Our Group's research is highly interdisciplinary with three main research directions
|(III) Renal Clearable Metal Nanoparticles as Multimodality in vivo Imaging Probes|
To minimize nanotoxicity, we have developed a class of luminescent metal nanoparticles that can be cleared from the body through urinary system but still serve as a new generation of contrast agents for early disease diagnosis.
(1) J. Liu, M. Yu, C. Zhou, S. Yang, X. Ning, and J. Zheng, “Passive Tumor Targeting of Renal Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance”, J. Am. Chem. Soc., 2013, 135(13), 4978-4981.
(2)C. Zhou, G. Hao, T. Patrick, J. Liu, M. Yu, S. Sun, O. Oz, X. Sun, and J. Zheng, “Near Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics”, Angew. Chem. Int. Ed., 2012, 51(40), 10118-10122.
(3) C. Zhou, M. Long, Y. Qin, X. Sun and J. Zheng, “Luminescent Gold Nanoparticles with Efficient Renal Clearance”, Angew. Chem. Int. Ed., 2011, 50(14), 3168-3172.