Image Placeholder

This image illustrates a new class of MRI "activatable" agents called PARACEST agents that can be turned on-and-off by switching on a RF pulse.

Chemistry Projects

“Catalytic effects of apoferritin interior surface residues on water exchange in lanthanide complexes”, O Vasalatiy, P Zhao, S Zhang, S Aime & AD Sherry, Contrast Media & Mol Imaging, 1, 1-5 (2006).

“Europium(III) Macrocyclic Complexes with Alcohol Pendant Groups as Chemical Exchange Saturation Transfer (CEST) Agents” M Woods, DE Woessner, P Zhao, A Pasha, M-Y Yang, C-H Huang, O Vasalitiy, JR Morrow, AD Sherry” J. Amer. Chem. Soc. 128, 10155-10162 (2006).

“High Resolution pHe Imaging of Rat Glioma using pH-dependent relaxivity”, ML Garcia-Martin, GV Martinez, N Raghunand, AD Sherry, S Zhang &  RJ Gillies, Magn. Reson. Med., 55, 309-315 (2006).

 “Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging”, M Woods, DE Woessner & AD Sherry, Chem Soc Rev, 35, 500-511 (2006).

 “Equilibrium and Formation/Dissociation Kinetics of some Lanthanide(III)-PCTA complexes”, G Tircsó, Z Kovács, & A D Sherry, Inorg. Chem., 45, 9269-9280 (2006).

“Sensitivity Enhancement of Multidimensional NMR experiments by Paramagnetic Relaxation Effect”, S Cai, C Seu, Z Kovacs, AD Sherry & Y Chen, J. Am. Chem. Soc., 128, 13474-13478 (2006). 

“Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems”, N Nasongkla, E Bey, J Ren, H Ai, C Khemtong, JG Setti, SF Chin, AD Sherry, DA Boothman, J Gao, Nano Letters, 6, 2427-2430 (2006).

“PARACEST agents for Molecular Imaging” in Molecular & Cellular MR Imaging, Edited by J Bulte & M Modo, AD Sherry & M Woods, CRC Press, Chapter 6, pp. 101-122 (2007).

“A Bridge to Coordination Isomer Selection in Lanthanide(III) DOTA-tetraamide Complexes”, J Vipond, M Woods, P Zhao, G Tircso, Jimmy Ren, GE Kiefer, Zoltan Kovacs & AD Sherry, Inorg. Chem., 46, 2584-2595 (2007).

 “Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications”, C Adair, M Woods, P Zhao, A Pasha, PM Winter, GM Lanza, P Athey, AD Sherry, GE Kiefer, Contrast Media & Molecular Imaging  2, 55-58 (2007).

“Potentiometric and Relaxometric Properties of Gadolinium-based MRI Contrast Agent for Sensing Tissue pH”, FK Kálmán, M Woods, P Jurek, M Spiller, P Caravan, G Tircsó, R Király, E Brücher & AD Sherry, Inorg. Chem., 46, 5260-5270 (2007).

“MRI detection of Paramagnetic Chemical Exchange Effects in mice kidneys in vivo”, E. Vinogradov, H He, A Lubag, JA Balschi, AD Sherry & RE Lenkinski, Magn Reson Med., 58, 650-655 (2007). 

 “Synthesis and characterization of DOTA-(amide)4 derivatives: equilibrium and kinetic behavior of their lanthanide(III) complexes”, A Pasha, G Tircso, ET Benyo, E Brucher & AD Sherry, Eur. J. Inorg. Chem., 4340-4349 (2007). 

“Albumin-binding PARACEST Agents”, MM Ali,  M Woods, E Suh, G Tircsó, V Kodibagkar & AD Sherry, J. Biol. Inorg. Chem., 12, 855-865 (2007).

 “Modulation of Water Exchange in Europium(III) DOTA-tetraamide Complexes via Electronic Substituent Effects”, SJ Ratnakar, Mark Woods, AJM Lubag, Z Kovács & AD Sherry, J. Amer. Chem. Soc., 130, 6-7 (2008).

“Towards the Rational Design of MRI Contrast Agents: Electron spin Relaxation is Largely Unaffected by the Coordination Geometry of Gadolinium(III) DOTA-type Complexes”, A Borel, JF Bean, RB Clarkson, L Helm, L Moriggi, AD Sherry & Mark Woods, Chem. Eur. J., 14, 2658-2667 (2008).
“Labeling of Adenovirus Particles with PARACEST Agents”, O Vasalatiy, R Gerard, P Zhao, X Sun & AD Sherry, Bioconj. Chem., 19, 598-606 (2008).
“The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain”, K Hanaoka, AJM Lubag, A Castillo-Muzquiz, T Kodadek & AD Sherry, J. Magn. Reson. Imaging, 26, 608-617 (2008).
“Advances in molecular imaging of pancreatic beta cells”, M Lin, A Lubag, MJ McGuire, SY Seliounine, EN Tsyganov, PP Antich, AD Sherry, KC Brown & X Sun, Frontiers in Bioscience, 13, 4558-4575 (2008).
“Nephrogenic Systemic Fibrosis:  A Chemical and Rational Perspective”, NM Rofsky, AD Sherry and RE Lenkinski, Radiology, 247, 608-612 (2008).
“Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes”,  JM Zhao, Y Har-el, MT McMahon, J Zhou, AD Sherry, G Sgouros, JW Bulte, PCM van Zijl,   J. Amer. Chem. Soc., 130, 5178-5184 (2008).
“Synthesis and Relaxometric Studies of a Dendrimer-Based pH-Responsive MRI Contrast Agent”, MM Ali, M Woods, P Caravan, ACL Opina, M Spiller, JC Fettinger & AD Sherry, Chem. Eur. J., 14, 7250-7258 (2008).
 “Imaging the Tissue Distribution of Glucose in Liver using a PARACEST Sensor”, J Ren, S Zhang,  R Trokowski, C Storey, A Milde, CR Malloy & AD Sherry, Magn. Reson. Med., 60, 1047-1055 (2008).
“Chemical Exchange Saturation Transfer Contrast Agents for Magnetic Resonance Imaging”. AD Sherry & M Woods, Ann. Rev. Biomed. Eng., 10, 391-411 (2008).

“The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives”, P Caravan, CFGC Geraldes, MT Greenfield, GE Kiefer, M Lin, K McMillan, MIM Prata, AC Santos, AD Sherry, X Sun, J Wang, M Woods, S Zhang & P Zhao, Invest. Radiol., 43, 861-870 (2008).

“Polymeric PARACEST Agents for Enhancing MRI Contrast Sensitivity”, Y Wu, Y Zhou, O Ouari, M Woods, P Zhao, TC Soesbe, GE Kiefer & AD Sherry, J. Amer. Chem. Soc., 130, 13854-13855 (2008).
Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups”, A Pasha, M Lin, G Tircso, M Woods, GE Kiefer, AD Sherry & X Sun, J. Biol. Inorg. Chem., 14, 421-438 (2009).

“A New Gadolinium-based MRI Zinc Sensor”, AC Esqueda, JA López, G Andreu-de-Riquer, JC Alvarado-Monzón, J Ratnakar, AJM Lubag, AD Sherry & LM De León-Rodríguez, J. Amer. Chem. Soc., 131, 11387-11391 (2009).

“Modulation of Water Exchange in EuDOTA-tetraamide Complexes: Considerations for in vivo Imaging of PARACEST Agents”, T Mani, G Tircsó, O Togao, P Zhao, T Soesbe, M Takahashi & AD Sherry, Contrast Media & Mol Imaging, 4, 183-191 (2009).

“Responsive MRI agents for sensing metabolism in vivoLM De Leon-Rodriguez, AJM Lubag, CR Malloy, GV Martinez, RJ Gillies & AD Sherry, Accts. Chem. Res., 42, 948-957 (2009).
“A primer on gadolinium chemistry”, AD Sherry, P Caravan & RE Lenkinski, J. Magn. Reson. Imag., 30, 1240-1248 (2009).
“The Effect of the Regiochemistry of Butyl Amide Substituents on the Solution-State Structures of Lanthanide(III) DOTA-tetraamide complexes”, T Mani, M Woods, P Zhao, G Tircsó & AD Sherry, Inorg. Chem., 48, 10338-10345 (2009).
“Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents”,  SE Plush, M Woods, Y Zhou, SB Kadali & MS Wong, J. Amer. Chem. Soc., 131, 15918-15923 (2009).

“Lanthanide(III) complexes of tris(amide)-PCTA derivatives as potential bimodal magnetic resonance and optical imaging agents”, FA Rojas-Quijano, ET Benyó, G Tircsó, FK Kálmán, Z Baranyai, S Aime, AD Sherry & Z Kovács, Chem. Eur. J., 15, 13188-13200 (2009).
“Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands”, S Viswanathan, SJ Ratnakar, KN Green, Z Kovacs, LM De León & AD Sherry, Angew. Chem. Int. Ed., 48, 9330-9333 (2009).
“A Multislice Gradient Echo Pulse Sequence for CEST Imaging”, WT Dixon, I Hancu, SJ Ratnaker, AD Sherry, RE Lenkinski & DC Alsop, Magn. Reson. Med., 63, 253–256 (2010).
"A Concentration-Independent Method to Measure Exchange Rates in PARACEST Agents", WT Dixon, J Ren, AJM Lubag, J Ratnakar, E Vinogradov, I Hancu, RE Lenkinski & AD Sherry, Magn. Reson. Med., 63, 625-632 (2010).

“Advantages of Macromolecular to Nanosized Chemical-exchange Saturation Transfer Agents for MRI Applications”, Y Wu, M  Evbuomwan, M Melendez, A Opina & AD Sherry, Future Medicinal Chemistry, 2, 351-366 (2010).    

 “Alternatives to Gadolinium-based MRI Metal Chelates for Magnetic Resonance Imaging”, S. Viswanathan, Z. Kovacs, SJ Ratnakar, KN Green & AD Sherry, Chem. Rev., 110, 2960-3018 (2010). 

 “Improved Synthesis of DOTA-Tetraamide Ligands for Lanthanide(III) ions: A Tool for Increasing the Repertoire of Potential PARACEST Contrast Agents for MRI and/or Fluorescent Sensors”, LM DeLeon-Rodriguez, S Viswanathan & AD Sherry, Contrast Media & Mol. Imaging, 5, 121-125 (2010).  

“Activation of a PARACEST Agent for MRI through Selective Outer-sphere Interactions with Phosphate Diesters”, C-H Huang, J Hammell, SJ Ratnakar, AD Sherry & JR Morrow, Inorg. Chem., 49, 5963-5970 (2010). 

“CEST and PARACEST MR Contrast Agents”, I Hancu, WT Dixon, M Woods, E Vinogradov, AD Sherry & RE Lenkinski, Acta Radiologica, 51, 910-923 (2010).  

"Multifunctional Polymeric Scaffolds for Enhancement of PARACEST Contrast Sensitivity and Performance: The Effects of Random Copolymer Variations" Y Wu, P Zhao, G Kiefer & AD Sherry, Macromolecules, 43, 6616-6624 (2010).  
 “The Population of SAP and TSAP Isomers in Cyclen-Based Lanthanide(III) Chelates is Substantially Affected by Solvent”, KJ Miller, AA Saherwala, B Webber, Y Wu, AD Sherry & M Woods, Inorg. Chem., 49, 8662-8664 (2010). 

“Polymeric PARACEST MRI Contrast Agents as Potential Reporters for Gene Therapy”, Y Wu, C Carney, M Denton, E Hart, P Zhao, DN Streblow, AD Sherry & M Woods, Org. Biomol. Chem., 8, 5333-5338 (2010).   

 “Strategies for Labeling Proteins with PARACEST Agents”, O Vasalatiy, P Zhao, M Woods, A Marconescu, A Castillo-Muzquiz, P Thorpe, GE Kiefer & AD Sherry, Bioorg & Med. Chem., 19, 1106-1114 (2011). 

 “Europium(III) DOTA-derivatives having Ketone Donor Pendant Arms Display Dramatically Slower Water Exchange”, KN Green, S Viswanathan, FA Rojas-Quijano, Z Kovacs & AD Sherry, Inorg. Chem., 50, 1648-1655 (2011). 

“A Lanthanide Complex with Dual Biosensing Properties: CEST (Chemical Exchange Saturation Transfer) and BIRDS (Biosensor Imaging of Redundant Deviation in Shifts) with Europium DOTA-Tetraglycinate-“, D Coman, GE Kiefer, DL Rothman, AD Sherry & F Hyder, NMR in Biomed., 24, 1216-1225 (2011). 
 “Investigations into Whole Water, Prototropic and Amide Proton Exchange in Lanthanide(III) DOTA-Tetraamide Chelates”, M Woods, A Pasha, G Tircso, S Chowdhury, G Kiefer, DE Woessner and AD Sherry, Dalton Trans., 40, 6759-6764 (2011). 

 “On-Bead Combinatorial Synthesis and Imaging of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Agents To Identify Factors That Influence Water Exchange”, R Napolitano, TC Soesbe, L DeLeon-Rodriguez, AD Sherry, & D. Gomika Udugamasooriya, J. Amer. Chem. Soc., 133, 13023-13030 (2011).  

 “The pH Sensitivity of –NH Exchange in LnDOTA-tetraamide Complexes Varies with Amide Substituent”, ACL Opina, Y Wu, P Zhao, GE Kiefer & AD Sherry, Contrast Media Mol Imaging, 6: 459-64 (2011). 

“TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive lipoCEST agents”, ACL Opina, KB Ghaghada, P Zhao, GE Kiefer, A Annapragada & AD Sherry, PLoS One 6:  e27370. (2011).  

“Towards the Rational Design of MRI Contrast Agents: ?-Substitution of Lanthanide(III) NB-DOTA-Tetraamide Chelates Influences but Does Not Control Coordination Geometry”, CE Carney, AD Tran, J Wang, MC Schabel, AD Sherry & M Woods, Chem. Eur. J., 17, 10372-10378 (2011). 

 “Nanoparticle-based PARACEST agents: The quenching effect of silica nanoparticles on the CEST signal from surface conjugated chelates”, OM Evbuomwan, ME Merritt, GE Kiefer & AD Sherry, Contrast Media & Mol. Imaging, 7, 19-25 (2012).

“Amphiphilic EuDOTA-tetraamide complexes form micelles with enhanced CEST sensitivity”, OM Evbuomwan, GE Kiefer & AD Sherry, J. Biol. Inorg. Chem., 2012, 2126-2134.

"Synthesis and Characterization of a Hypoxia-Sensitive MRI Probe", F Rojas-Quijano, G Tircso, E Tircsone Benyo, Z Baranyai, H Hoang, F Kalman, P Gulaka, V Kodibagkar, S Aime, Z Kovács, AD Sherry, Chem Eur J, 18, 9669-9676 (2012).

“Europium(III) DOTA-tetraamide Complexes as Redox Active MRI Sensors”,  J Ratnakar, S Viswanathan, Z Kovács, K Green, A Jindal & AD Sherry, J Amer Chem Soc, 134, 5798-5800 (2012).

“A second generation MRI contrast agent for imaging zinc ions in vivo”, LM De León-Rodríguez, AJM Lubag, JA López, G Andreu-de-Riquer, JC Alvarado-Monzón & AD Sherry, MedChemComm, 3, 480-483 (2012).  DOI: 10.1039/c2md00301e

 “CEST and PARACEST agents for molecular imaging”, OM Evbuomwan, AD Sherry, S Aime & E Terreno in “The Chemistry of Molecular Imaging”, Edited by Nicholas J. Long, Wing-Tak Wong & Edmund H. Immergut,  J. Wiley & Sons, October 2013.

“Stability and Toxicity of Contrast Agents”, E Brücher, G Tircsó, Z Baranyai, Z Kovács & AD Sherry (2013) in “Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging” 2nd Edition, edited by AE Merbach, E Toth and L Helm, Chapter 5, pp. 157-208, John Wiley & Sons, NY.

“Advantages of paramagnetic CEST complexes having slow-to-intermediate water exchange properties as responsive MRI agents”, TC Soesbe, Y Wu & AD Sherry, NMR Biomed, 26, 829-838 (2013).

“The importance of water exchange rates in the design of responsive agents for MRI”, AD Sherry & Y Wu, Curr. Opin. Chem. Biol., 288, 2914-2922 (2013).

 “CEST: From basic principles to application, challenges and opportunities”, E Vinogradov, AD Sherry & RE Lenkinski, J. Magn. Reson., 229, 155-172 (2013).

 “Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical Shift Barcodes”, X Huang, G Huang, S Zhang, K Sagiyama, O Togao, Y Wang, Y Li, M Takahashi, AD Sherry & J Gao, Angew Chem Int Ed., 52, 8074-8078 (2013).

“A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI”, B Song, Y Wu, M Yu, P Zhao, C Zhou, GE Kiefer, & AD Sherry, Dalton Trans., 2013, 8066 - 8069.

“A Novel Class of Polymeric pH-Responsive MRI CEST Agents”, S Zhang, K Zhou, M Takahashi, AD Sherry, & J Gao, Chem. Commun., 49, 6418-6420 (2013).

 “Modulation of CEST Images in Vivo by T1 Relaxation: A New Approach in the Design of Responsive PARACEST Agents”, SJ Ratnakar, TC Soesbe, L Lumata, QN Do, S Viswanathan, C-Y Lin, AD Sherry & Z Kovacs, J Amer Chem Soc, 135, 14904-14907 (2013).

 “The stereochemistry of amide side-chains containing carboxyl groups influences water exchange rates in EuDOTA-tetraamide complexes”, T Mani, ACL Opina, P Zhao, M Evbuomwan, N Milburn, G Tircso, C Kumas & AD Sherry, J Biol Inorg Chem, 19, 161-171 (2014).

Updated: February 18, 2014

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