
A carbon-13 NMR isotopomer analysis shows that hearts from hypertensive animals (bottom) oxidize less fat and more carbohydrate than hearts from control animals (top).
¹³C NMR Analysis of Metabolic Pathways
“Analytical Solutions for 13C Isotopomer Analysis of Complex Metabolic Conditions: Substrate Oxidation, Multiple Pyruvate Cycles and Gluconeogenesis” AD Sherry, FMH Jeffrey & CR Malloy, Metabolic Engineering, 6, 12-24 (2004).
“Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative”, ES Jin, JG Jones, M Merritt, SC Burgess, CR Malloy & AD Sherry, Analy. Biochem., 327, 149-155 (2004).
“Compartmentation of Glycolysis and Glycogenolysis in the Perfused Rat Heart”, RA Carvalho, N Anousis, P Zhao, CR Malloy & AD Sherry, NMR Biomed., 17, 51-59 (2004).
“Glucose Production Pathways in Patients with HIV-Associated Lipodystrophy by 2H and 13C NMR of Plasma and Urine”, BC Weis, D Margolis, SC Burgess, ME Merritt, H Wise, AD Sherry & CR Malloy, Magn. Reson. Med., 51, 649-654 (2004).
“A 13C Isotopomer Kinetic Analysis of Cardiac Metabolism: Influence of Altered Cytosolic Redox and Extracellular [Ca2+]”, RA Carvalho, TB Rodrigues, P Zhao, FMH Jeffrey, CR Malloy & AD Sherry, Amer. J. Physiol., 287, H889-H895 (2004).
“Concurrent 31P NMR and Fiber-optic Based Oxygen Consumption Measurements in Perfused Rat Hearts”, P. Zhao, Y. Zhao, AD Sherry & P. Pantano, Methods Enzymol., Methods Enzymol., 391, 735-746 (2004).
“Biochemical Mechanism of Lipid-Induced Impairment of Glucose-Stimulated Insulin Secretion and Reversal with a Malate Analogue”, A Boucher, D Lu, SC Burgess, S Telemaque-Potts, MV Jensen, H Mulder, M-Y Wang, RH Unger, AD Sherry & CB Newgard, J. Biol. Chem., 279, 27263-27271 (2004).
“Understanding of Basic Mechanisms of -Cell Function and Survival: Prelude to New Diabetes Therapies”, CB Newgard, HE Hohmeier, D Lu, MV Jensen, VV Tran, G Chen, SC Burgess, & AD Sherry, Cell Biochem. & Biophysics, 40, 159-168 (2004).
“Impaired TCA cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase”, SC Burgess, N Hausler, M Merritt, C Storey, A Milde, S Koshy, J Lindner, MA Magnuson, CR Malloy & AD Sherry, J. Biol Chem., 279, 48941-48949 (2004).
“Metabolic Networks in the Liver by 2H and 13C NMR” In Metabolomics by In Vivo NMR, Edited by RG Shulman & DA Rothman, John Wiley & Sons, Ltd., West Sussex, England, Chapter 12, pp 159-174 (2005).
“Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart”, X Yu, SC Burgess, H Ge, KK Wong, RH Nassem, DJ Garry, AD Sherry, CR Malloy, JP Berger, C Li, Proc Natl Acad Sci USA, 102, 1767-1772 (2005).
“Effect of Murine Strain on Metabolic Pathways of Glucose Production after Brief or Prolonged Fasting” SC Burgess, FMH Jeffrey, C Storey, A Milde, N Hausler, ME Merritt, H Mulder, C Holm, AD Sherry & CR Malloy, Amer. J. Physiol., 289, E53-E61 (2005).
“Differing Mechanisms of Hepatic Glucose Overproduction in Triiodothyronine-Treated Rats versus Zucker Diabetic Fatty Rats by NMR Analysis of Plasma Glucose” ES Jin, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Amer. J. Physiol., 288, E654-E662 (2005).
“Comparison of [3,4-13C2]Glucose to [6,6-2H2]Glucose as a Tracer for Glucose Turnover by Nuclear Magnetic Resonance” ES Jin, JG Jones, SC Burgess, ME Merritt, AD Sherry & CR Malloy, Magn. Reson. Med., 53, 1479-1483 (2005).
“Effects of Insulin and Cytosolic Redox State on Glucose Production Pathways in the Isolated Perfused Mouse Liver by Integrated 2H and 13C NMR”, N Hausler, J Browning, M Merritt, C Storey, A Milde, FMH Jeffrey, AD Sherry, CR Malloy & SC Burgess, Biochem. J., 394, 465-473 (2006).
“Diminished Hepatic Gluconeogenesis via Defects in TCA Cycle Flux in PPARγ Coactivator-1α (PGC-1α)-Deficient Mice”, SC Burgess, TC Leone, AR Wende, MA Croce, Z Chen, AD Sherry, CR Malloy & BN Finck, Diabetes, J. Biol. Chem. 281, 19000-19008 (2006).
“Storage and Oxidation of Long Chain Fatty Acids in the C57/BL6 Mouse Heart as Measured by NMR Spectroscopy”, KA Stowe, SC Burgess, M Merritt, AD Sherry, CR Malloy, FEBS Lett., 580, 4282-4287 (2006).
“Compensatory Responses to Pyruvate Carboxylase Suppression in Islet -cells: Preservation of Glucose-Stimulated Insulin Secretion”, MV Jensen, JW Joseph, O Ilkaveva, SC Burgess, D Lu, S Ronnebaum, M Odegaard, TC Becker, AD Sherry & CB Newgard, J. Biol. Chem. 281, 22342-22351 (2006).
“A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase and NADPH Production Regulate Glucose-Stimulated Insulin Secretion” S Ronnebaum, O Ilkayeva, SC Burgess, D Lu, JW Joseph, RD Stevens, TC Becker, AD Sherry, CB Newgard, & MV Jensen, J. Biol. Chem., in press.
Updated: December 11, 2006
