About the AIRC Faculty Contacting the AIRC Mouse Imaging Core Facility Research Areas Opportunities
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About the AIRC

Academic Title Assistant Professor
Advanced Imaging Research Center
Secondary Appointment Radiology
School Southwestern Medical School
Degree Program Radiological Sciences

Matthew E. Merritt, PhD

Research Overview
The application of nuclear magnetic resonance (NMR) as a tool for measuring intermediary metabolism depends upon high NMR sensitivity for carbon-13 and deuterium nuclei. The sensitivity is governed by the applied magnetic field strength and the efficiency of the detection circuit. Recent data acquired using dynamic nuclear polarization (DNP) to enhance the magnetic resonance signal shows an increase in signal to noise of a factor of 10000 or more. Sensitivities of this magnitude would fundamentally change the types of problems we can approach with stable isotope methods. We are beginning a research program focused on using DNP for NMR analysis of metabolism. Our first papers show that hyperpolarization does provide unique opportunities to monitor enzyme catalyzed reactions with extremely high time resolution (1 second or less). These results represent a quantum leap in the power of NMR to study metabolism.

Contact email: matthew.merritt@utsouthwestern.edu

Research Interests

Hyperpolarization for NMR sensitivity enhancement Metabolomics and Efficient NMR Data Reduction
Magnetic Resonance