A. Dean Sherry, PhD

A. Dean Sherry, Ph.D.


Contact Information

Email: [email protected]

[email protected]


A. Dean Sherry, PhD

Professor of Chemistry

Biographical Sketch

Cecil and Ida Green Distinguished Chair in Systems Bioscience
Professor of Chemistry
Director, Advanced Imaging Research Center, UT-Southwestern
Professor of Radiology, UT-Southwestern


B. Sc., Chemistry, Wisconsin State University, LaCrosse, 1967
Ph. D., Inorganic Chemistry, Kansas State University, 1971

Fields of Research Specialization

Biomedical magnetic resonance techniques, applications of 13C & 2H NMR to study intermediary metabolism, lanthanide based MRI contrast agents, biologically responsive imaging agents and lanthanide-macrocyclic complexes.

Employment History

1971-1972       NIH Postdoctoral Fellow, New Mexico State University
1972-1976       Assistant Professor, University of Texas at Dallas
1975-1980       Visiting Staff Member, Los Alamos Scientific Laboratories
1974-1982       Adjunct Professor of Biochemistry & Biophysics, UT Southwestern Medical Center
1976-1982       Associate Professor, University of Texas at Dallas
1979-1990       Head, Programs in Chemistry, University of Texas at Dallas
1982-pres.       Professor of Chemistry, University of Texas at Dallas
1983-1984       NIH Senior Fellow, UT Southwestern Medical Center, Dallas
1991-pres.       Professor of Radiology, UT Southwestern Medical Center, Dallas
1997                Scientific Founder, Macrocyclics, Inc.
2002-2005       Cecil & Ida Green Honors Chair in Chemistry, University of Texas at Dallas
2005-pres        Associate Editor, Contrast Media & Molecular Imaging, John Wiley
2005-pres        Distinguished Chair in Systems Biology, University of Texas at Dallas
2005-pres        Director, Advanced Imaging Research Center, UT Southwestern Medical Center
2010-11           Secretary, Society for Molecular Imaging (SMI)
2010-pres        Deputy Editor, Magnetic Resonance in Medicine
2011                Co-Chair, Imaging in 2020
2012                Co-Chair, Metals in Medicine Gordon Research Conference

Awards, Fellowships and Current Memberships

  • NSF Research Trainee, 1970-1971, Kansas State University
  • NIH Postdoctoral Fellow, 1971-1972, New Mexico State University
  • AWU-AEC Summer Faculty Fellowship, 1975, Los Alamos Scientific Lab.
  • NIH Senior Fellow, 1983-1984, University of Texas Southwestern Medical Center, Dallas
  • W.T. Doherty Award, 1990, DFW Section of the American Chemical Society
  • UT Dallas Chancellor's Council Outstanding Teaching Award, 1994
  • American Chemical Society, Phi Kappa Phi, Phi Lambda Upsilon
  • Biophysical Chemistry (BBCB) Study Section Member, 1999-2003
  • Scientific Founder, Macrocyclics, Inc.
  • Elected Fellow of the International Society for Magnetic Resonance in Medicine, 2011
  • Secretary, Society for Molecular Imaging (SMI), 2010-11
  • Deputy Editor, Magnetic Resonance in Medicine, 2010-pres
  • Co-Chair, Imaging in 2020, 2011
  • Co-Chair, Metals in Medicine Gordon Research Conference, 2012
  • 2011 Fellow, International Society for Magnetic Resonance in Medicine (ISMRM)
  • 2013 Gold Medal Award, World Molecular Imaging Society (WMIS)

Recent Publication Highlights

Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups”, A Pasha, M Lin, G Tircso, M Woods, GE Kiefer, AD Sherry & X Sun, J. Biol. Inorg. Chem., 14, 421-438 (2009).

“Orientation of Lipid Strands in the Extracellular Compartment of Muscle: Effect on Quantitation of Intramyocellular Lipids” A Khuu, J Ren, I Dimitrov, DE Woessner, J Murdoch, AD Sherry & CR Malloy, Magn. Reson. Med., 61, 16-21 (2009).
“In vivo Off-Resonance Saturation Magnetic Resonance Imaging of avb3-Targeted Superparamagnetic Nanoparticles”, C Khemtong, CW Kessinger, J Ren, EA Bey, S-G Yang, JS Guthi, DA Boothman, AD Sherry & J Gao, Cancer Res., 69, 1651-1658 (2009).
“Evidence for reverse flux through pyruvate kinase in skeletal muscle”, ES Jin, AD Sherry & CR Malloy, Amer. J. Physiol., 296, E748-E757 (2009).
“Comprehensive metabolic analysis for understanding of disease mechanisms” CB Newgard, RD Stevens, BR Wenner, SC Burgess, O Ilkayeva, MJ Muehlbauer, AD Sherry & JR Bain, Genomic and Personalized Medicine, 1, 180-192 (2009).
“(S)-5-(p-nitrobenzyl)-PCTA, a Promising Bifunctional Ligand with Advantageous Metal Ion Complexation Kinetics”, G Tircso, E Tircsone-Benyo, EH Suh, P Jurek, GE Kiefer, AD Sherry & Z Kovacs, Bioconjugate Chemistry, 20, 565-575 (2009).  
“A New Gadolinium-based MRI Zinc Sensor”, AC Esqueda, JA López, G Andreu-de-Riquer, JC Alvarado-Monzón, J Ratnakar, AJM Lubag, AD Sherry & LM De León-Rodríguez, J. Amer. Chem. Soc., 131, 11387-11391 (2009).

“Modulation of Water Exchange in EuDOTA-tetraamide Complexes: Considerations for in vivo Imaging of PARACEST Agents”, T Mani, G Tircsó, O Togao, P Zhao, T Soesbe, M Takahashi & AD Sherry, Contrast Media & Mol Imaging, 4, 183-191 (2009).
“Responsive MRI agents for sensing metabolism in vivoLM De Leon-Rodriguez, AJM Lubag, CR Malloy, GV Martinez, RJ Gillies & AD Sherry, Accts. Chem. Res., 42, 948-957 (2009).
“A primer on gadolinium chemistry”, AD Sherry, P Caravan & RE Lenkinski, J. Magn. Reson. Imag., 30, 1240-1248 (2009).
“NMR Characterization of Lanthanide(III) Complexes of Tetraazatetrakisphosphinato and tetraazatetrakisphophonato Ligands”, GA Pereira, L Ball, AD Sherry, JA Peters and CFGC Geraldes, Helv. Chim. Acta, 92, 2532-2551 (2009).
“The Effect of the Regiochemistry of Butyl Amide Substituents on the Solution-State Structures of Lanthanide(III) DOTA-tetraamide complexes”, T Mani, M Woods, P Zhao, G Tircsó & AD Sherry, Inorg. Chem., 48, 10338-10345 (2009).

“Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents”,  SE Plush, M Woods, Y Zhou, SB Kadali & MS Wong, J. Amer. Chem. Soc., 131, 15918-15923 (2009).

“Lanthanide(III) complexes of tris(amide)-PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents”, FA Rojas-Quijano, ET Benyó, G Tircsó, FK Kálmán, Z Baranyai, S Aime, AD Sherry & Z Kovács, Chem. Eur. J., 15, 13188-13200 (2009).
“Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands”, S Viswanathan, SJ Ratnakar, KN Green, Z Kovacs, LM De León & AD Sherry, Angew. Chem. Int. Ed., 48, 9330-9333 (2009).

“A Multislice Gradient Echo Pulse Sequence for CEST Imaging”, WT Dixon, I Hancu, SJ Ratnaker, AD Sherry, RE Lenkinski & DC Alsop, Magn. Reson. Med., 63, 253–256 (2010).   

“Hyperpolarized 89Y Complexes as pH Sensitive NMR Probes”, AK Jindal, ME Merritt, EH Suh, CR Malloy, AD Sherry & Z Kovacs, J. Amer. Chem. Soc., 132, 1784-1785 (2010).  

“A Concentration-Independent Method to Measure Exchange Rates in PARACEST Agents”, WT Dixon, J Ren, AJM Lubag, J Ratnakar, E Vinogradov, I Hancu, RE Lenkinski & AD Sherry, Magn. Reson. Med., 63, 625-632 (2010).  

“Advantages of Macromolecular to Nanosized Chemical-exchange Saturation Transfer Agents for MRI Applications”, Y Wu, M  Evbuomwan, M Melendez, A Opina & AD Sherry, Future Medicinal Chemistry, 2, 351-366 (2010).     

“Bimodal MR-PET Agent for Quantitative pH Imaging”, L Frullano, C Catana, T Benner, AD Sherry & P Caravan, Angew. Chem. Int. Ed., 49, 2382-2384 (2010).      

“Competition of Pyruvate with Physiological Substrates for Oxidation by the Heart:  Implications for Studies with Hyperpolarized [1-13C]Pyruvate”, KX Moreno, SM Sabelhaus, ME Merritt, AD Sherry & CR Malloy, Amer. J. Physiol., 298, H1556-H1564 (2010).  

 “Alternatives to Gadolinium-based MRI Metal Chelates for Magnetic Resonance Imaging”, S. Viswanathan, Z. Kovacs, SJ Ratnakar, KN Green & AD Sherry, Chem. Rev., 110, 2960-3018 (2010).  

 “Improved Synthesis of DOTA-Tetraamide Ligands for Lanthanide(III) ions: A Tool for Increasing the Repertoire of Potential PARACEST Contrast Agents for MRI and/or Fluorescent Sensors”, LM DeLeon-Rodriguez, S Viswanathan & AD Sherry, Contrast Media & Mol. Imaging, 5, 121-125 (2010).  

“Activation of a PARACEST Agent for MRI through Selective Outer-sphere Interactions with Phosphate Diesters”, C-H Huang, J Hammell, SJ Ratnakar, AD Sherry & JR Morrow, Inorg. Chem., 49, 5963-5970 (2010).  

“CEST and PARACEST MR Contrast Agents”, I Hancu, WT Dixon, M Woods, E Vinogradov, AD Sherry & RE Lenkinski, Acta Radiologica, 51, 910-923 (2010).  

"Multifunctional Polymeric Scaffolds for Enhancement of PARACEST Contrast Sensitivity and Performance: The Effects of Random Copolymer Variations" Y Wu, P Zhao, G Kiefer & AD Sherry, Macromolecules, 43, 6616-6624 (2010).   
 “The Population of SAP and TSAP Isomers in Cyclen-Based Lanthanide(III) Chelates is Substantially Affected by Solvent”, KJ Miller, AA Saherwala, B Webber, Y Wu, AD Sherry & M Woods, Inorg. Chem., 49, 8662-8664 (2010).  

“Polymeric PARACEST MRI Contrast Agents as Potential Reporters for Gene Therapy”, Y Wu, C Carney, M Denton, E Hart, P Zhao, DN Streblow, AD Sherry & M Woods, Org. Biomol. Chem., 8, 5333-5338 (2010).   
“A Responsive Europium(III) Chelate that Provides a Direct Readout of pH by MRI”, Y Wu, TC Soesbe, GE Kiefer, P Zhao & AD Sherry, J. Amer. Chem. Soc., 132, 14002-14003 (2010).  

“1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression”, J Ren, AD Sherry & CR Malloy, Magn. Reson. Med., 64, 662-671 (2010).  
 “MRI Detection of VEGFR2 in vivo Using a Low Molecular Weight Peptoid-(Gd)8-Dendron for Targeting”, LM DeLeon-Rodriquez, A Lubag, DG Udugamasooriya, B Proneth, RA Brekken, X Sun, T Kodadek & AD Sherry, J. Amer. Chem. Soc., 132, 12829-12831 (2010).  

“Strategies for Labeling Proteins with PARACEST Agents”, O Vasalatiy, P Zhao, M Woods, A Marconescu , A Castillo-Muzquiz, P Thorpe, GE Kiefer & AD Sherry, Bioorg & Med. Chem., 19, 1106-1114 (2011).  

“The Effect of 13C Enrichment in the Glassing Matrix on Dynamic nuclear Polarization of [1-13C]pyruvate”, L Lumata, Z Kovacs, CR Malloy, AD Sherry & ME Merritt, Phys Med. Biol.,  56: N85-N92 (2011).   

“Europium(III) DOTA-derivatives having Ketone Donor Pendant Arms Display Dramatically Slower Water Exchange”, KN Green, S Viswanathan, FA Rojas-Quijano, Z Kovacs & AD Sherry, Inorg. Chem., 50, 1648-1655 (2011).  

“A Lanthanide Complex with Dual Biosensing Properties: CEST (Chemical Exchange Saturation Transfer) and BIRDS (Biosensor Imaging of Redundant Deviation in Shifts) with Europium DOTA-Tetraglycinate-“, D Coman, GE Kiefer, DL Rothman, AD Sherry & F Hyder, NMR in Biomed., 24, 1216-1225 (2011).  
"Off-Resonance Saturation MRI of Superparamagnetic Nanoprobes: Theoretical Models and Experimental Validations"  C Khemtong, O Togao, J Ren, C Kessinger, M Takahashi, AD Sherry & J Gao, J. Magn. Reson., 209, 53–60 (2011).  

“Investigations into Whole Water, Prototropic and Amide Proton Exchange in Lanthanide(III) DOTA-Tetraamide Chelates”, M Woods, A Pasha, G Tircso, S Chowdhury, G Kiefer, DE Woessner and AD Sherry, Dalton Trans., 40, 6759-6764 (2011).  

DNP by Thermal Mixing under Optimized Conditions Yields >60 000-fold Enhancement of (89)Y NMR Signal” LL Lumata, AK Jindal, ME Merritt, CR Malloy, AD Sherry & Z Kovacs, J. Amer. Chem. Soc., 133, 8673-8680 (2011).  

“On-Bead Combinatorial Synthesis and Imaging of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Agents To Identify Factors That Influence Water Exchange”, R Napolitano, TC Soesbe, L DeLeon-Rodriguez, AD Sherry, & D. Gomika Udugamasooriya, J. Amer. Chem. Soc., 133, 13023-13030 (2011).  

“BDPA:  An Efficient Polarizing Agent for Fast Dissolution Dynamic Nuclear Polarization NMR Spectroscopy” LL Lumata, SJ Ratnakar, AK Jindal, ME Merritt, A Comment, CR Malloy, AD Sherry & Z Kovacs, Chem. Eur. J., 17, 10825-10827 (2011).  

 “Could 13C MRI Assist Clinical Decision-Making for Patients with Heart Disease?” CR Malloy, ME Merritt & AD Sherry, NMR in Biomed., 24, 973-979 (2011).   

“T2 Exchange Agents: A New Class of Paramagnetic MRI Contrast Agent that Shortens Water T2 by Chemical Exchange Rather than Relaxation”, TC Soesbe, ME Merritt, KN Green, FA Rojas-Quijano & AD Sherry, Magn. Reson. Med., 66, 1697-1703 (2011).  

“Flux Through Hepatic Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase Detected by Hyperpolarized 13C Magnetic Resonance”,  ME Matthew , Harrison C, AD Sherry, CR Malloy SC Burgess, Proc. Natl. Acad. Sci. USA, 108, 19084-9 (2011).   
 “The pH Sensitivity of –NH Exchange in LnDOTA-tetraamide Complexes Varies with Amide Substituent”, ACL Opina, Y Wu, P Zhao, GE Kiefer & AD Sherry, Contrast Media Mol Imaging, 6: 459-64 (2011).  
“Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent”,  AJ Lubag,  LM De Leon-Rodriguez, SC Burgess, &AD Sherry, Proc. Natl. Acad. Sci. USA,  108, 18400-18405 (2011).  

“TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive lipoCEST agents”, ACL Opina, KB Ghaghada, P Zhao, GE Kiefer, A Annapragada & AD Sherry, PLoS One 6:  e27370. (2011).   

“Transfer of Hyperpolarization from Long T1 Storage Nuclei to Short T1 Neighbors Using FLOPSY-8”, K Moreno, C Harrison, AD Sherry, CR Malloy & ME Merritt, J. Magn. Reson., 213, 187-191 (2011).   

 “Towards the Rational Design of MRI Contrast Agents: d-Substitution of Lanthanide(III) NB-DOTA-Tetraamide Chelates Influences but Does Not Control Coordination Geometry”, CE Carney, AD Tran, J Wang, MC Schabel, AD Sherry & M Woods, Chem. Eur. J., 17, 10372-10378 (2011).  

 “Imaging the Extracellular pH of Tumors by MRI after Injection of a Single Cocktail of T1 and T2 Contrast Agents”, GV Martinez, X Zhang, ML García-Martín, DL Morse, M Woods, AD Sherry & RJ Gillies, NMR in Biomed., 24, 1380-1391 (2011).

“In Vivo Determination of Human Breast Fat Composition by 1H Magnetic Resonance Spectroscopy at 7T”. IE Dimitrov, D Douglas D, J Ren, NB Smith, AG Webb, AD Sherry, & Malloy CR,  Magn Reson Med., 67:20-26 (2012).  

“Using frequency-labeled exchange (FLEX) transfer to separate out conventional magnetization transfer effects from exchange transfer effects when detecting PARACEST agents”, C-Y Lin, NN Yadav, JI Friedman, J Ratnakar, AD Sherry, PCM van Zijl, Magn Reson Med, 67, 906-911 (2012).

“SWIFT-CEST:  A New Method to Overcome T2 Shortening Caused by PARACEST Contrast Agents”, TC Soesbe, O Togao, M Takahashi & AD Sherry, Magn. Reson. Med., 68, 816-821 (2012).

 “Nanoparticle-based PARACEST agents: The quenching effect of silica nanoparticles on the CEST signal from surface conjugated chelates”, OM Evbuomwan, ME Merritt, GE Kiefer & AD Sherry, Contrast Media & Mol. Imaging, 7, 19-25 (2012).

“Amphiphilic EuDOTA-tetraamide complexes form micelles with enhanced CEST sensitivity”, OM Evbuomwan, GE Kiefer & AD Sherry, J. Biol. Inorg. Chem., 2012, 2126-2134.

"Synthesis and Characterization of a Hypoxia-Sensitive MRI Probe", F Rojas-Quijano, G Tircso, E Tircsone Benyo, Z Baranyai, H Hoang, F Kalman, P Gulaka, V Kodibagkar, S Aime, Z Kovács, AD Sherry, Chem Eur J, 18, 9669-9676 (2012).

“Europium(III) DOTA-tetraamide Complexes as Redox Active MRI Sensors”,  J Ratnakar, S Viswanathan, Z Kovács, K Green, A Jindal & AD Sherry, J Amer Chem Soc, 134, 5798-5800 (2012).

“A second generation MRI contrast agent for imaging zinc ions in vivo”, LM De León-Rodríguez, AJM Lubag, JA López, G Andreu-de-Riquer, JC Alvarado-Monzón & AD Sherry, Med Chem Commun, 3, 480-483 (2012).

“Fast dissolution dynamic nuclear polarization NMR of 13C-enriched 89Y-DOTA complex:  Experimental and theoretical considerations”, L Lumata, ME Merritt, CR Malloy, AD Sherry & Z Kovacs, Appl. Magn. Reson., 43, 69-79 (2012).

"Impact of Gd3+ on DNP of [1-13C]Pyruvate Doped with Trityl OX063, BDPA, or 4-oxo-TEMPO", L Lumata, ME Merritt, CR Malloy, AD Sherry & Z Kovács, J. Phys. Chem. A, 116, 5129-5138 (2012).

“PET and MR Agents for Molecular Imaging of Cancer Metabolism”, Y Wu, X Sun & AD Sherry, in Principles of Molecular Diagnostics and Personalized Cancer Medicine, edited by Dongfeng Tan, MD, and Henry Lynch, MD, Lippincott, Williams & Wilkins, 2012.

 “Imaging free zinc levels in vivo – what can be learned?”, L DeLeon-Rodriquez, AJM Lubag & AD Sherry, Inorganica Chemica Acta, http://dx.doi.org/http://dx.doi.org/10.1016/j.ica.2012.06.026.

 “Dynamic Monitoring of Carnitine and Acetylcarnitine in the Trimethylamine Signal after Exercise in Human Skeletal Muscle by 7T 1H MRS, J Ren, S Lakoski, RG Haller, AD Sherry & CR Malloy, Magn Reson Med, 69, 7-17 (2013).

“CEST and PARACEST agents for molecular imaging”, OM Evbuomwan, AD Sherry, S Aime & E Terreno in “The Chemistry of Molecular Imaging”, Edited by Nicholas J. Long, Wing-Tak Wong & Edmund H. Immergut,  J. Wiley & Sons, October 2013.

“13C NMR for Analysis of Metabolic Pathways”, CR Malloy, E Maher, I Marin-Valencia, B Mickey, RJ DeBerardinis & AD Sherry, in “Methodologies for Metabolomics”, edited by NW Lutz, JV Sweedler, RA Wevers, Cambridge University Press, 2013, pp. 415-445.

 “Stability and Toxicity of Contrast Agents”, E Brücher, G Tircsó, Z Baranyai, Z Kovács & AD Sherry (2013) in “Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging” 2nd Edition, edited by AE Merbach, E Toth and L Helm, Chapter 5, pp. 157-208, John Wiley & Sons, NY.

“Advantages of paramagnetic CEST complexes having slow-to-intermediate water exchange properties as responsive MRI agents”, TC Soesbe, Y Wu & AD Sherry, NMR Biomed, 26, 829-838 (2013).

“The importance of water exchange rates in the design of responsive agents for MRI”, AD Sherry & Y Wu, Curr. Opin. Chem. Biol., 288, 2914-2922 (2013).

“Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP”, L Lumata, Z Kovacs, AD Sherry, CR Malloy, S Hill, J van Tol, L Yu, L Song & ME Merritt, Physical Chemistry Chemical Physics, 15, 9800-9807 (2013).

“CEST: From basic principles to application, challenges and opportunities”, E Vinogradov, AD Sherry & RE Lenkinski, J. Magn. Reson., 229, 155-172 (2013).

"Evidence for Transaldolase Activity in the Isolated Heart Supplied with [U-13C3]glycerol", ES Jin, AD Sherry & CR Malloy, J. Biol. Chem., 288, 2914-2922 (2013).

“Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent”, LL Lumata, ME Merritt, CR Malloy, AD Sherry, J van Tol, L Song & Z Kovacs, J. Magn. Reson., 227, 14-19 (2013).

“Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical Shift Barcodes”, X Huang, G Huang, S Zhang, K Sagiyama, O Togao, Y Wang, Y Li, M Takahashi, AD Sherry & J Gao, Angew Chem Int Ed., 52, 8074-8078 (2013).

“Metabolism of Glycerol, Glucose and Lactate in the Citric Acid Cycle Prior to Incorporation into Hepatic Triglycerides”, E Jin, AD Sherry & CR Malloy, J. Biol. Chem., 288, 14488-14496 (2013).

 “A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI”, B Song, Y Wu, M Yu, P Zhao, C Zhou, GE Kiefer, & AD Sherry, Dalton Trans., 2013, 8066 - 8069.

“A Novel Class of Polymeric pH-Responsive MRI CEST Agents”, S Zhang, K Zhou, M Takahashi, AD Sherry, & J Gao, Chem. Commun., 49, 6418-6420 (2013).

“Noninvasive Monitoring of Lactate Dynamics in Human Forearm Muscle after Exhaustive Exercise by 1H Magnetic Resonance Spectroscopy at 7 Tesla”, J Ren, AD Sherry & CR Malloy, Magn Reson Med, 70, 610-619 (2013).

"Characterization of lung cancer by amide proton transfer (APT) imaging: An in-vivo study in an orthotopic mouse model", PLOS one, O Togao, CW Kessinger, G Huang, TC Soesbe, K Sagiyama, I Dimitrov, AD Sherry, J Gao & M Takahashi, PLoS One 2013 Oct 15;8(10):e77019.

“Modulation of CEST Images in Vivo by T1 Relaxation: A New Approach in the Design of Responsive PARACEST Agents”, SJ Ratnakar, TC Soesbe, L Lumata, QN Do, S Viswanathan, C-Y Lin, AD Sherry & Z Kovacs, J Amer Chem Soc, 135, 14904-14907 (2013).

 “APT imaging allows early detection of therapeutic response of glioblastoma to chemotherapy”, K Sagiyama, T Mashimo, O Togao, V Vemireddy, KJ Hatanpaa, MA Maddie, EA Maher, AD Sherry, RM Bachoo, & M Takahashi, PNAS, in press.

“The stereochemistry of amide side-chains containing carboxyl groups influences water exchange rates in EuDOTA-tetraamide complexes”, T Mani, ACL Opina, P Zhao, M Evbuomwan, N Milburn, G Tircso, C Kumas & AD Sherry, J Biol Inorg Chem, 19, 161-171 (2014).

 “Activation of PDH by Propionate Results in Increased H13CO3- Production From Hyperpolarized [1-13C]Pyruvate” C Purmal, B Kucejovic, AD Sherry, SC Burgess, CR Malloy & ME Merritt, J Magn Reson, submitted.

“Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells”, C Yang, C Harrison, ES Jin, DT Chuang, AD Sherry, CR Malloy, ME Merritt & RJ DeBerardinis, J. Biol. Chem., in press.

“GdDO3NI, a nitroimidazole based T1 MR contrast agent allows in vivo non-invasive high-resolution imaging of tumor hypoxia”,  PK Gulaka, F Rojas-Quijano, Z Kovacs, RP Mason, AD Sherry & VD Kodibagkar, J Biol Inorg Chem, in press.

“Maximizing T2-exchange in DyDOTA-(amide)X chelates: Fine-tuning the water molecule exchange rate for enhanced T2 contrast in MRI”, TC Soesbe, SJ Ratnakar, M Milne, S Zhang, QN Do, Z Kovacs & AD Sherry, Magn Res Med, in press.

“Influence of Available Substrates on Pathways of 13CO2 Production from Hyperpolarized [1-13C]pyruvate in Mouse Liver”, KX Moreno, C Moore, SC Burgess, AD Sherry, CR Malloy & ME Merritt, PNAS, submitted.

“Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism”, C Khemtong, NR Carpenter, LL Lumata, ME Merritt, KX Moreno, Z Kovacs, CR Malloy & AD Sherry, Nature Commun., submitted.

“68Ga-HP-DO3A-nitroimidazole: a promising agent for PET detection of tumor hypoxia”, Y Wu, G Hao, X Sun, D Saha, D Zhao & AD Sherry, JNM, in preparation.

“Numerical Analysis of Correlations between the NMR Chemical Shifts of Hyperpolarized 89Y Complexes and their Chemical Structures”, Y Xing, AK Jindal, P Zhao, Z Kovacs & AD Sherry, in preparation.

Updated: February 18, 2014

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