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Physics Colloquium: Hyperpolarized Carbon-13 and Magnetic Resonance Enables Real Time Estimates of Metabolic Flux
Wednesday, Mar 11, 2015
4 p.m. - 5:15 p.m. Location: SLC 1.102

Dr. Matthew Merritt (UT Southwestern)

The advent of a straightforward method for producing hyperpolarized Carbon-13-labeled metabolic substrates is extending the reach of MRI into metabolic imaging. Fundamental metabolic processes in the heart and liver can now be studied in functioning tissues and in vivo with a time resolution that is unprecedented. Glucose utilization and tricarboxylic acid (TCA) cycle turnover are both intricately linked to energy homeostasis in living systems. Using either hyperpolarized pyruvate or dihydroxyacetone (DHA), individual enzyme catalyzed steps of these reaction pathways can be elucidated in detail. In this presentation, the relationship of [Carbon-13]bicarbonate production from hyperpolarized [1-Carbon-13]pyruvate will be explored as a possible metric of glucose production in the liver. Alternatively, DHA will be shown as a perhaps more attractive alternative for studying glucose production, as hyperpolarized glucose derived from DHA can be directly detected. Interpretation of these results is subject to a complete understanding of the magnetic resonance phenomena that control the appearance of the time activity curves of the hyperpolarized species. 

Contact Info:
Michael Kesden, 972-883-3598
Questions? Email me.

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