Hyuntae Yoo, PhD
Education and Professional Affiliations
- Postdoctoral Training - Institute for Systems Biology (Leroy Hood group)
- PhD - Massachusetts Institute of Technology (Biological Chemistry)
- BS - Seoul National University (Chemistry)
Overview: Application of Systems Biology approaches to Human Diseases
Discovery of new drug targets for a variety of human diseases is one of the most pressing issues in biomedical research. The research efforts thus far have made significant progresses for therapeutic application to a larger number of patients than ever before. A major challenge to expanding these advances to general pool of patients is that patients show a wide range of global molecular differences arising from both genetic and environmental variations, which makes it almost impossible to apply one set of therapeutic measures to all patients. I propose to address this problem by applying a unique set of systems biology approaches to experimental models of human diseases. My lab’s approach will be based on comprehensive functional integration of genomic, proteomic, and metabolomic datasets from well-established experimental disease models using global scale high-throughput techniques such as DNA microarray and mass spectrometry-based proteomics/metabolomics. This integrative approach will allow us to identify unique sets of functionally important genes, proteins, and metabolites involved in disease processes uniquely associated with particular subgroups of individual patients and to reveal corresponding pathways and specific molecules that are strong candidates for novel therapeutic intervention.
- As leading author:
- Daehee Hwang*, Inyoul Y. Lee*, Hyuntae Yoo*, Nils Gehlenborg, Ji-Hoon Cho, Brianne Petritis, David Baxter, Rose Pitstick, Rebecca Young, Doug Spicer, John Hohmann, Stephen J. DeArmond, George A. Carlson, Leroy E. Hood (2009) A Systems Approach to Prion Disease. Molecular Systems Biology 5:252.
- Hyuntae Yoo*, Maciek R. Antoniewicz*, Gregory Stephanopoulos and Joanne K. Kelleher (2008) Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. Journal of Biological Chemistry, 283(30):20621-7.
- Hyuntae Yoo, Gregory Stephanopoulos and Joanne K. Kelleher (2004) Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes. Journal of Lipid Research, 45:1324-1332.
* indicates equal contribution to first authorship
- As secondary author:
- Nils Gehlenborg*, Daehee Hwang*, Inyoul Y. Lee*, Hyuntae Yoo, David Baxter, Brianne Petritis, Rose Pitstick, Bruz Marzolf, Stephen J. DeArmond, George A. Carlson, Leroy Hood (2009) The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (0):bap011.
- Nils Gehlenborg, Wei Yan, Inyoul Y. Lee, Hyuntae Yoo, Kay Nieselt, Daehee Hwang, Ruedi Aebersold and Leroy Hood (2009) Prequips - An Extensible Software Platform for Integration, Visualization and Analysis of LC-MS/MS Proteomics Data. Bioinformatics 25(5):682-3.
- Nathan D. Price, Lucas B. Edelman, Inyoul Lee, Hyuntae Yoo, Daehee Hwang, George Carlson, David J. Galas, James R. Heath, Leroy Hood (2008) “Systems Biology and Systems Medicine” in Genomic and Personalized Medicine: From Principles to Practice (ed. Ginsburg, G. and Willard, H.), Elsevier:New York, pp74-85.
- Jamey D. Young, Jason L. Walther, Maciek R. Antoniewicz, Hyuntae Yoo, and Gregory Stephanopoulos (2008) An Elementary Metabolite Unit (EMU) Based Method of Isotopically Nonstationary Flux Analysis. Biotechnology and Bioengineering, 99:686.
- B. Moon Kim, Sung Jin Bae, Soon Mog So, Hyun Tae Yoo, Sun Ki Chang, Jung Hwan Lee, and JaeSung Kang (2001) Synthesis of a Chiral Aziridine Derivative as a Versatile Intermediate for HIV Protease Inhibitors. Organic Letters, 3(15):2349-2351.
- Updated: February 18, 2011