About the AIRC Faculty Contacting the AIRC Mouse Imaging Core Facility Research Areas Opportunities
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About the AIRC

Endowed Title Richard A. Lange Chair in Cardiology
Academic Title Professor
Primary
Appointment
Advanced Imaging Research Center
Secondary Appointment Internal Medicine - Cardiology
School Graduate School of Biomedical Sciences
Degree Program Biomedical Engineering
Molecular Biophysics
Radiological Sciences

Craig R. Malloy, MD

Research Overview
My major interest is the role of metabolism in disease. The details of individual reactions in the key biochemical pathways - glycolysis, the pentose phosphate pathway, the citric acid cycle and others - are well-understood. However the integration of these pathways in vivo is poorly understood because of the intricate interconnections and feedback loops in the control of metabolism. Classical radiotracer studies for investigation of metabolism have two major limitations. First, the information that can be obtained is very limited. Consequently, these methods are optimal for studies of individual enzymes and isolated organelles in a test tube where conditions are highly controlled. However these methods are inadequate for probing metabolism in intact animals and especially in humans with disease. The second limitation is that the use of radiotracers constrains many potential applications in clinical research.

Initially much of my work in collaboration with Dr. Dean Sherry was to develop 13C,
1H and 2H NMR methods for analysis of metabolism in relatively simple preparations such as isolated tissues. Methods for data analysis were worked out, and somewhat surprisingly, these techniques have translated quite well to in vivo applications in mice, rats and humans.

Recently the Advanced Imaging Research Center has acquired equipment to help move these concepts into two new research opportunities. In collaboration with Dr. Matthew Merritt, we are extending the metabolic analysis, developed over the years, to analysis of biochemical pathways with hyperpolarized 13C. This technology allows 13C imaging of specific metabolic pathways, offering the potential of using stable isotopes to acquire detailed metabolic information in patients. This technology has been demonstrated in human patients by the research group at UC San Francisco. The second direction is to use a high field instrument, 7T, to acquire 13C, 1H and 31P NMR studies in humans. Although there are technical challenges in working at high fields, we have confirmed that spectacular 1H spectra can be obtained, and new 13C and 31P studies in patients will become available in 2011.

Contact email: craig.malloy@utsouthwestern.edu

Research Interests

Cardiovascular radiology
MR methods for the analysis of cardiac metabolism and function
Intermediary metabolism.