About the AIRC Faculty Contacting the AIRC Mouse Imaging Core Facility Research Areas Opportunities
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About the AIRC

Academic Title Assistant Instructor
Primary
Appointment
Advanced Imaging Research Center

Nishanth Sunny, PhD

Research Overview
Significant cross talk exists between nutrients, hormones and their molecular mediators to maintain energy homeostasis during health and disease. Defects in insulin signaling associated with insulin resistance and diabetes results in multiple metabolic derangements, either through altered nutrient transport or defective intracellular nutrient/molecular signaling mechanisms. These derangements are not limited to pathways of glucose and lipid metabolism, but also extend to pathways of urea and amino acid metabolism. My research interest is in identifying the shared metabolic defects contributing to the progression of insulin resistance and diabetes, especially in the liver. We use stable isotope based Mass Spectrometry and Nuclear Magnetic Resonance in combination with standard tools in molecular biology to profile glucose and mitochondrial metabolism. We study diet-induced/ genetically modified rodent models of disease under various metabolic perturbations including euglycemic hyperinsulinemic clamp and lipid challenge to tease out the metabolic alterations contributing to disease progression. My goal is to combine the functional metabolic flux information together with the several mechanisms of molecular regulation to understand the metabolic physiology during disease.

Contact: nishanth.sunny@utsouthwestern.edu

Research Interests

Profiling intermediary metabolism by stable isotopes Hepatic metabolism in insulin resistance and diabetes
Metabolomics by mass spectrometry