BSB 11.538 (Research)
BE 3.312 (Teaching)
Jung-Mo Ahn , Ph.D.
Bio-Organic and Medicinal Chemistry
B.S., Seoul National University (1992)
M.S., Seoul National University (1994)
Ph.D., University of Arizona (2000)
Postdoctoral Associate, The Scripps Research Institute (2001–04)
The central theme of my research is to understand the chemistry and biology of peptides and proteins and to develop new approaches for manipulating these properties with purposefully designed small organic molecules. We employ chemical synthesis and combinatorial chemistry as well as spectroscopic and biophysical methods to accomplish these aims. Projects include:
- Rational design of small organic molecules for mimicking protein secondary structures
- Inhibition of key protein-protein interactions in various cancer models
"Facile synthesis of benzamides to mimic an α-helix." Ahn, J.-M., Han, S.-Y. Tetrahedron Lett. (2007) 48: 3543-3547.
"Novel Amphiphilic Alpha-Helix Mimetics Based on a Bis-Benzamide Scaffold." Marimganti, S., Cheemala, M.N., Ahn, J.-M., Org. Lett. (2009) 11:4418-4421.
"Development of potent GLP-1 agonists with high enzyme stability by introducing multiple lactam bridges." Murage, E.N., Gao, G., Bisello, A., Ahn, J.-M., J. Med. Chem. (2010) 53:6412-6420.
"Solid-phase synthesis of tris-benzamides as alpha-helix mimetics." Lee, T.-K., Ahn, J.-M., ACS Comb. Sci. (2011) 13:107-111.
"Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer." Ravindranathan, P., Lee, T.-K., Yang, L., Centenera, M.M., Butler, L., Tilley, W.D., Hsieh, J.-T., Ahn, J.-M., Raj, G.V. Nature Communications (2013) 4:1923, doi:10.1038/ncomms2912.
"Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications." Manandhar, B., Ahn, J.-M., J. Med. Chem. (2015) 58: 1020-1037. doi: 10.1021/jm500810s.
- Updated: January 18, 2017