Date	Topic	Reading list
Aug 23	Introductory remarks, mechanics of the seminar	O'Keefe & Nadel: The hippocampus as a cognitive map.
Aug 30	Classical studies of spatial learning	Tolman (review): "Cognitive maps in rats & men."
		Tolman et al., "Place learning vs. response learning."
		O'Keefe & Nadel (review): "Spatial behaviour."
Sep 6	Defining studies of spatial learning: Dave Olton et al.	"Spatial memory and radial maze performance of rats."
		"Food-searching strategies in young rats..."
		"Intramaze cues and odor trails fail to direct choice behavior..."
		"A disconnection analysis of hippocampal function."
		"Hippocampal function required for nonspatial working memory."
Sep 13	The modern era: Richard Morris, Carol Barnes, Michaela Gallagher	Morris: "Spatial localization does not require the presence of local cues."
		Morris: Parlays maze design into 2 quick Nature papers...
		Barnes et al.:"Chronic treatment...effects on memory..."
		Poe et al.:"Partial hippocampal inactivation..."
		Gallagher & Rapp: "The use of animal models to study...cognition."
Sep 20	Place cells 1: John O'Keefe (discovery, cues, maps)	O'Keefe & Dostrovsky: "The hippocampus as a spatial map. Preliminary evidence..."
		O'Keefe & Conway: "On the trail of the hippocampal engram."
		Maguire et al.:"Human spatial navigation: Cognitive maps..."
		O'Keefe:"Do hippocampal...cells signal non-spatial...information?"
Sep 27	Place cells 2: Jim Ranck, Phil Best, Tres Thompson ("The very Best")	Fox & Ranck: "Electrophysiological characteristics of hippocampal complex-spike & theta cells."
		Best:"Spatial correlates of hippocampal unit activity..."
		Best:"Placing hippocampal single-unit studies in a historical context."
		Ranck:"Head direction cells in the deep...dorsal presubiculum..."
		Ranck:"The positional firing properties of medial entorhinal neurons..."
		Thompson:"Place cells and silent cells in the hippocampus..."
		Thompson:"Long-term stability of the place-field activity of single units..."
Oct 4	Place cells 3: Bruce McNaughton et al. I: (directionality, plasticity)	McNaughton et al.: "The stereotrode:...for...isolation of several single units..."
		McNaughton et al.:"Hippocampal granule cells are necessary for...learning but not for [place fields]..."
		McNaughton et al.:"Cortical-hippocampal interactions and cognitive mapping..."
Oct 11	Place cells 4: Bob Muller, Gus Pavlides (cues, plasticity, sleep)	Muller et al.: "...directional firing properties of hippocampal place cells..."
		Fenton & Muller:"Place cell discharge is extremely variable..."
		Bostock et al.:"Experience-dependent modifications of hippocampal place cell firing."
		Muller & Kubie:"...place cells...predict the future position of freely moving rats."
		Liu et al.:"Seizure-induced changes in place cell physiology..."
		Pavlides & Winson:"...place cell firing in the awake state on...cells during...sleep..."
Oct 18	Place cells 5: Sam Deadwyler, Howard Eichenbaum (beyond spatial)	Christian & Deadwyler:"Behavioral functions and hippocampal cell types..."
		Deadwyler & Hampson:"Anatomic model of hippocampal encoding of spatial information."
		Hampson et al.:"Distribution of spatial and nonspatial information in dorsal hippocampus."
		Kuperstein & Eichenbaum:"Unit activity...recorded w. a 24-channel microelectrode."
		Eichenbaum et al.:"...hippocampal unit activity in rats performing an odor-discrimination task."
		Otto & Eichenbaum:"Neuronal activity in the hippocampus during DNMTS performance in rats..."
Oct 25	Place cells 6: McNaughton et al. II (remapping, outer space, etc.)	Redish et al.:Dynamics of hippocampal ensemble activity realignment: time versus space.
		Sharp:Subicular cells generate similar spatial firing patterns in 2...distinct environments...
		Moser et al.:"A test of the reverberatory activity hypothesis for hippocampal place cells."
		Maurer et al.:"Self-motion and...spatial scaling along the septo-temporal axis of the hippocampus."
		Knierim et al.:"3-dimensional spatial selectivity of hippocampal neurons during space flight."
Nov 1	Place cells 7: The rest of the world (multiple issues)	Shapiro et al.:"Cues that hippocampal place cells encode..."
		Buzsaki:"Theta rhythm of navigation: Link between..."
		Hasselmo:"What is the function of hippocampal theta rhythm..."
		Jones & Wilson:"Phase precession of medial prefrontal cortical activity relative to...theta..."
		Cooper & Mizumori:"Temporary inactivation of retrosplenial cortex...transient reorganization..."
		Poucet et al.:"Place cells, neocortex and spatial navigation: A short review."
Nov 8	Primate place cells / NMDA receptors & spatial learning	Rolls:"Spatial view cells...in the primate hippocampus."
		Tamura et al.:"Spatial responsiveness of monkey hippocampal neurons..."
		Yanike et al.:"Representation of well-learned information in monkey hippocampus."
		Ludvig & Tang:"...electrophysiological changes in freely behaving rat during...dialysis of NMDA."
		Ekstrom et al.:"NMDA...antagonism blocks experience-dependent expansion of...place fields."
		Yan et al.:"Place-cell impairment in GluR2 mutant mice."
Nov 15	SFN Meeting: Washington, D.C.	NO CLASS MEETING--THINK DIFFERENT!
Nov 22	Aging & spatial learning	Tanila et al.:"Discordance of spatial representation in ensembles of hippocampal place cells."
		Wilson et al.:"Age-associated alterations of hippocampal place cells are subregion specific."
		Shen et al.:"The effect of age on experience-dependent plasticity of hippocampal place cells."
		Yan et al.:"Aging effects on spatial tuning of hippocampal place cells in mice."
		Barnes:"...synaptic proteins...a window on synaptic effectiveness in the aged hippocampus?"
		Taube:"Space, the final hippocampal frontier?"
Nov 29	Protein & gene expression & spatial learning	Tsien et al.:"Subregion- and cell type-restricted gene knockout in mouse brain."
		Rotenberg et al.:"Mice expressing activated CaMKII...don't form stable place cells in CA1..."
		McHugh et al.:"Impaired hippocampal representation of space in CA1-specific NR1 knockout..."
		Ribiero et al.:"Induction of...LTP during waking leads to increased...zif-268 expression during REM."
		Vazdarjanova et al.:"Experience-dependent...expression of...Arc and Homer in hippocampus..."
		Eichenbaum & Harris:"Toying with memory in the hippocampus."