We focus on integrating nanoscale elements of electronics, chemistry, and biology. Such nano-bio-engineering fusion may provide rare opportunities to explore new science and applications. Currently, we mostly focus on Si based nanoelectronic biosensor and biochips for protein and DNA detection towards low cost and portable disease diagnostics. Other projects include jetting rollable nanoimprint process and systems and fabrication of nanomaterials for biomedical and emering applications.


Nanofabrication and Nano-devices
"Top-down" or nanolithographic fabrication based on e-beam lithography and nanoimprint lithography is applied to make single digit (2-10 nm) low-dimensional structures with size comparable to chemical synthesis, but with better controlability and uniformity. We also investigate material property, nano-devices, and "strange" phenomena emerged with these nanostructures.

Publications: Hu 2004, Hu 2005, Tao 2008, Trivedi 2011, Trivedi 2009.

Nanoelectronic Biosensor, Chips
Since 2007, we have worked on the design, fabrication, and testing lithographically defined nano-FETs such as Si nanowires or finFETs. We also develop surface chemistry for nano-FETs to detect pH, protein, DNA, and small molecules for molecular diagnostics, food safety, and enviromental monitoring. Nanoelectronic bio-chip is ultrasensitive, fast, low cost, and ultra-portable.

Publications: Tian 2011, Regonda 2008, Regonda 2013, Yang 2012

Nanoimprinted Organic Solar Cells
We use nanoimprint to create an optimal nano-morphology of vertically interdigitized and bi-continuous donor and acceptor materials for high efficiency in organic solar cells. Nanoimprint can simutaneously control the morphology and chain alignments in polymer, which is a challenge for chemical methods. We are also developing rollable nano-printing to enable low cost fab.

Publications: Yang 2010, Zhou 2010, Aryal 2009, Aryal 2008, Yang 2012

Biomaterials for Nanomedicine
Combination of top-down nanoimprint lithography and bottom-up self-assembly is developed to make uniform and shape-specific polymer nanoparticles for nanomedicine applications. Molecular agents and drugs can be encapsulated in these polymer nanoparticle platforms for targetted delivery and imaging. We also develop jet roller nanoprinting tool for high-throughput particle production.

Publications: Tao 2011, Tao 2010, Buyukserin 2009, Tao 2007, Hu 2013

Nanostructures for Tissue Engin.
Nanoimprint is used to make nanogratings as scaffolds for tissue engineering. By elongating pillars during mold release, very high aspect ratio pillars like nano-grass are made. Gratings can guide cell alignment and elongation, while nano-grass strongly inhibits cell adhesion despite of surface chemistry. These nanoscaffolds serve as a testbed to study cell-substratrum interaction at the nanoscale.

Publications: Hu 2010, Crouch 2009, Hu 2005

 

Acknowledgements
Our research is financially supported by the following federal and state agencies, and companies.

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Moncrief Foundation, Texas Medical Consortium

Nanoscale Integration Laboratory © 2005-2013 Wenchuang (Walter) Hu, Last update: Sept, 2013