A. Dean Sherry , Ph.D.
Cecil and Ida Green Distinguished Chair in Systems Biology #1, Professor of Chemistry
Director, Advanced Imaging Research Center, U.T. Southwestern
MRI contrast agents; biomedical NMR
Research Group
Education
B.S., Wisconsin State University (1967): Chemistry
Ph.D., Kansas State University (1971): Physical/Inorganic Chemistry
NIH Postdoctoral Associate, New Mexico State University (1971–72)
Affiliations
Department of Radiology, U.T. Southwestern; Director
Advanced Imaging Research Center, U.T. Southwestern Medical Center, Dallas
Research Description
Our chemistry group at UT-Dallas is involved in the design of novel MR imaging agents that are responsive to physiology and metabolism.
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High relaxivity Gd3+-based agents that respond to binding events in vivo.
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Slow water exchange paramagnetic complexes that introduce MR contrast by a novel mechanism called chemical exchange saturation transfer (CEST). Paramagnetic CEST agents are now widely referred to a PARACEST agents.
Selected Publications
“Responsive MRI agents for sensing metabolism in vivo” LM De Leon-Rodriguez, AJM Lubag, CR Malloy, GV Martinez, RJ Gillies & AD Sherry, Accts. Chem. Res., 42, 948-957 (2009).
“Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents”, SE Plush, M Woods, Y Zhou, SB Kadali & MS Wong, J. Amer. Chem. Soc., 131, 15918-15923 (2009).
“Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands”, S Viswanathan, SJ Ratnakar, KN Green, Z Kovacs, LM De León & AD Sherry, Angew. Chem. Int. Ed., 48, 9330-9333 (2009).
- Updated: April 21, 2010
