The measurement of comprehensive metabolic fluxes in vivo is important in understanding pathophysiology of a metabolic disease such as diabetes. It is challenging, but stable isotopes and NMR spectroscopy may allow us to study in vivo fluxes. My research interests are intermediary metabolism, obesity-associated type 2 diabetes, and glucose-fat metabolic interaction using stable isotopes and NMR as key research tools. I have used animal models in studying intermediary metabolism and diabetes, but recently started clinical research focusing on obesity-associated type 2 diabetes. The clinical study includes hyperinsulinemic euglycemic clamp technique and hepatic fat measurement using a 3T MR scanner in addition to multiple stable isotope administration and NMR spectroscopic analysis.
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|Insulin resistance & Type 2 diabetes||Glucose-fat metabolic interaction|