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18.10.2013

New paper

Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0 years, respectively) participants.According to the tinnitus questionnaire (TQ) score grade,LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD/LOT participants than in LD/LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dorsolateral prefrontal cortex were activated more in HD/EOT than in LD/EOT for the delta/beta and gamma frequency bands, respectively. Even with the same amount of tinnitus-related distress level, responsible neural substrates are different according to the onset age. These differences may be important for exploring different target areas of treatment according to tinnitus onset age, as well as for conducting similar studies on other pathologies, such as depression or pain.

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05.10.2013

New paper

A new paper on the treatment of fibromyalgia patients using occipital nerve stimulation was accepted for Neuromodulation. The goal of this study was to evaluate the effectiveness of occipital nerve stimulation (ONS) as a surgical treatment for fibromyalgia in a placebo controlled design with a six-month follow up. 11 patients were selected, based on the ACR-90 criteria and implanted with an occipital nerve trial-lead stimulator. Baseline scores for pain, mood and fatigue were acquired and patients were randomized in a 10-week double-blinded crossover design with placebo and effective, sub-sensory threshold stimulation (no paresthesias). After finalizing the trial, nine patients were implanted permanently; evaluation was performed prior to surgery and at six months after surgery for pain, fatigue, mood, of the number of trigger points and overall morbidity.Our data strongly suggests that ONS is beneficial in the treatment of fibromyalgia, that the beneficial effects are stable at six months after permanent implantation and qub-sensory threshold stimulation is feasible in designing a placebo controlled trial.