The University of Texas at Dallas School of Behavioral and Brain Sciences

Theodore J. Price

Professor
Program Head, Neuroscience BS
Eugene McDermott Professor

Research Interests

The molecular mechanisms that cause pain to become chronic; developing therapeutics to target these mechanisms

Curriculum Vitae

Biography

Dr. Theodore Price is one of the foremost researchers in understanding how neuronal plasticity alters the way the brain receives nociceptive information from the sensory system and how this relates to chronic pain in human patients. Dr. Price has discovered several novel targets that regulate the excitability of sensory neurons after injury and that mediate plasticity in the central nervous system that cause pain to become chronic. Dr. Price’s work has been published in numerous scientific journals and his research program has been supported by the National Institutes of Health and the Migraine Research Foundation. He serves as an editor for several leading industry journals and received the Patrick D. Wall Young Investigator Award from the International Association for the Study of Pain. Dr. Price also received the John C. Liebeskind Early Career Scholar Award from the American Pain Society, the Buhrmester Rising Star Award from UT Dallas, and has been named a permanent member of the NIH Somatosensory and Pain Study Section. Dr. Price earned his bachelor’s degree from UT Dallas and his doctoral degree in pharmacology from the University of Texas Health Science Center at San Antonio.

Recent and Selected Representative Publications

Articles in Peer-Refereed Journals

Shiers S, Pradhan G, Mwirigi J, Mejia GL, Ahmad A, Kroener S, Price TJ (2018) Neuropathic pain creates an enduring prefrontal cortex dysfunction corrected by the type II diabetic drug metformin but not by gabapentin. Journal of Neuroscience. 38 (33) 7337-7350.

Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh EL, Dworkin RH (2018) Transition to chronic pain: opportunities for the development of novel therapeutics. Nature Reviews Neuroscience. 19. 383-384.

Megat S, Shiers S, Moy JK, Barragan-Iglesias P, Pradhan G, Seal RP, Dussor G, Price TJ (2018) A critical role for dopamine D5 receptors in pain chronicity in male mice. Journal of Neuroscience. 38(2). 379-397.

Moy, JK, Khoutorsky A, Asiedu MN, Black, BJ, Kuhn JL, Barragan-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ (2017) The MNK-eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain. Journal of Neuroscience. 37(31) 7481-7499.

Hanamura K, Washburn HR, Sheffler-Collins SI, Xia N, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB (2017) Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain. PLoS Biology. 15(7) e2002457.

Kim, J.V., Tillu, D.V., Quinn, T.L., Mejia, G.L., Shy, A., Asiedu, M.N., Murad, E., Schumann, A.P., Totsch, S.K., Sorge, R., Mantyh, P.W., Dussor, G., Price T.J. (2015) Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. Journal of Neuroscience, 35(16) 6307-6317.