Abstract View
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REPRESENTATIONAL
REMODELLING INDUCED BY DISTRIBUTED SPATIAL INPUTS IN AUDITORY CORTEX
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P.K. Pandya; R. Moucha; D.L.
Rathbun; N.D. Engineer; J.L. Vazquez; M.P. Kilgard*
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Dept Cognition &
Neuroscience, Univ Texas at Dallas, Richardson, TX, USA
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Cortical
networks employ a variety of strategies to improve the representation of
the sensory input including receptive-field plasticity and map
reorganization. Tonal stimuli associated with activation of the basal
forebrain can lead to massive map reorganization. Receptive fields can
contract or expand as a function of the sensory input statistics (Kilgard
et al, 2001). In this study, two randomly interleaved tones (2 and 14
kHz, 2.8 octave separation) that engage different spatial locations on
the cochlea were repeatedly paired with electrical activation of the
basal forebrain ~300 times a day for one month to better characterize how
spatial input patterns direct plasticity in primary auditory cortex (A1).
The cortical representation of tones was obtained by dense mapping of
multi-unit responses in each experimental (n=4) and nave control (n=15)
animal under anesthesia. The experimental group showed a large increase
over controls in the percent of cortex responding to each of the
conditioning tones, but not to tones of intermediate frequency. In
addition, the mean peak latency of A1 neurons was increased by more than
3 milliseconds (22.3 ms vs. 18.8 ms, p<0.0001). These results extend
our understanding of the network consequences of distributed inputs and
support earlier evidence that spike timing shapes cortical plasticity.
Supported by: NIH-NIDCD
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Citation:
P.K. Pandya, R. Moucha, D.L. Rathbun, N.D. Engineer, J.L. Vazquez, M.P.
Kilgard. REPRESENTATIONAL REMODELLING INDUCED BY DISTRIBUTED SPATIAL
INPUTS IN AUDITORY CORTEX Program No. 458.6. 2002 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience,
2002. Online.
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