Spring Semester 2013
Meeting time: Monday and Wednesday 8:30-9:45 am Meeting Place: GR4.301
Teaching assistant: Nicole Moreno
Weekly review session: Fridays from 1-2pm in AD2.204A
E-mail address: [email protected]
This course will review the basic principles of neural plasticity with special emphasis on cortical plasticity related to development, recovery from injury and learning.
Lectures will provide students with the appropriate background for each topic, and discussions will explore classic and modern primary papers. Workload will consist of readings, class presentations, class participation, and weekly written critiques.
This first aim of the course is to provide a detailed and up-to-date understanding of the concepts and methods involved in a well-studied aspect of brain function: plasticity. The focused nature of this course will be a useful supplement to a general education of brain function based on surveys of many fields. Because similar plasticity principles apply throughout the brain the detailed description of cortical plasticity provided by this course will serve as a conceptual starting point for thinking about other brain regions. An additional aim of this course is to relate the discussed concepts to clinically relevant issues. This course assumes only a general understanding of basic neuroscience principles and will be useful to students interested in neuroscience, communication disorders, cognitive science, developmental psychology, biology, computer science, or neural networks. It is recommended that students have taken Cellular Neuroscience and Integrative Neuroscience.
· Developmental plasticity
· Pathological plasticity
· Plasticity induced by peripheral injury
· Plasticity induced by central injury
All assigned readings must be completed before each class.
Critiques – 20% of final grade.
Each week you will need to email a concise, thoughtful critique of one of the papers for discussion. Support your conclusions using concrete evidence and quotations, not merely your opinion. The following outline is suggested: (1) Summarize the key take-home message(s) of the paper. (2) Place the paper in context within the literature we have covered in class. What central problems does it address? How does it differ from other work we studied? How does it advance the field? (3) If necessary, critique the methods and conclusions. Are there any flaws in technique or logic? Are the experiments or conclusions believable? (4) Discuss the paper in terms of key concepts we have covered in class. (5) Describe open questions and suggest additional work. Critique assignments should be about a page long and should be on the primary research papers not the review articles.
Individual class participation – 50% of final grade
In class presentation – 20% of final grade.
Attendance – 10% of final grade
On completion of this course, students should be able to:
Reading list (and chapters/papers for discussion):
1-14 Course Introduction and advice on how to read neuroscience papers
1-16 Chapter 56 Principles of Neural Science – Developmental Plasticity
1-23 Chapter 63 Principles of Neural Science – Adult Plasticity
1-28 Plasticity of ocular dominance columns in monkey striate cortex. 1977 (986 citations)
1-30 Plasticity of ocular dominance columns in monkey striate cortex. 1977 (986 citations)
2-6 Somatosensory cortical map changes following digit amputation in adult monkeys 1984 (767 citations)
Optional review article Plasticity of Sensory and Motor Maps in Adult Mammals 1991 (623 citations)
2-11 Modulation of visual cortical
plasticity by acetylcholine and noradrenaline 1986 (572 citations)
2-13 Student Presentations
2-18 Rapid Reorganization of Adult Rat Motor Cortex Somatic Representation Patterns after Motor Nerve Injury 1988 (147 citations)
2-27 Dependence of cortical plasticity on correlated activity of single neurons and on behavioral context 1992 (304 citations)
3-4 Functional MRI evidence for adult motor cortex plasticity during motor skill learning 1995 (924 citations)
3-6 Student Presentations
3-18 Cortical Map Reorganization Enabled by Nucleus Basalis Activity 1998 (588 citations)
3-20 Sleep Enhances Plasticity in the Developing Visual Cortex 2001 (196 citations)
3-25 Student Presentations
3-27 Pharmacological Modulation of Perceptual Learning and Associated Cortical Reorganization 2003 (120 citations)
4-3 Student Presentations
4-8 A synaptic memory trace for cortical receptive field plasticity 2007 (62 citations)
4-10 Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity 2007 (63 citations)
4-15 The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex 2008 (80 citations)
4-17 Developmentally degraded cortical temporal processing restored by training 2009 (10 citations)
4-29 Reversing Pathological Neural Activity Using Targeted Plasticity, 2011 (see also link)
5-1 Group Discussion
Any schedule changes will be posted at: www.utdallas.edu/~kilgard/PlasticitySP13.htm
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