H and 13C NMR of Plasma and Urine”, BC Weis, D Margolis, SC Burgess, ME Merritt, H Wise, AD Sherry & CR Malloy, Magn. Reson. Med., 51, 649-654 (2004).

“A 13C Isotopomer Kinetic Analysis of Cardiac Metabolism: Influence of Altered Cytosolic Redox and Extracellular [Ca2+]”, RA Carvalho, TB Rodrigues, P Zhao, FMH Jeffrey, CR Malloy & AD Sherry, Amer. J. Physiol., 287, H889-H895 (2004).

“Concurrent 31P NMR and Fiber-optic Based Oxygen Consumption Measurements in Perfused Rat Hearts”, P. Zhao, Y. Zhao, AD Sherry & P. Pantano, Methods Enzymol., Methods Enzymol., 391, 735-746 (2004).

“Biochemical Mechanism of Lipid-Induced Impairment of Glucose-Stimulated Insulin Secretion and Reversal with a Malate Analogue”, A Boucher, D Lu, SC Burgess, S Telemaque-Potts, MV Jensen, H Mulder, M-Y Wang, RH Unger, AD Sherry & CB Newgard, J. Biol. Chem., 279, 27263-27271 (2004).

“Understanding of Basic Mechanisms of -Cell Function and Survival: Prelude to New Diabetes Therapies”, CB Newgard, HE Hohmeier, D Lu, MV Jensen, VV Tran, G Chen, SC Burgess, & AD Sherry, Cell Biochem. & Biophysics, 40, 159-168 (2004).

“Impaired TCA cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase”, SC Burgess, N Hausler, M Merritt, C Storey, A Milde, S Koshy, J Lindner, MA Magnuson, CR Malloy & AD Sherry, J. Biol Chem., 279, 48941-48949 (2004).

“Metabolic Networks in the Liver by 2H and 13C NMR” In Metabolomics by In Vivo NMR, Edited by RG Shulman & DA Rothman, John Wiley & Sons, Ltd., West Sussex, England, Chapter 12, pp 159-174 (2005).

“Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart”, X Yu, SC Burgess, H Ge, KK Wong, RH Nassem, DJ Garry, AD Sherry, CR Malloy, JP Berger, C Li, Proc Natl Acad Sci USA, 102, 1767-1772 (2005).

“Effect of Murine Strain on Metabolic Pathways of Glucose Production after Brief or Prolonged Fasting” SC Burgess, FMH Jeffrey, C Storey, A Milde, N Hausler, ME Merritt, H Mulder, C Holm, AD Sherry & CR Malloy, Amer. J. Physiol., 289, E53-E61 (2005).

“Differing Mechanisms of Hepatic Glucose Overproduction in Triiodothyronine-Treated Rats versus Zucker Diabetic Fatty Rats by NMR Analysis of Plasma Glucose” ES Jin, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Amer. J. Physiol., 288, E654-E662 (2005).

“Comparison of [3,4-13C2]Glucose to [6,6-2H2]Glucose as a Tracer for Glucose Turnover by Nuclear Magnetic Resonance” ES Jin, JG Jones, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Magn. Reson. Med., 53, 1479-1483 (2005).

“Effects of Insulin and Cytosolic Redox State on Glucose Production Pathways in the Isolated Perfused Mouse Liver by Integrated 2H and 13C NMR”, N Hausler, J Browning, M Merritt, C Storey, A Milde, FMH Jeffrey, AD Sherry, CR Malloy & SC Burgess, Biochem. J., 394, 465-473 (2006).

“Diminished Hepatic Gluconeogenesis via Defects in TCA Cycle Flux in PPARγ Coactivator-1α (PGC-1α)-Deficient Mice”, SC Burgess, TC Leone, AR Wende, MA Croce, Z Chen, AD Sherry, CR Malloy & BN Finck, Diabetes, J. Biol. Chem. 281, 19000-19008 (2006).

“Storage and Oxidation of Long Chain Fatty Acids in the C57/BL6 Mouse Heart as Measured by NMR Spectroscopy”, KA Stowe, SC Burgess, M Merritt, AD Sherry, CR Malloy, FEBS Lett., 580, 4282-4287 (2006).

“Compensatory Responses to Pyruvate Carboxylase Suppression in Islet -cells: Preservation of Glucose-Stimulated Insulin Secretion”, MV Jensen, JW Joseph, O Ilkaveva, SC Burgess, D Lu, S Ronnebaum, M Odegaard, TC Becker, AD Sherry & CB Newgard, J. Biol. Chem. 281, 22342-22351 (2006).

“A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase and NADPH Production Regulate Glucose-Stimulated Insulin Secretion” S Ronnebaum, O Ilkayeva,  SC Burgess, D Lu, JW Joseph, RD Stevens, TC Becker, AD Sherry, CB Newgard, & MV Jensen, J. Biol. Chem., 281, 30593-30602 (2006).
“Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Prediabetic and Diabetic Zucker (fa/fa) Rats”, ES Jin, B-H Park, AD Sherry & CR Malloy, Diabetes, 56, 777-785 (2007).
 “Cytosolic phosphoenolpyruvate carboxykinase does not solely control the control the rate of hepatic gluconeogenesis in the intact mouse liver”, SC Burgess, T He, Z Yan, J Lindner, AD Sherry, CR Malloy, JD Browning & MA Magnuson, Cell Metabolism, 5, 313-320 (2007).
“Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion”, JW Joseph, ML Odegaard, SM Ronnebaum, SC Burgess, J Muehlbauer, AD Sherry & CB Newgard, J Biol Chem., 282, 31592-31600 (2007).
“Chronic Suppression of Acetyl CoA Carboxylase 1 in b-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism”, SM Ronnebaum, JW Joseph, O Ilkayeva, SC Burgess, D Lu, TC Becker, AD Sherry & CB Newgard, J. Biol. Chem., 283, 14248-14256 (2008).
“Composition of Adipose Tissue and Marrow Fat in Humans by 1H NMR at 7T”, J Ren, I Dimitrov, AD Sherry  & CR Malloy, J. Lipid Res, 49, 2055-2062 (2008).
“Inhibition of Carbohydrate Oxidation during the First Minute of Reperfusion after Brief Ischemia: NMR Detection of Hyperpolarized 13CO2 and H13CO3-”, ME Merritt, C Harrison, C Storey, AD Sherry & CR Malloy, Magn. Reson. Med., 60, 1029-1036 (2008).
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets”, SM Ronnebaum, MV Jensen, HE Hohmeier, SC Burgess, YP Zhou, S Qian, D Macneil, A Howard, N Thronberry, O Ilkayeva, D Lu, AD Sherry & CB Newgard, J Biol Chem., 283, 28909-28917 (2008).
“Metabolic Cycling in Control of Glucose-stimulated Insulin Secretion”, MV Jensen, JW Joseph, SM Ronnebaum, SC Burgess, AD Sherry & CB Newgard, Am. J. Physiol., 295, E1287-E1297 (2008).
“Evidence for reverse flux through pyruvate kinase in skeletal muscle”, ES Jin, AD Sherry & CR Malloy, Amer. J. Physiol., 296, E748-E757 (2009).
“Comprehensive metabolic analysis for understanding of disease mechanisms” CB Newgard, RD Stevens, BR Wenner, SC Burgess, O Ilkayeva, MJ Muehlbauer, AD Sherry & JR Bain, Genomic and Personalized Medicine, 1, 180-192 (2009).
“Non-invasive 1H MRS detection of acetate metabolism in human skeletal muscle”, J. Ren, CR Malloy & AD Sherry, Proc. Natl. Acad. Sci., submitted.

“The Effect of 13C Enrichment in the Glassing Matrix on Dynamic nuclear Polarization of [1-13C]pyruvate”, L Lumata, Z Kovacs, CR Malloy, AD Sherry & ME Merritt, Phys Med. Biol.,  56: N85-N92 (2011).  

DNP by Thermal Mixing under Optimized Conditions Yields >60 000-fold Enhancement of (89)Y NMR Signal” LL Lumata, AK Jindal, ME Merritt, CR Malloy, AD Sherry & Z Kovacs, J. Amer. Chem. Soc., 133, 8673-8680 (2011).  

“BDPA:  An Efficient Polarizing Agent for Fast Dissolution Dynamic Nuclear Polarization NMR Spectroscopy” LL Lumata, SJ Ratnakar, AK Jindal, ME Merritt, A Comment, CR Malloy, AD Sherry & Z Kovacs, Chem. Eur. J., 17, 10825-10827 (2011). 

 “Could 13C MRI Assist Clinical Decision-Making for Patients with Heart Disease?” CR Malloy, ME Merritt & AD Sherry, NMR in Biomed., 24, 973-979 (2011).   

“Flux Through Hepatic Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase Detected by Hyperpolarized 13C Magnetic Resonance”,  ME Matthew , C Harrison, AD Sherry, CR Malloy SC Burgess, Proc. Natl. Acad. Sci. USA, 108, 19084-9 (2011).  
“Transfer of Hyperpolarization from Long T1 Storage Nuclei to Short T1 Neighbors Using FLOPSY-8”, K Moreno, C Harrison, AD Sherry, CR Malloy & ME Merritt, J. Magn. Reson., 213, 187-191 (2011).  

“13C NMR for Analysis of Metabolic Pathways”, CR Malloy, E Maher, I Marin-Valencia, B Mickey, RJ DeBerardinis & AD Sherry, in “Methodologies for Metabolomics”, edited by NW Lutz, JV Sweedler, RA Wevers, Cambridge University Press, 2013, pp. 415-445.

"Evidence for Transaldolase Activity in the Isolated Heart Supplied with [U-13C3]glycerol", ES Jin, AD Sherry & CR Malloy, J. Biol. Chem., 288, 2914-2922 (2013).

“Metabolism of Glycerol, Glucose and Lactate in the Citric Acid Cycle Prior to Incorporation into Hepatic Triglycerides”, E Jin, AD Sherry & CR Malloy, J. Biol. Chem., 288, 14488-14496 (2013).



Updated: February 12, 2014

©2006 The University of Texas at Dallas