Michael P. Kilgard – Curriculum Vitae
University of
Cognition
and Neuroscience Program
School of Behavioral and Brain
Sciences, GR41
Richardson, TX 75083
(972)883-2339 - Office
(972)883-2376 - Lab
(972)883-2491 - FAX
kilgard@utdallas.edu
http://www.utdallas.edu/~kilgard/
EDUCATION:
Ph.D., Neuroscience
Program, 1998 (download dissertation)
University of
California, San Francisco
B.A. Molecular and Cell Biology
(Biochemistry), Honors Program, 1993
University of California, Berkeley
AWARDS: $5.1M in
total research funding
Michael
J. Fox Foundation for Parkinson’s Research Rapid Response Innovation Award
($75,000), Evaluation of Targeted Plasticity Therapy as a Treatment for Motor
Dysfunction in Parkinson’s, 2013
NIDCD R01 Research Grant ($1,683,000), Animal Model of Speech Sound Processing in Autism, 2010
NIDCD R44 Research Grant ($1,991,904),
Targeted Neural Plasticity for the Treatment of Tinnitus (co-PI with Navzer
Engineer), 2010
UT
Dallas’ nominee for the Chancellor’s
Entrepreneurship and Innovation Award, 2010
University of Texas Regents’
Outstanding Teaching Award ($30,000), 2009
NIDCD R43 Research Grant ($360,000), Targeted
Neural Plasticity For The Treatment Of Tinnitus
(co-PI with Navzer Engineer), 2009
Chancellor’s Council
Outstanding Teaching Award ($5,000), 2008
Texas Advanced
Research Program Award ($150,000), Guiding Brain Plasticity via Vagus Nerve
Stimulation, 2007
Honorary
Member, Golden Key International Honour Society, 2006
NIDCD Academic Research Enhancement Award
($224,000), Cortical
Plasticity and Processing of Speech Sounds, 2004
John
Merck Scholar Finalist ($10,000), 2003
James S. McDonnell Foundation Bridging Brain, Mind, and
Behavior Research Award, Brain Plasticity
and Neuro-Rehabilitation ($446,000), 2002
Teaching
Award, UTD School of Behavioral and Brain Sciences, 2002
Cure Autism Now Foundation: Sensory Experience,
Behavioral Therapy and Neural Plasticity: Implications for Autism
Remediation ($80,000), 2002
Callier Scholar Award ($5,000), 2002
NIDCD Research Grant ($104,000), Cortical
Plasticity and Processing of Complex Stimuli, 1999
NIDCD National Research Service Award
($70,000), 1998
Krevans Distinguished Dissertation Award ($500), UC San
Francisco, 1998
National
Science Foundation Fellowship ($50,000), 1994
Outstanding
Geneticist of the Year, UC Berkeley, 1993
National
Merit Scholar
Eagle
Scout - BSA
RESEARCH:
2011-Present: Full Professor - UT Dallas
- Directing cortical plasticity to understand and treat
neurological disease
2004-2011: Associate Professor - UT Dallas
- Cortical plasticity and the neural basis of speech sound
processing
1999-2004: Assistant Professor - UT Dallas
- Investigation of the principles of cortical plasticity
1998: Post-doctoral Fellow - UC
- Michael Merzenich, Sooy Professor
- Cortical
Representation of Spectrotemporal Stimuli
1994-1998: Doctoral Research - UC San Francisco
- Michael Merzenich, Sooy Professor
- Induction of
large-scale reorganization of primary auditory cortex
by
cholinergic forebrain stimulation
- Psychophysics
of directed attention in tactile perception
1992-1993: Undergraduate Thesis - UC Berkeley
- Barbara Meyer,
Howard Hughes Professor of Genetics
-
Characterization of mutations in the synaptic vesicle protein, Rab-3 in C. elegans
- Cloning of cDNA of the C. elegans
sex-determination gene, SDC-2
1991: Research Assistant - Baylor College
of Medicine
- Ron Davis
- Enhancer trap
screen for genes expressed in drosophila mushroom bodies
1990: Research Assistant - Baylor College
of Medicine
- Ajay Rege
- Cloning of a cysteine
protease from Schistosomiasis mansoni
1988-1989: Technician - Genosys,
Inc. -
- Polynucleotide
synthesis
PUBLICATIONS:
Book Chapters:
Experience-Dependent Plasticity and the Auditory Cortex. KN Shepard, MP Kilgard, RC Liu, in Neural Correlates of Auditory Cognition, Springer (Eds. A. Popper,
R. Fay, and Y. Cohen), Volume 45, 2013.
Auditory Environment, Stress, and Brain Plasticity. Nichols JA,
Bose M, Jakkamsetti VP, Kilgard MP, Atzori M. in The Neurobiology of Stress: an Evolutionary
Approach, Research Signpost, (Eds. F Aboitiz and
A Dagnino-Subiabre), 2007.
Cortical Plasticity and Rehabilitation. Moucha
R, Kilgard MP, in Reprogramming
the Brain, Progress in Brain Research,
Elsevier, (Ed. A. Moller), 157:111-122, 2006 (download file).
How Sensory Experience Shapes Cortical
Representations, MP Kilgard, in Neuropsychology
of Memory, Guilford Press (Eds. L.R. Squire and D.L. Schacter), 2002. (download
file)
Articles: (Search PubMed or Google Scholar)
Cortical speech-evoked
response patterns in multiple auditory fields are correlated with behavioral
discrimination ability. Centanni TM, Engineer CT, Kilgard
MP. J Neurophysiol. Epub Apr
17, 2013.
Knockdown of the
dyslexia-associated gene KIAA0319 impairs temporal responses to speech stimuli
in rat primary auditory cortex, Centanni TM, Booker AB, Sloan AM, Chen F,
Maher BJ, Carraway RS, Khodaparast N, Rennaker RL, LoTurco JJ, Kilgard MP, Cerebral
Cortex, Epub Feb 8,
2013.
Harnessing
Plasticity to Understand Learning and Treat Disease, Kilgard MP, Trends in Neuroscience 35:715-22, 2012.
Directing
Neural Plasticity to Understand and Treat Tinnitus, Engineer ND, Møller AR, Kilgard MP, Hearing
Research, 295:58-66, 2013.
The bradykinesia
assessment task: an automated method to measure forelimb speed in rodents, Hays
SA, Khodaparast N, Sloan AM, Fayyaz T, Hulsey DR, Ruiz AD, Pantoja M, Kilgard
MP, Rennaker RL, Journal of Neuroscience
Methods, (in press).
The isometric pull task: a
novel automated method for quantifying forelimb force generation in rats,
Hays SA, Khodaparast N, Sloan AM, Hulsey DR, Pantoja M, Ruiz AD, Kilgard MP,
Rennaker RL, Journal of Neuroscience
Methods, 212:329-337, 2012.
Impairment of cortical GABAergic synaptic transmission in an environmental rat
model of autism, Banerjee A, García-Oscos F, Hall
S, Roychowdhury S, Galindo LC, Kilgard MP, Atzori M, Journal of Neuropsychopharmacology
(in press).
Speech
discrimination after early exposure to pulsed-noise or speech, Ranasinghe
KG, Carraway RS, Borland MS, Moreno NA, Hanacik EA,
Miller RS, Kilgard MP, Hearing Research,
289:1-12, 2012. (download
file)
Neural
Mechanisms Supporting Robust Discrimination of Spectrally and Temporally
Degraded Speech, Ranasinghe KG, Vrana WA, Matney CJ, Kilgard MP, J Assoc Res Otolaryngol (epub). (download file)
Different
Time Scales for the Neural Coding of Consonant and Vowel Sounds, Perez CA,
Engineer CT, Jakkamsetti V, Carraway
RS, Perry MS, Kilgard MP, Cerebral Cortex,
2012 (epub). (download file)
Inverted-U Function Relating Cortical Plasticity and Task Difficulty. Engineer ND, Engineer CT, Reed AC, Pandya PK, Jakkamsetti V, Moucha R, Kilgard
MP, Neuroscience 205:81-90, 2012. (download file)
Reorganization in Processing of Spectral and Temporal Input in the
Rat Posterior Auditory Field induced by Environmental Enrichment. Jakkamsetti V, Chang KQ, Kilgard
MP, Journal of Neurophysiology
107:1457-75, 2012. (download
file)
Pairing
tone trains with vagus nerve stimulation induces temporal plasticity in
auditory cortex. Shetake J, Engineer ND, Vrana
WA, Wolf JT, Kilgard MP, Experimental
Neurology, 233:342-9, 2012. (download file)
Repeatedly
pairing vagus nerve stimulation with a movement reorganizes primary motor
cortex. Porter BA, Khodaparast N, Fayyaz T, Cheung RJ, Ahmed SS, Vrana WA,
Rennaker RL 2nd, Kilgard MP, Cerebral
Cortex, 22:2365-74, 2012. (download file)
Cortical
activity patterns predict robust speech discrimination ability in noise. Shetake JA, Wolf JT, Cheung RJ, Engineer CT, Ram SK, Kilgard MP, European Journal of Neuroscience,
34:1823-38, 2011. (download
file)
Vagus
nerve stimulation modulates cortical synchrony and excitability through the
activation of muscarinic receptors. Nichols J, Nichols AR, Smirnakis S, Engineer ND, Kilgard MP, Atzori
M, Neuroscience, 189:207-14, 2011. (download file)
Cortical
map plasticity improves learning but is not necessary for improved performance,
Reed A, Riley J, Carraway R, Carrasco A, Perez C, Jakkamsetti V, Kilgard MP, Neuron, 14;70:121-31, 2011. (download file) (supplementary
information) (Press
Coverage)
Reversing pathological neural activity using targeted plasticity, Engineer ND, Riley JR, Seale JD, Vrana WA, Shetake
JA, Sudanagunta SP, Borland MS, Kilgard MP, Nature, 470:101-4, 2011. (download file)
(supplementary information) (Press Coverage)
Discrimination
of brief speech sounds is impaired in rats with auditory cortex lesions,
Porter BA, Rosenthal TR, Ranasinghe KG, Kilgard MP. Behavioural Brain Research, 219:68-74, 2011. (download file)
Effects of damage to auditory cortex on the discrimination of
speech sounds by rats. Floody OR, Ouda L, Porter BA, Kilgard MP. Physiology and Behavior, 101:260-268, 2010. (download file)
Effect of the environment on the dendritic morphology of the rat
auditory cortex. Bose M, Roychowdhury S,
Muñoz P, Nichols J, Jakkamsetti V, Porter B, Salgado
H, Kilgard MP, Aboitiz F, Dagnino-Subiabre
A, Atzori M. Synapse,
64:97-110, 2010. (download file)
Chronic
Stress Induces Dendritic Atrophy in the Rat Medial Geniculate Nucleus: Effects
on Auditory Conditioning, Dagnino-Subiabre A, Muñoz-Llancao
P, Terreros G, Wyneken U, Díaz-Véliz G, Porter B, Kilgard MP, Atzori
M, Aboitiz F, Behavioral
Brain Research, 203:88-96, 2009. (download file)
Cortical
Activity Patterns Predict Speech Discrimination Ability, Engineer CT, Perez
CA, Chen YH, Carraway
RS, Reed AC, Shetake JA, Jakkamsetti
V, Chang KQ, Kilgard MP. Nature Neuroscience, 11: 603-608,
2008 (download file, supplemental data,
and video).
Sensory
Experience Determines Enrichment-Induced Plasticity in Rat Auditory Cortex,
Percaccio CR, Pruette AL, Mistry ST, Chen YH, Kilgard MP. Brain Research, 1174:76-91, 2007 (download file).
Differential
Reductions in Acoustic Startle Document the Discrimination of Speech Sounds in
Rats. Floody OR, Kilgard MP. Journal of the Acoustical Society of America,
122:1884-7, 2007 (download file).
Spectral and Temporal Processing in Rat Posterior Auditory Cortex. PK
Pandya, DL Rathbun, R
Plasticity in the Rat Posterior Auditory Field following Nucleus Basalis Stimulation.
Puckett AC, Pandya PK, Moucha R, Dai W, Kilgard MP. Journal of Neurophysiology. 98:253-65,
2007. (download
file)
Experience
Dependent Plasticity Alters Cortical Synchronization. Kilgard MP, Vazquez
JL, Engineer ND, Pandya PK. Hearing
Research. 229:171-179, 2007. (download file)
Environmental Enrichment Selectively Increases Glutamatergic
Responses in Layer II/III of the Auditory Cortex of the Rat. Nichols JA, Jakkamsetti V, Dinh L, Kilgard MP, Atzori M. Neuroscience, 145: 832-840, 2007. (download file)
Anesthesia
suppresses nonsynchronous responses to repetitive broadband stimuli.
Rennaker RL, Carey HL, Anderson SE, Sloan AM, Kilgard MP. Neuroscience,
145:357-69, 2007. (download
file)
Neuroscientific
Principles Underlying Reorganization After Brain Injury. Percaccio
CR, Kilgard MP, Brain Injury
Professional, 3: 26-29, 2006. (download file)
Response to Broadband Repetitive Stimuli in Auditory Cortex of the Unanesthetized Rat.
Cortical
Map Reorganization Without Cholinergic Modulation.
Kilgard MP. Neuron. 48:529-30, 2005.
Environmental
Enrichment Increases Paired Pulse Depression in Rat Auditory Cortex. CR Percaccio, ND Engineer, AL Pruette,
PK Pandya, R Moucha, DL Rathbun,
MP Kilgard, Journal of Neurophysiology, 94:3590-600, 2005 (download
file).
Asynchronous Inputs Alter Excitability, Spike Timing, &
Topography in Primary Auditory Cortex. PK
Pandya, R
Background
Sounds Contribute to Spectrotemporal Plasticity In
Primary Auditory Cortex. R Moucha,
PK
Environmental
Enrichment Improves Response Strength, Threshold, Selectivity, and Latency of
Auditory Cortex Neurons. Engineer ND, Percaccio
CR, Pandya PK, Moucha R, Rathbun
DL, Kilgard MP. Journal of
Neurophysiology, 92(1):73-82, 2004 (download file).
Cholinergic Modulation of Skill Learning and Plasticity, M.P. Kilgard, Neuron,
38(678-680), 2003.
Cortical
Network Reorganization Guided by Sensory Input Features, M.P. Kilgard, P.K.
Pandya, N.D. Engineer, R. Moucha, Biological Cybernetics, 87(5-6):333-43,
2002 (download file).
Order Sensitive Plasticity in Adult Primary Auditory Cortex, M.P. Kilgard, M.M. Merzenich, Proceedings of the National Academy of Sciences, 99: 3205-3209, 2002 (download file).
Dynamic categories, M.P. Kilgard, Nature, 412:693-694, 2001. (download file)
Spatial
Features Control Temporal Plasticity in Auditory Cortex, M.P. Kilgard, P.K.
Pandya, J.L. Vazquez, D. Rathbun, N.D. Engineer, R. Moucha, Audiology and Neuro-otology,
6:196-202, 2001. (download
file)
Sensory
Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex,
M.P. Kilgard, P.K. Pandya, J.L. Vazquez, Gehi, A.,
C.E. Schreiner, M.M. Merzenich, Journal of
Neurophysiology, 86: 339-353, 2001. (download file)
Distributed
Representation of Spectral and Temporal Information in Rat Auditory Cortex,
M.P. Kilgard, M.M. Merzenich, Hearing Research,
134(1-2): 16-28, 1999. (download file)
Plasticity
of Temporal Information Processing in the Primary Auditory Cortex, M.P.
Kilgard, M.M. Merzenich, Nature Neuroscience,
1(8): 727-731, 1998. (download file)
Nucleus
Basalis Activity Enables Cortical Map Reorganization,
M.P. Kilgard, M.M. Merzenich, Science
279(5357): 1714-1718, 1998. (download
file)
Representations in Natural and Artificial Systems, P. Konig,
E. Bizzi, N. Burgess, N. Franceschini,
M.P. Kilgard, M. Oram, G, Sagerer,
C. Scheier, Zeitschrift
für Naturforschung,
53(7-8):738-51, 1998. (download file)
Sound-Induced
Seizures in Serotonin 5-HT2c Receptor Mutant Mice, T.J. Brennan, W.W.
Seeley, M.P. Kilgard, C.E. Schreiner and L.H. Tecott,
Nature Genetics, 16(4): 387-390, 1997. (download file)
Caenorhabditis elegans
rab-3 Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of
Vesicles, M.L. Nonet, J.E. Staunton, M.P.
Kilgard, T. Fergestad, E. Jorgestad,
E. Hartwig, H.R. Horvitz, B.J. Meyer, J.
Neuroscience, Nov 1;17(21):8061-8073, 1997. (download file)
Anticipated Stimuli Across the Skin, M.P. Kilgard, M.M. Merzenich,
Nature, V373, Feb 23, p663, 1995.
Recessive Rab3
Mutations, M.P. Kilgard, M.L. Nonet, B.J. Meyer, Worm
Breeders Gazette, 13(1), p39, 1993.
Patents:
System for stimulating brain plasticity. M.P. Kilgard, M.M. Merzenich,
United States Patent 6,221,908, 1998.
Computer-Implemented Methods and Apparatus for Alleviating Abnormal
Behaviors. M.P. Kilgard, M.M. Merzenich, S. Bao, United States
Patent 7,024,398, 2006.
Systems,
Methods and Devices for Treating Tinnitus, M.P. Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W. Rosellini, United
States Patent Application 20,100,004,705.
Systems,
Methods And Devices For Paired Plasticity, M.P. Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W. Rosellini, United
States Patent Application 20,100,003,656.
Timing Control for Paired Plasticity, M.P.
Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W.
Rosellini, United States Patent Application 20,100,004,717.
Methods for Enhancing Exposure Therapy Using Vagus Nerve
Stimulation, C.M. Rodriguez, M.P. Kilgard, N.D.
Engineer, United States Patent Application 13/095570.
Dissertations
Supervised:
Environmental and training-induced plasticity in primary auditory
cortex, Navzer D Engineer, 2004. (download file) (Fall 1999 - Fall 2004)
Speech sound representation and experience-dependent plasticity in
the rat auditory system, Pritesh K Pandya, 2005 (NIH
predoctoral funding). (download file) (Fall 1999 – Spring 2005)
Long-Term
and Short-Term Plasticity Induced by Experience with Spectrotemporally
Complex Sounds in Rat Auditory Cortex, Raluca Moucha, 2006. (download file) (Spring 2001 - Spring 2006)
Environmental
Enrichment Increases Response Strength and Paired Pulse Depression of Auditory
Cortex Neurons, Cherie R Percaccio, 2006. (download file) (Fall 2001 - Spring 2006)
Plasticity in the Auditory Cortex and Changes in Perceptual
Discrimination after Nucleus Basalis Stimulation in
Rats, Amanda Reed, 2008. (download file) (Fall 2002 - Summer 2008)
Speech
Sound Coding and Training-Induced Plasticity in Primary Auditory Cortex,
Crystal Engineer, 2008. (download file) (Fall 2003 - Fall
2008)
Pharmacological and Sensory Stimulation of Auditory Cortex
Plasticity in Adult Rats, Vikram
Jakkamsetti, 2008. (download file) (Fall 2003 - Fall
2008)
Changes Caused by Cortical Damage and Event Paired
Vagus Nerve Stimulation, Ben Porter, 2011. (Summer 2006 -
Spring 2011)
Cortical Processing of Speech Sounds in Adverse
Conditions, Jai Shetake, 2011. (Fall 2006 - Spring
2011)
Neural Mechanisms Supporting Robust Discrimination
of Speech, Kamalini Ranasinghe, 2012. (Fall 2008 - Spring 2012)
INVITED SCIENTIFIC PRESENTATIONS:
2013 - University of North Carolina
Neuroscience Center Seminar Series2010 – Crystal
Charity Ball Autism Project, Dallas, Texas, “Speech Sound Processing
in Autism”
2008 – Pediatric
Academic Societies Meeting, Honolulu, Hawaii, “Neural Plasticity in
Animal Models”.
2008 – Healthy Minds
Conference, Sarasota, Florida, “Neural Processing of Speech Sounds”.
TEACHING
EXPERIENCE:
2001-present
– Faculty Advisor for the Eugene
McDermott Scholars Program.
1996-1998
– Invited lecturer on cortical plasticity, City College of San Francisco.
1994
– Teaching assistant, Neuroscience for Pharmacists, UC San Francisco.
PUBLIC
PRESENTATIONS:
2010
– Bodies
the Exhibition, Dallas, Texas, “The Brain: An Owner’s Guide”
2003
– The Brain: An Owner’s Guide, Center
for BrainHealth Lecture Series, Dallas, Texas, “How Your Brain
Learns”.
2003 – Brain Health, Glen
Mitchell Show, Public Radio Station KERA Dallas, Texas.
2003
– Discoveries & Hope for Brain Health, The
McCuistion Program, Public Television, Dallas, Texas.
2001 - Learning
Brain Expo (keynote speaker), San Antonio, Texas, "Learning and Brain
Plasticity"