About the AIRC Faculty Contacting the AIRC Mouse Imaging Core Facility Research Areas Opportunities
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About the AIRC

Academic Title Associate Professor
Advanced Imaging Research Center
Secondary Appointment Radiology

Frederick Mark Jeffrey D.Phil.

Research Overview
An important manifestation of the phenotype is the regulation of metabolism, from nucleotide synthesis to intermediary metabolism. Since regulation cumulates in modification of pathway fluxes, measurement of the latter is an important aspect of understanding metabolism. The more informative means of estimating flux involves the use of tracers, and the combination of the stable isotope 13C and 13C NMR spectroscopy has proved particularly valuable. Due to the complexity of intermediary metabolism and the data yield available from labeled substrates (particularly when more than one distinctively-labeled substrate is provided), mathematical modeling is required. Various models have been developed and provided as software for use in the scientific community. Some of the work carried out has also involved the complementary technique mass spectrometry (in particular, tandem mass spectrometry). These methods can be applied to a variety of experimental models, from isolated organelles to the whole body. The primary focus of the work has been metabolism of heart, liver and (most recently) brain.

Contact: mark.jeffrey@utsouthwestern.edu

Research Interests

1H and 13C NMR Spectroscopy Mathematical models of metabolism
In Vivo and Ex Vivo measurement of pathway fluxes Tandem mass spectrometry
NMR and non-invasive studies of intermediary metabolism