and Neuroscience Program
School of Behavioral and Brain Sciences, GR41
Richardson, TX 75083
(972)883-2339 - Office
(972)883-2376 - Lab
(972)883-2491 - FAX
NINDS R43 Research Grant ($225,043) A Novel Adjunct to Physical Training to Improve Motor Recovery Following Stroke (co-PI with Navzer Engineer), 2013
Michael J. Fox Foundation for Parkinson’s Research Rapid Response Innovation Award ($75,000), Evaluation of Targeted Plasticity Therapy as a Treatment for Motor Dysfunction in Parkinson’s (co-PI with Seth Hays), 2013
NIDCD R44 Research Grant ($1,991,904), Targeted Neural Plasticity for the Treatment of Tinnitus (co-PI with Navzer Engineer), 2010
UT Dallas’ nominee for the Chancellor’s Entrepreneurship and Innovation Award, 2010
University of Texas Regents’ Outstanding Teaching Award ($30,000), 2009
NIDCD R43 Research Grant ($360,000), Targeted Neural Plasticity For The Treatment Of Tinnitus (co-PI with Navzer Engineer), 2009
Chancellor’s Council Outstanding Teaching Award ($5,000), 2008
Texas Advanced Research Program Award ($150,000), Guiding Brain Plasticity via Vagus Nerve Stimulation, 2007
Honorary Member, Golden Key International Honour Society, 2006
NIDCD Academic Research Enhancement Award ($224,000), Cortical Plasticity and Processing of Speech Sounds, 2004
John Merck Scholar Finalist ($10,000), 2003
Teaching Award, UTD School of Behavioral and Brain Sciences, 2002
Callier Scholar Award ($5,000), 2002
NIDCD Research Grant ($104,000), Cortical Plasticity and Processing of Complex Stimuli, 1999
NIDCD National Research Service Award ($70,000), 1998
Krevans Distinguished Dissertation Award ($500), UC San Francisco, 1998
National Science Foundation Fellowship ($50,000), 1994
Outstanding Geneticist of the Year, UC Berkeley, 1993
National Merit Scholar
Eagle Scout - BSA
2011-Present: Full Professor - UT Dallas
- Directing cortical plasticity to understand and treat neurological disease
2004-2011: Associate Professor - UT Dallas
- Cortical plasticity and the neural basis of speech sound processing
1999-2004: Assistant Professor - UT Dallas
- Investigation of the principles of cortical plasticity
1998: Post-doctoral Fellow - UC
- Michael Merzenich, Sooy Professor
- Cortical Representation of Spectrotemporal Stimuli
1994-1998: Doctoral Research - UC San Francisco
- Michael Merzenich, Sooy Professor
- Induction of large-scale reorganization of primary auditory cortex
by cholinergic forebrain stimulation
- Psychophysics of directed attention in tactile perception
1992-1993: Undergraduate Thesis - UC Berkeley
- Barbara Meyer, Howard Hughes Professor of Genetics
- Characterization of mutations in the synaptic vesicle protein, Rab-3 in C. elegans
- Cloning of cDNA of the C. elegans sex-determination gene, SDC-2
1991: Research Assistant - Baylor College
- Ron Davis
- Enhancer trap screen for genes expressed in drosophila mushroom bodies
1990: Research Assistant - Baylor College
- Ajay Rege
- Cloning of a cysteine protease from Schistosomiasis mansoni
1988-1989: Technician - Genosys,
- Polynucleotide synthesis
Targeting Plasticity with Vagus Nerve Stimulation to Treat Neurological Disease Progress in Brain Research, Hays SA, Rennaker RL, Kilgard MP. In Changing Brains - Applying Brain Plasticity to Advance and Recover Human Ability, Progress in Brain Research, 207 (in press).
Neural Coding of Speech Sounds. Kilgard M., Engineer C. In: Jaeger D., Jung R. (Ed.) Encyclopedia of Computational Neuroscience: Springer-Verlag Berlin Heidelberg, 2013.
Experience-Dependent Plasticity and the Auditory Cortex. KN Shepard, MP Kilgard, RC Liu, in Neural Correlates of Auditory Cognition, Springer (Eds. A. Popper, R. Fay, and Y. Cohen), Volume 45, 2013.
Auditory Environment, Stress, and Brain Plasticity. Nichols JA, Bose M, Jakkamsetti VP, Kilgard MP, Atzori M. in The Neurobiology of Stress: an Evolutionary Approach, Research Signpost, (Eds. F Aboitiz and A Dagnino-Subiabre), 2007.
Vagus Nerve Stimulation Delivered During Motor Rehabilitation Improves Recovery in a Rat Model of Stroke Khodaparast N, Hays SA, Sloan AM, Fayyaza T, Hulsey DR, Rennaker RL II, Kilgard MP. Neurorehabilitation and Neural Repair (in press).
Speech training alters tone frequency tuning in rat primary auditory cortex, Engineer CT, Perez CA, Carraway RS, Chang KQ, Roland JL, Kilgard MP. Behavioural Brain Research 258: 166–178, 2013.
Detection and Identification of Speech Sounds Using Cortical Activity Patterns, Centanni TM, Sloan AS, Reed AC, Engineer CT, Rennaker RL, Kilgard MP, PhD, Neuroscience (in press).
Similarity of Cortical Activity Patterns Predicts generalization Behavior. Engineer CT, Perez CA, Carraway RS, Chang KQ, Roland JL, Sloan AM, Kilgard MP. PLoS One. 8(10), 2013.
Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke. Khodaparast N, Hays SA, Sloan AM, Hulsey DR, Ruiz A, Pantoja M, Rennaker RL, Kilgard MP. Neurobiology of Disease, 60:80-88, 2013.
Increasing diversity of neural responses to speech sounds across the central auditory pathway. Ranasinghe KG, Vrana WA, Matney CJ, Kilgard MP. Neuroscience. 252:80-97, 2013
Cortical speech-evoked response patterns in multiple auditory fields are correlated with behavioral discrimination ability. Centanni TM, Engineer CT, Kilgard MP. J Neurophysiol. 110:177-89, 2013. (download file)
Knockdown of the dyslexia-associated gene KIAA0319 impairs temporal responses to speech stimuli in rat primary auditory cortex, Centanni TM, Booker AB, Sloan AM, Chen F, Maher BJ, Carraway RS, Khodaparast N, Rennaker RL, LoTurco JJ, Kilgard MP, Cerebral Cortex, Epub Feb 8, 2013. (download file)
Directing Neural Plasticity to Understand and Treat Tinnitus, Engineer ND, Møller AR, Kilgard MP, Hearing Research, 295:58-66, 2013.
The bradykinesia assessment task: an automated method to measure forelimb speed in rodents, Hays SA, Khodaparast N, Sloan AM, Fayyaz T, Hulsey DR, Ruiz AD, Pantoja M, Kilgard MP, Rennaker RL, Journal of Neuroscience Methods, 214:52-61, 2013. (download file)
Harnessing Plasticity to Understand Learning and Treat Disease, Kilgard MP, Trends in Neuroscience 35:715-22, 2012. (download file) (download supplement)
The isometric pull task: a novel automated method for quantifying forelimb force generation in rats, Hays SA, Khodaparast N, Sloan AM, Hulsey DR, Pantoja M, Ruiz AD, Kilgard MP, Rennaker RL, Journal of Neuroscience Methods, 212:329-337, 2012. (download file)
Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism, Banerjee A, García-Oscos F, Hall S, Roychowdhury S, Galindo LC, Kilgard MP, Atzori M, Journal of Neuropsychopharmacology (in press).
Speech discrimination after early exposure to pulsed-noise or speech, Ranasinghe KG, Carraway RS, Borland MS, Moreno NA, Hanacik EA, Miller RS, Kilgard MP, Hearing Research, 289:1-12, 2012. (download file)
Neural Mechanisms Supporting Robust Discrimination of Spectrally and Temporally Degraded Speech, Ranasinghe KG, Vrana WA, Matney CJ, Kilgard MP, J Assoc Res Otolaryngol (epub). (download file)
Different Time Scales for the Neural Coding of Consonant and Vowel Sounds, Perez CA, Engineer CT, Jakkamsetti V, Carraway RS, Perry MS, Kilgard MP, Cerebral Cortex, 2012 (epub). (download file)
Inverted-U Function Relating Cortical Plasticity and Task Difficulty. Engineer ND, Engineer CT, Reed AC, Pandya PK, Jakkamsetti V, Moucha R, Kilgard MP, Neuroscience 205:81-90, 2012. (download file)
Reorganization in Processing of Spectral and Temporal Input in the Rat Posterior Auditory Field induced by Environmental Enrichment. Jakkamsetti V, Chang KQ, Kilgard MP, Journal of Neurophysiology 107:1457-75, 2012. (download file)
Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex. Shetake J, Engineer ND, Vrana WA, Wolf JT, Kilgard MP, Experimental Neurology, 233:342-9, 2012. (download file)
Repeatedly pairing vagus nerve stimulation with a movement reorganizes primary motor cortex. Porter BA, Khodaparast N, Fayyaz T, Cheung RJ, Ahmed SS, Vrana WA, Rennaker RL 2nd, Kilgard MP, Cerebral Cortex, 22:2365-74, 2012. (download file)
Cortical activity patterns predict robust speech discrimination ability in noise. Shetake JA, Wolf JT, Cheung RJ, Engineer CT, Ram SK, Kilgard MP, European Journal of Neuroscience, 34:1823-38, 2011. (download file)
Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptors. Nichols J, Nichols AR, Smirnakis S, Engineer ND, Kilgard MP, Atzori M, Neuroscience, 189:207-14, 2011. (download file)
Cortical map plasticity improves learning but is not necessary for improved performance, Reed A, Riley J, Carraway R, Carrasco A, Perez C, Jakkamsetti V, Kilgard MP, Neuron, 14;70:121-31, 2011. (download file) (supplementary information) (Press Coverage)
Reversing pathological neural activity using targeted plasticity, Engineer ND, Riley JR, Seale JD, Vrana WA, Shetake JA, Sudanagunta SP, Borland MS, Kilgard MP, Nature, 470:101-4, 2011. (download file) (supplementary information) (Press Coverage)
Discrimination of brief speech sounds is impaired in rats with auditory cortex lesions, Porter BA, Rosenthal TR, Ranasinghe KG, Kilgard MP. Behavioural Brain Research, 219:68-74, 2011. (download file)
Effects of damage to auditory cortex on the discrimination of speech sounds by rats. Floody OR, Ouda L, Porter BA, Kilgard MP. Physiology and Behavior, 101:260-268, 2010. (download file)
Effect of the environment on the dendritic morphology of the rat auditory cortex. Bose M, Roychowdhury S, Muñoz P, Nichols J, Jakkamsetti V, Porter B, Salgado H, Kilgard MP, Aboitiz F, Dagnino-Subiabre A, Atzori M. Synapse, 64:97-110, 2010. (download file)
Chronic Stress Induces Dendritic Atrophy in the Rat Medial Geniculate Nucleus: Effects on Auditory Conditioning, Dagnino-Subiabre A, Muñoz-Llancao P, Terreros G, Wyneken U, Díaz-Véliz G, Porter B, Kilgard MP, Atzori M, Aboitiz F, Behavioral Brain Research, 203:88-96, 2009. (download file)
Cortical Activity Patterns Predict Speech Discrimination Ability, Engineer CT, Perez CA, Chen YH, Carraway RS, Reed AC, Shetake JA, Jakkamsetti V, Chang KQ, Kilgard MP. Nature Neuroscience, 11: 603-608, 2008 (download file, supplemental data, and video).
Sensory Experience Determines Enrichment-Induced Plasticity in Rat Auditory Cortex, Percaccio CR, Pruette AL, Mistry ST, Chen YH, Kilgard MP. Brain Research, 1174:76-91, 2007 (download file).
Differential Reductions in Acoustic Startle Document the Discrimination of Speech Sounds in Rats. Floody OR, Kilgard MP. Journal of the Acoustical Society of America, 122:1884-7, 2007 (download file).
Spectral and Temporal Processing in Rat Posterior Auditory Cortex. PK
Pandya, DL Rathbun, R
Plasticity in the Rat Posterior Auditory Field following Nucleus Basalis Stimulation. Puckett AC, Pandya PK, Moucha R, Dai W, Kilgard MP. Journal of Neurophysiology. 98:253-65, 2007. (download file)
Experience Dependent Plasticity Alters Cortical Synchronization. Kilgard MP, Vazquez JL, Engineer ND, Pandya PK. Hearing Research. 229:171-179, 2007. (download file)
Environmental Enrichment Selectively Increases Glutamatergic Responses in Layer II/III of the Auditory Cortex of the Rat. Nichols JA, Jakkamsetti V, Dinh L, Kilgard MP, Atzori M. Neuroscience, 145: 832-840, 2007. (download file)
Anesthesia suppresses nonsynchronous responses to repetitive broadband stimuli. Rennaker RL, Carey HL, Anderson SE, Sloan AM, Kilgard MP. Neuroscience, 145:357-69, 2007. (download file)
Neuroscientific Principles Underlying Reorganization After Brain Injury. Percaccio CR, Kilgard MP, Brain Injury Professional, 3: 26-29, 2006. (download file)
Response to Broadband Repetitive Stimuli in Auditory Cortex of the Unanesthetized Rat.
Cortical Map Reorganization Without Cholinergic Modulation. Kilgard MP. Neuron. 48:529-30, 2005.
Environmental Enrichment Increases Paired Pulse Depression in Rat Auditory Cortex. CR Percaccio, ND Engineer, AL Pruette, PK Pandya, R Moucha, DL Rathbun, MP Kilgard, Journal of Neurophysiology, 94:3590-600, 2005 (download file).
Asynchronous Inputs Alter Excitability, Spike Timing, &
Topography in Primary Auditory Cortex. PK
Sounds Contribute to Spectrotemporal Plasticity In
Primary Auditory Cortex. R Moucha,
Environmental Enrichment Improves Response Strength, Threshold, Selectivity, and Latency of Auditory Cortex Neurons. Engineer ND, Percaccio CR, Pandya PK, Moucha R, Rathbun DL, Kilgard MP. Journal of Neurophysiology, 92(1):73-82, 2004 (download file).
Cholinergic Modulation of Skill Learning and Plasticity, M.P. Kilgard, Neuron, 38(678-680), 2003.
Cortical Network Reorganization Guided by Sensory Input Features, M.P. Kilgard, P.K. Pandya, N.D. Engineer, R. Moucha, Biological Cybernetics, 87(5-6):333-43, 2002 (download file).
Order Sensitive Plasticity in Adult Primary Auditory Cortex, M.P. Kilgard, M.M. Merzenich, Proceedings of the National Academy of Sciences, 99: 3205-3209, 2002 (download file).
Dynamic categories, M.P. Kilgard, Nature, 412:693-694, 2001. (download file)
Spatial Features Control Temporal Plasticity in Auditory Cortex, M.P. Kilgard, P.K. Pandya, J.L. Vazquez, D. Rathbun, N.D. Engineer, R. Moucha, Audiology and Neuro-otology, 6:196-202, 2001. (download file)
Sensory Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex, M.P. Kilgard, P.K. Pandya, J.L. Vazquez, Gehi, A., C.E. Schreiner, M.M. Merzenich, Journal of Neurophysiology, 86: 339-353, 2001. (download file)
Distributed Representation of Spectral and Temporal Information in Rat Auditory Cortex, M.P. Kilgard, M.M. Merzenich, Hearing Research, 134(1-2): 16-28, 1999. (download file)
Plasticity of Temporal Information Processing in the Primary Auditory Cortex, M.P. Kilgard, M.M. Merzenich, Nature Neuroscience, 1(8): 727-731, 1998. (download file)
Nucleus Basalis Activity Enables Cortical Map Reorganization, M.P. Kilgard, M.M. Merzenich, Science 279(5357): 1714-1718, 1998. (download file)
Representations in Natural and Artificial Systems, P. Konig, E. Bizzi, N. Burgess, N. Franceschini, M.P. Kilgard, M. Oram, G, Sagerer, C. Scheier, Zeitschrift für Naturforschung, 53(7-8):738-51, 1998. (download file)
Sound-Induced Seizures in Serotonin 5-HT2c Receptor Mutant Mice, T.J. Brennan, W.W. Seeley, M.P. Kilgard, C.E. Schreiner and L.H. Tecott, Nature Genetics, 16(4): 387-390, 1997. (download file)
Caenorhabditis elegans rab-3 Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles, M.L. Nonet, J.E. Staunton, M.P. Kilgard, T. Fergestad, E. Jorgestad, E. Hartwig, H.R. Horvitz, B.J. Meyer, J. Neuroscience, Nov 1;17(21):8061-8073, 1997. (download file)
Anticipated Stimuli Across the Skin, M.P. Kilgard, M.M. Merzenich, Nature, V373, Feb 23, p663, 1995.
Recessive Rab3 Mutations, M.P. Kilgard, M.L. Nonet, B.J. Meyer, Worm Breeders Gazette, 13(1), p39, 1993.
System for stimulating brain plasticity. M.P. Kilgard, M.M. Merzenich, United States Patent 6,221,908, 1998.
Computer-Implemented Methods and Apparatus for Alleviating Abnormal Behaviors. M.P. Kilgard, M.M. Merzenich, S. Bao, United States Patent 7,024,398, 2006.
Timing Control for Paired Plasticity, M.P. Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W. Rosellini, United States Patent 8,489,185.
Methods, Systems, and Devices for Treating Tinnitus with VNS Pairing, M.P. Kilgard, N.D. Engineer, Pierce DM. United States Patent Application 20,100,004,705.
Systems, Methods And Devices For Paired Plasticity, M.P. Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W. Rosellini, United States Patent Application 20,100,003,656.
Methods for Enhancing Exposure Therapy Using Vagus Nerve Stimulation, C.M. Rodriguez, M.P. Kilgard, N.D. Engineer, United States Patent Application 13/095570.
2014 – 41st Neural Interfaces Conferences , Dallas, Texas, “Directing Cortical Plasticity to Understand and Treat Neurological Disease”
2014 - Macro to Micro: The Role of Spike Timing Dependent Plasticity and Neural Hypersynchrony in Disease Symposium, Association for Research in Otolarygology, San Diego, California, “Directing Cortical Plasticity to Understand and Treat Tinnitus”
2013 - Arnold Starr Lecture, University of California, Irvine, “Directing Cortical Plasticity to Understand and Treat Auditory Processing Disorders”
2013 - Neurology Grand Rounds, University of California, Irvine, “Targeting Neural Plasticity to Treat Neurological Disease”
2013 - Auditory Plasticity and Aging Workshop, National Institute for Ageing, Bethesda, Maryland, “Directing Plasticity to Treat Neurological Disease”
2013 - University of North Carolina
2013 - Emotional Disorders and Their Neural Correlates, University of Wurzburg, Rödelsee, Germany, “Directed Neural Plasticity as a Research Tool and a Clinical Therapy”
2013 – Neurosurgery Grand Rounds, University of Texas Southwestern Medical Center, Dallas, Texas, “Directed Neural Plasticity as a Research Tool and a Clinical Therapy”
2011 - Learning to Hear: The Influence of Experience and Training on Auditory Skill Conference at the Hugh Knowles Center of Northwestern University, “Directing Neural Plasticity to Understand and Treat Speech and Hearing Disorders”
2011 - Entertainment Software applied to Cognitive Neurotherapeutics Society Meeting, University of California at San Francisco, “Directing Cortical Plasticity to Understand and Treat Neurological Disease”
2004 – Federation for European Neuroscience conference- “Plasticity in Central Auditory Processing: From Neural Mechanisms to Behavioral Significance”, Lisbon, Portugal, “Sensory Experience and Cortical Plasticity”.
2002 - University of Pennsylvania Johnson Foundation for Molecular Biophysics, Department of Biochemistry and Biophysics, and Department of Neuroscience, Philadelphia, Pennsylvania, “Sensory Experience and Cortical Plasticity”
2001 - UT Southwestern Department of Psychiatry and Center for Basic Neuroscience Seminar Series, Dallas, Texas, “How Experience Shapes Brain Function”
1999-present – UTD Graduate Courses - Cellular Neuroscience, Developmental Neuroscience, Information Processing in the Auditory Cortex, Cortical Plasticity, Neural Basis of Speech Sound Processing, and Matlab for Brain Sciences.
Representational Plasticity of Marmoset and Human Vocalizations in Rat Auditory Cortex. P.K. Pandya, N.D. Engineer, R. Moucha, W. Dai, D. L. Rathbun, A. Puckett, J. L. Vazquez, Cherie R. Percaccio, M.P. Kilgard, Association for Research in Otolaryngology, Florida, 2002.
Auditory Enrichment Enhances Evoked Potential Amplitude in Rat Auditory Cortex C. R. Percaccio, N.D. Engineer, N. C. Dempsey, P.K. Pandya, M.P. Kilgard, Association for Research in Otolaryngology, Florida, 2002.
Auditory experience improves response characteristics in rat primary auditory cortex neurons, N.D. Engineer, J. Vasquez, P.K. Pandya, R. Moucha, D. Rathbun, M.P. Kilgard, Society for Neuroscience. San Diego, 2001.
Cortical Synchronization changed by Experience-Dependent Plasticity in Rat A1, J.L. Vazquez, P.K. Pandya, N.D. Engineer, R. Moucha, D. Rathbun, M.P. Kilgard, Society for Neuroscience. San Diego, 2001.
Enriched auditory experience increases selectivity, threshold and response strength of rat primary auditory cortex neurons, N.D. Engineer, J. L. Vazquez, P.K. Pandya, R. Moucha, D. Rathbun, M.P. Kilgard, Association for Research in Otolaryngology, Florida, 2001.
Parametric changes in the cross correlation strength in rat primary auditory cortex as a function of experience, J. L. Vazquez, P.K. Pandya, D. Rathbun, R. Moucha, N.D. Engineer, M.P. Kilgard, Association for Research in Otolaryngology, Florida, 2001.
Plasticity of spectrotemporal coding in primary auditory cortex enabled by cholinergic modulation, R. Moucha, P.K. Pandya, J.L. Vazquez, D. Rathbun, N.D. Engineer, M.P. Kilgard, Association for Research in Otolaryngology, Florida, 2001.