A. Dean Sherry, PhD
Cecil H. and Ida Green Distinguished Chair in Systems Biology, Professor of Chemistry
Director, Advanced Imaging Research Center, UT Southwestern
MRI contrast agents; biomedical NMR
B.S., Wisconsin State University (1967): Chemistry
PhD, Kansas State University (1971): Physical/Inorganic Chemistry
NIH Postdoctoral Associate, New Mexico State University (1971–72)
Department of Radiology, UT Southwestern; Director
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas
Our chemistry group at UT Dallas is involved in the design of novel MR imaging agents that respond to physiology and metabolism, including targeted Gd3+-based agents that respond to binding events in vivo and paramagnetic CEST agents that offer multi-color imaging of metabolic events and that can be turned off and on by application of a radiofrequency pulse.
Other active areas of research include biomedical magnetic resonance techniques, applications of 13C and 2H NMR to studies of intermediary metabolism in animals and humans, in vivo spectroscopy in human tissues.
“Flux Through Hepatic Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase Detected by Hyperpolarized 13C Magnetic Resonance”, ME Matthew , Harrison C, AD Sherry, CR Malloy SC Burgess, Proc. Natl. Acad. Sci. USA, 108, 19084-9 (2011).
“Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent”, AJ Lubag, LM De Leon-Rodriguez, SC Burgess, &AD Sherry, Proc. Natl. Acad. Sci. USA, 108, 18400-18405 (2011).
“Imaging the Extracellular pH of Tumors by MRI after Injection of a Single Cocktail of T1 and T2 Contrast Agents”, GV Martinez, X Zhang, ML García-Martín, DL Morse, M Woods, AD Sherry & RJ Gillies, NMR in Biomed., 24, 1380-1391 (2011).
“Europium(III) DOTA-tetraamide Complexes as Redox Active MRI Sensors”, J Ratnakar, S Viswanathan, Z Kovács, K Green, A Jindal & AD Sherry, J Amer Chem Soc, 134, 5798-5800 (2012).
“PET and MR Agents for Molecular Imaging of Cancer Metabolism”, Y Wu, X Sun & AD Sherry, in Principles of Molecular Diagnostics and Personalized Cancer Medicine, edited by Dongfeng Tan, MD, and Henry Lynch, MD, Lippincott, Williams & Wilkins, 2012.
- Updated: July 24, 2013