About the AIRC Faculty Contacting the AIRC Mouse Imaging Core Facility Research Areas Opportunities
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About the AIRC

Academic Title Associate Professor
Primary
Appointment
Advanced Imaging Research Center
Secondary Appointment Radiology
School Southwestern Medical School
Degree Program Biomedical Engineering

Changho Choi PhD

Research Overview
One of the most exciting strengths of nuclear magnetic resonance spectroscopy (MRS) is its ability to measure biochemical concentrations in human body noninvasively. Despite the progress achieved during the past decades, precise and reliable measurements of several clinically-important, low abundance biochemicals are not straightforward due to the low signal intensity and the spectral overlap with large neighboring signals. The spins of many biochemicals are scalar coupled and as a result the signal intensity and spectral pattern vary with MRS sequence time. The selectivity and specificity of signals can be improved by means of spectral editing. Current researches focus on development/ optimization of proton spectral editing methods for detection of experimentally-challenging metabolites in the human and animal brain, including GABA, glutamate, glutamine, glycine, NAAG, 2-hydroxyglutarate, etc., at 3T, 7T and 9.4T.

Contact: changho.choi@utsouthwestern.edu

Research Interests

1H and 13C MRS Application of MRS to neurodegenerative and cancer diseases
RF pulse and RF coil design Density matrix simulation