The Sherry Lab

R01 HL34557-19

Sherry (PI)

7/02-6/08

National Institutes of Health
Title: Intermediary Metabolism by 13C NMR
The major goals of this project are to develop novel 13C and 1H NMR techniques for examining intermediary metabolism in intact tissues and to apply such techniques to significant metabolic issues. Current studies involve the kinetics of 13C labeling of glutamate and other intermediates in isolated rat heart mitochondria and indirect 1H detection of 13C labeling in isolated perfuse mouse hearts.

AT-584

Sherry (PI)

6/05-5/08

The Robert A. Welch Foundation
Title: Lanthanide-based CEST Agents for Molecular Imaging
The major goals of this project are to synthesize a series of new DOTA-tetraamide ligands with variable steric strain, charges, and redox properties and examine the CEST properties of the resulting lanthanide complexes.

RO1 CA115531-01

Sherry (PI)

8/05 - 7/10

National Institutes of Health
Title: PARACEST Agents for Molecular Imaging of Cancer
The major goals of this project are to develop applications of paramagnetic chemical exchange saturation transfer imaging agents when bound to antibody surfaces and as small molecule sensors of hypoxia.

P01 DK058398-06

Newgard (PI)

9/06 – 8/11

National Institutes of Health (renewal – this application)
Title: Development of Novel Therapies for NIDDM
This is a renewal application for a project grant to continue studies of novel targets and imaging agents for imaging pancreatic beta cell function by MRI and PET. Dr. Christopher Newgard of Duke will become the PI of this program project grant involving several scientists at UTSW and at Duke.

P41 RR02584

Malloy (PI)

8/06-7/11

NIH Research Resources grant (renewal application)
Title: Metabolic Imaging Agents
The major goals of this project are to develop CEST imaging techniques for determining liver glycogen in animal models, apply glucose sensitive PARACEST agents to image the distribution of glucose in tissues in vivo, and to develop new agents for mapping of tissue pH by MRI.

U24 DK-59632

Malloy (PI)

7/06 – 6/11

National Institutes of Health
Title: Metabolic Phenotyping Center for Mouse Models of Diabetes
This project is one element of a national consortium involving three other centers with the shared goal of refining methods for metabolic studies in mice and in providing those methods to the research community.

RO1 EB004582-01

Lenkinski (PI)

5/06 – 4/09

National Institutes of Health
PARACEST Agents: Optimization for Human MR Imaging This is a bioengineering partnership application involving further development of the chemistry of PARACEST agents at UT Dallas, development of optimal pulse sequences for clinical scanners at GE Medical, and imaging of PARACEST agents in large animal models (pigs) at the Beth Israel Deaconess Medical Center in Boston, MA.