4 p.m. - 5:15 p.m. Location: SLC 1.102
Dr. Hana Dobrovolny (TCU)
Severe, long-lasting influenza infections are often caused by new strains of influenza. The long duration of these infections leads to an increased opportunity for the emergence of drug resistant mutants. This is particularly problematic for new strains of influenza since there is often no vaccine, so drug treatment is the first line of defense. One strategy for trying to minimize drug resistance is to apply periodic treatment. During treatment the wild-type virus decreases, but resistant virus might increase; when there is no treatment, wild-type virus will hopefully out-compete the resistant virus, driving down the number of resistant virus. This talk will discuss a mathematical model of severe influenza, a model of drug resistance and a combined model that can be used to study emergence of drug resistance during a long-lasting infection. The model predicts that cell regeneration rate is a key parameter for the success of periodic treatment.