School of Behavioral and Brain Sciences

Colleen G. Le Prell

Professor
Program Head, Audiology AuD
Emilie and Phil Schepps Professorship in Hearing Science

Research Interests

Hearing Loss Prevention

Curriculum Vitae

Contact

Email: [email protected]
Phone: 214-905-3018
Office: CD_J216
Campus Mail Code: CD

Biography

Dr. Colleen Le Prell is one of the leading researchers in the area of hearing loss prevention. Her work has emphasized the identification of cell death pathways activated by noise, and assessment of therapeutic agents that prevent cell death and hearing loss. Recently, Dr. Le Prell completed a pre-clinical study assessing prevention of age-related hearing loss, noise-induced hearing loss, and their interactions, using two dietary supplements. In parallel, she led two clinical trials assessing potential prevention of temporary music-player induced changes in hearing; one study assessed an investigational new drug agent, and the other assessed a dietary supplement. Dr. Le Prell is the president-elect of the National Hearing Conservation Association. She has served as the lead editor on the Springer Handbook of Auditory Research edition titled Noise-Induced Hearing Loss: Scientific Advances, co-editor on a recent volume in the Springer series, Oxidative Stress in Applied Basic Research and Clinical Practice, titled Free Radicals in ENT Pathology, and also director of education for the National Hearing Conservation Association. Dr. Le Prell received her bachelor’s degree from the University of Minnesota at Morris and her master’s and doctoral degrees from the University of Michigan.

Recent and Selected Representative Publications

Recent Articles in Peer-Reviewed Journals

Kil, J., Lobarinas, E., Spankovich, C., Griffiths, S., Antonelli, P.J., Lynch, E.D., Le Prell, C. G. (2017). Safety and efficacy of Ebselen for the prevention of noise-induced hearing loss: A randomized double blind placebo-controlled phase 2 clinical trial, The Lancet,390(10098):969-979.

Grinn, S., Baker, J., Wiseman, K., and Le Prell, C. G. (2017). Hidden hearing loss? No effects of recreational noise exposure on ABR wave-I amplitude in humans. Frontiers in Neuroscience,11:465.

Fulbright, A., Le Prell, C.G., Griffiths, S., and Lobarinas, E. (2017, in press). Effects of recreational noise on threshold and supra-threshold measures of auditory function, Seminars in Hearing, doi: 10.1055/s-0037-1606325 [Epub ahead of print].

Spankovich, C., Le Prell, C.G., Lobarinas, E., and Hood, L. (2017, in press). Noise history and auditory function in young adults with type-I diabetes? Ear and Hearing, doi; 10.1097/AUD.0000000000000457 [Epub ahead of print].

These three papers are part of a special issue on Noise-Induced Hearing Loss and the military, with the special issue sponsored by the DoD Hearing Center of Excellence.

Le Prell, C.G., and Clavier, O. (2017). Effects of noise on speech recognition: Challenges for Communication by service members. Hearing Research, 349: 76-89.

Lobarinas, E., Spankovich, C., and Le Prell, C.G. (2017). Evidence of “hidden hearing loss” following noise exposures that produce robust TTS and ABR wave-I amplitude reductions. Hearing Research, 349: 155-163.

Kobel, M., Le Prell, C.G., Hawks, J. W., Liu, J., and Bao, J. (2017). Critical preclinical and clinical issues of cochlear synaptopathy. Hearing Research, 349: 148-154.

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