Combinatorial chemical synthesis and biological screens are extremely important in therapeutic and diagnostic agent developments. We apply several types of combinatorial techniques; (A) to identify high affinity and high specific peptidomimetic compounds targeting cancer cell surface receptors, as well as (B) to study and develop better contrast agents.
The development of early detection strategies, efficaous treatments, and reliable monitoring methods are major challenges in oncology. Many of the conventional methods used to detect and treat cancer have only generated limited results due to the complexity of the disease as well as un-optimized and non-specific activity of current diagnostic and therapeutic agents. A meaningful impact on cancer screening, staging, and treatment is not likely to occur until the affinity and specificity of these agents for cancer cells are increased significantly over that of normal cells. To overcome this problem, my lab aims to develop and evaluate high affinity and specific multi-site binding peptidomimetic ligands for cancer cells via a genome-wide target search as well as an unbiased selection approach. Identified ligands can later be used as therapeutic agents as well as imaging agent carriers in the clinic. We also focus on developing better contrast agents through combinatorial approaches.
The main approaches use in my lab achieving these goals are:
This lead compound development process is compliant with many cancer types such as lung, breast, prostate etc., developing global set of tools to detect, monitor and treat cancer, leading to develop personalized medication systems in the future. Combinatorial and parallel solid phase synthesis, on-bead cell screen, cell binding and functional assays and targeted imaging are some of the main techniques used in my lab. Overall, these projects cover chemical synthesis to biological investigation and ultimately address both diagnostics and therapeutic aspects of cancer medicine. This offers students/ fellows a unique opportunity to learn the "development" as well as the "application" sides of lead compound evolution process in a true chemical biology environment.
Contact email: [email protected]
|Peptidomimetics (in particular peptoids) development||Combinatorial synthesis and cell screen|
|Cancer therapy-diagnostic tool development - "Theranostics"||Novel contrast agent development|