Spring Semester 2012
Meeting time: Monday and Wednesday 10:00 – 11:15 am
This course will review the basic principles of neural coding with special emphasis on auditory information processing.
Lectures will provide students with the appropriate background for each topic, and discussions will explore classic and modern primary papers. Workload will consist of readings, class presentations, class participation, and weekly written critiques.
This first aim of the course is to provide a complete and up-to-date understanding of the concepts involved in a well-studies aspect of brain function: sensory represenation. The focused nature of this course will be a useful supplement to a general education of brain function based on surveys of many fields. Because similar principles apply throughout the brain the detailed description of auditory coding provided by this course will serve as a conceptual starting point for thinking about other brain regions. An additional aim of this course is to relate the discussed concepts to clinically relevant issues. This course assumes only a general understanding of basic neuroscience principles and will be useful to students interested in neuroscience, audiology, communication disorders, cognitive science, developmental psychology, biology, computer science, or neural networks.
All assigned readings must be completed before each class.
Critiques -- one-fourth of final grade.
Each week you will need to type a concise, thoughtful critique of one of the papers for discussion. Support your conclusions using concrete evidence and quotations, not merely your opinion. The following outline is suggested: (1) Summarize in 1-2 sentences the key take-home message(s) of the paper. (2) Place the paper in context within the literature we have covered in class. What central problems does it address? How does it differ from other work we studied? How does it advance the field? (3) Critique the methods and conclusions. Are there any flaws in technique or logic? Are the experiments or conclusions believable? (4) Discuss the paper in terms of key concepts we have covered in class. (5) Suggest improvements or additional work. What important related questions does the paper leave open? Critique assignments should be about a page long and should be on the primary research papers not the review articles.
Individual class participation – one-half of final grade (this will be highly quantitative).
In class presentation – one fourth of final grade.
On completion of this course, students should be able to:
Topics (and papers for discussion):
1. Introduction Sensory Cortex – 1/18
a. Chapter 30 of Kandell (Principles of Neural Science)
b. Chapter 1 of The Mammalian Auditory Pathway: Neurophysiology (printouts in lab)
b. Chapter 27 and 28 of Kandell (suggested)
3. Primary Auditory Cortex - 1/25
b. Ehret G. The auditory cortex. J Comp Physiol. 1997 Dec;181(6):547-57
5. Auditory Cortex – 2/1
a. Sutter ML, et al Physiology and topography of neurons with multipeaked tuning curves in cat primary auditory cortex. J Neurophysiol. 1991 May;65(5):1207-26.
a. Phillips DP Representation of acoustic events in the primary auditory cortex. J Exp Psychol Hum Percept Perform. 1993 Feb;19(1):203-16
7. 2/8 Spectral envelope coding in cat primary auditory cortex, 1: Eur J Neurosci. 1998;10(3):926-40.
8. Temporal Processing and Forward Masking – 2/13
a. Brosch M, et al Time course of forward masking tuning curves in cat primary auditory cortex. J Neurophysiol. 1997 Feb;77(2):923-43.
b. Distributed representation of spectral and temporal information in rat primary auditory cortex Hear Res 1999 Aug;134(1-2):16-28 Kilgard MP, Merzenich MM
a. He J, et al Temporal integration and duration tuning in the dorsal zone of cat auditory cortex. J Neurosci. 1997 Apr 1;17(7):2615-25.
10. Non-Primary Auditory Fields - 2/20
a. Schreiner CE, et al Representation of amplitude modulation in the auditory cortex of the cat. II. Comparison between cortical fields. Hear Res. 1988 Jan;32(1):49-63.
b. Functional Specialization in Rhesus Monkey Auditory Cortex, Science. 2001 Apr 13;292(5515):290-3.
11. Student Presentations 2/22
12. Sound Localization - 2/27
a. Jenkins WM, et al. Role of cat primary auditory cortex for sound-localization behavior. J Neurophysiol. 1984 Nov;52(5):819-47.
b. Sound localization during homotopic and heterotopic bilateral cooling deactivation of primary and nonprimary auditory cortical areas in the cat, Malhotra S, Lomber SG., J Neurophysiol. 2007 Jan;97(1):26-43.
a. A Panoramic Code for Sound Location by Cortical Neurons Middlebrooks
14. Information Bearing Parameters - Bat - 3/5
a. O'Neill WE, et al. Encoding of target range and its representation in the auditory cortex of the mustached bat. J Neurosci. 1982 Jan;2(1):17-31.
b. Suga N Biosonar and Neural Computation in Bats, Scientific American, June, 1990
a. Yan J, et al. Corticofugal modulation of time-domain processing of biosonar information in bats. Science. 1996 Aug 23;273(5278):1100-3.
b. Suga N Auditory Neuroethology and Speech Processing 1988 Chapter 23 of Auditory Function: Neurological Baes of Hearing
16. Neuroethology - 3/19
a. Wang X, et al. Representation of a species-specific vocalization in the primary auditory cortex of the common marmoset: temporal and spectral characteristics. J Neurophysiol. 1995 Dec;74(6):2685-706.
b. Esser KH, et al. Syntax processing by auditory cortical neurons in the FM-FM area of the mustached bat Pteronotus parnellii. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14019-24.
b. Schreiner CE. Spatial distribution of responses to simple and complex sounds in the primary auditory cortex. Audiol Neurootol. 1998 Mar-Jun;3(2-3):104-22. (optional)
c. Phillips DP Sensory Representation, the auditory cortex, and speech perception, 1998 (optional)
18. Student Presentations 3/26
19. Student Presentations 3/28
20. Development and Lesion induced Plasticity – 4/2
b. Rainer Klinke, Andrej Kral, Silvia Heid, Jochen Tillein, Rainer Hartmann, Recruitment of the Auditory Cortex in Congenitally Deaf Cats by Long-Term Cochlear Electrostimulation, Science, 1999: 285(1729 – 1733)
22. Adult Plasticity - 4/9
a. Recanzone GH, et al Plasticity in the frequency representation of primary auditory cortex following discrimination training in adult owl monkeys. J Neurosci. 1993 Jan;13(1):87-103.
b. Robert C. Froemke*, Michael M. Merzenich & Christoph E. Schreiner A synaptic memory trace for cortical receptive field plasticity
a. Polley DB, Steinberg EE, Merzenich MM. Perceptual learning directs auditory cortical map reorganization through top-down influences. J Neurosci. 2006 May 3;26(18):4970-82.
b. Kilgard MP, Merzenich MM Cortical map reorganization enabled by nucleus basalis activity, Science. 1998 Mar 13;279(5357):1714-8. (optional)
c. Kaas JH Plasticity of Sensory Representation in the Auditory and Other Systems of Adult mammals, Chaper 17. (optional)
24. Coding - 4/16
a. Buonomano DV, et al Temporal information transformed into a spatial code by a neural network with realistic properties. Science. 1995 Feb 17;267(5200):1028-30.
b. Primary cortical representation of sounds by the coordination of action-potential timing. Nature 1996 Jun 13;381(6583):610-3 deCharms RC, Merzenich MM
25. Clinical implications - 4/18
a. Wakita M Recovery of function after neonatal ablation of the auditory cortex in rats. Behav Brain Res. 1996 Aug;78(2):201-9.
b. Ahissar 2000, Auditory processing parallels reading abilities in adults
a. Nagaragan 1999, Cortical auditory signal processing in poor readers
c. Merzenich M, et al Cortical plasticity underlying perceptual, motor, and cognitive skill development: implications for neurorehabilitation. Cold Spring Harb Symp Quant Biol. 1996;61:1-8 (optional)
d. Tallal P Development and Disorders of Speech and Language: Implications for neural and behavioral plasticity, 1995 (optional)
27. 4/25 Student Presentations
29. 5/2 GROUP DISCUSSION
Any schedule changes will be posted at: www.utdallas.edu/~kilgard/AuditorySP12.htm
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