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These MRI maps show the pH distribution across the kidneys of a live mouse during renal clearance of a pH sensitive gadolinium contrast agent.

Imaging Projects

“Toward the Design of MR Agents for Imaging -cell Function”, M Woods, S Zhang & AD Sherry, Curr. Med. Chem. – Immun., Endocrine. & Metabolic Agents, 4, 349-369 (2004).

“Cyclen-based phenylboronate ligands and their Eu3+- complexes for sensing glucose by MRI”, R Trokowski, S Zhang & AD Sherry, Bioconj. Chem., 15, 1431-1440 (2004).

“A numerical solution of the Bloch equations provides insights into the optimal design of PARACEST agents for MRI”, DE Woessner, S Zhang, ME Merritt & AD Sherry, Magn. Reson. Med., 53, 790-799 (2005).

“On Resonance Low B1 Pulses for Imaging of the Effects of PARACEST Agents”, E Vinogradov, S Zhang, A Lubag, JA Balschi, AD Sherry and RE Lenkinski, J. Magn. Reson., 176, 54-63 (2005).

“High Resolution pHe Imaging of Rat Glioma using pH-dependent relaxivity”, ML Garcia-Martin, GV Martinez, N Raghunand, AD Sherry, S Zhang & RJ Gillies, Magn. Reson. Med., 55, 309-315 (2006).

“Catalytic effects of apoferritin interior surface residues on water exchange in lanthanide complexes”, O Vasalatiy, P Zhao, S Zhang, S Aime & AD Sherry, Contrast Media & Mol Imaging, 1, 1-5 (2006).

“Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging”, M Woods, DE Woessner & AD Sherry, Chem Soc Rev, 35, 500-511 (2006).

“Paramagnetic Lanthanide Complexes as PARACEST Agents for Medical Imaging”, M Woods, DE Woessner & AD Sherry, Chem Soc Rev, 35, 500-511 (2006).
“Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems”, N Nasongkla, E Bey, J Ren, H Ai, C Khemtong, JG Setti, SF Chin, AD Sherry, DA Boothman, J Gao, Nano Letters, 6, 2427-2430 (2006).

“PARACEST agents for Molecular Imaging” in Molecular & Cellular MR Imaging, Edited by J Bulte & M Modo, AD Sherry & M Woods, CRC Press, Chapter 6, pp. 101-122 (2007).
“MRI Detection of Glycogen In Vivo Using Chemical Exchange Saturation Transfer Imaging (glycoCEST)”, PCM van Zijl, CK Jones, J Ren, CR Malloy & AD Sherry, Proc. Natl. Acad. Sci., USA, 104, 4359-4364 (2007).
“Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications”, C Adair, M Woods, P Zhao, A Pasha, PM Winter, GM Lanza, P Athey, AD Sherry, GE Kiefer, Contrast Media & Molecular Imaging  2, 55-58 (2007).
“MRI detection of Paramagnetic Chemical Exchange Effects in mice kidneys in vivo”, E. Vinogradov, H He, A Lubag, JA Balschi, AD Sherry & RE Lenkinski, Magn Reson Med., 58, 650-655 (2007).  
“Albumin-binding PARACEST Agents”, MM Ali,  M Woods, EH Suh, Z Kovacs, G Tircsó, P Zhao, V Kodibagkar & AD Sherry, J. Biol. Inorg. Chem., 12, 855-865 (2007).
“Modulation of Water Exchange in Europium(III) DOTA-tetraamide Complexes via Electronic Substituent Effects”, SJ Ratnakar, M Woods, AJM Lubag, Z Kovács & AD Sherry, J. Amer. Chem. Soc., 130, 6-7 (2008).
“Labeling of Adenovirus Particles with PARACEST Agents”, O Vasalatiy, R Gerard, P Zhao, X Sun & AD Sherry, Bioconj. Chem., 19, 598-606 (2008).
“The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain”, K Hanaoka, AJM Lubag, A Castillo-Muzquiz, T Kodadek & AD Sherry, J. Magn. Reson. Imaging, 26, 608-617 (2008).
“Advances in molecular imaging of pancreatic beta cells”, M Lin, A Lubag, MJ McGuire, SY Seliounine, EN Tsyganov, PP Antich, AD Sherry, KC Brown & X Sun, Frontiers in Bioscience, 13, 4558-4575 (2008).
“Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes”,  JM Zhao, Y Har-el, MT McMahon, J Zhou, AD Sherry, G Sgouros, JW Bulte, PCM van Zijl,   J. Amer. Chem. Soc., 130, 5178-5184 (2008).
“Synthesis and Relaxometric Studies of a Dendrimer-Based pH-Responsive MRI Contrast Agent”, MM Ali, M Woods, P Caravan, ACL Opina, M Spiller, JC Fettinger & AD Sherry, Chem. Eur. J., 14, 7250-7258 (2008).
“Imaging the Tissue Distribution of Glucose in Liver using a PARACEST Sensor”, J Ren, S Zhang,  R Trokowski, C Storey, A Milde, CR Malloy & AD Sherry, Magn. Reson. Med., 60, 1047-1055 (2008).
“Chemical Exchange Saturation Transfer Contrast Agents for Magnetic Resonance Imaging”. AD Sherry & M Woods, Ann. Rev. Biomed. Eng., 10, 391-411 (2008).

“Polymeric PARACEST Agents for Enhancing MRI Contrast Sensitivity”, Y Wu, Y Zhou, O Ouari, M Woods, P Zhao, TC Soesbe, GE Kiefer & AD Sherry, J. Amer. Chem. Soc., 130, 13854-13855 (2008).
“In vivo Off-Resonance Saturation Magnetic Resonance Imaging of avb3-Targeted Superparamagnetic Nanoparticles”, C Khemtong, CW Kessinger, J Ren, EA Bey, S-G Yang, JS Guthi, DA Boothman, AD Sherry & J Gao, Cancer Res., 69, 1651-1658 (2009).
“A New Gadolinium-based MRI Zinc Sensor”, AC Esqueda, JA López, G Andreu-de-Riquer, JC Alvarado-Monzón, J Ratnakar, AJM Lubag, AD Sherry & LM De León-Rodríguez, J. Amer. Chem. Soc., 131, 11387-11391 (2009).

“Modulation of Water Exchange in EuDOTA-tetraamide Complexes: Considerations for in vivo Imaging of PARACEST Agents”, T Mani, G Tircsó, O Togao, P Zhao, T Soesbe, M Takahashi & AD Sherry, Contrast Media & Mol Imaging, 4, 183-191 (2009).

“Responsive MRI agents for sensing metabolism in vivoLM De Leon-Rodriguez, AJM Lubag, CR Malloy, GV Martinez, RJ Gillies & AD Sherry, Accts. Chem. Res., 42, 948-957 (2009).
“The Effect of the Regiochemistry of Butyl Amide Substituents on the Solution-State Structures of Lanthanide(III) DOTA-tetraamide complexes”, T Mani, M Woods, P Zhao, G Tircsó & AD Sherry, Inorg. Chem., 48, 10338-10345 (2009).

“Nanoassembled Capsules as Delivery Vehicles for Large Payloads of High Relaxivity Gd3+ Agents”,  SE Plush, M Woods, Y Zhou, SB Kadali & MS Wong, J. Amer. Chem. Soc., 131, 15918-15923 (2009).
“Multi-Frequency PARACEST Agents Based on Europium(III)-DOTA-Tetraamide Ligands”, S Viswanathan, SJ Ratnakar, KN Green, Z Kovacs, LM De León & AD Sherry, Angew. Chem. Int. Ed., 48, 9330-9333 (2009).
“A Multislice Gradient Echo Pulse Sequence for CEST Imaging”, WT Dixon, I Hancu, SJ Ratnaker, AD Sherry, RE Lenkinski & DC Alsop, Magn. Reson. Med., 63, 253–256 (2010).

“A Concentration-Independent Method to Measure Exchange Rates in PARACEST Agents”, WT Dixon, J Ren, J Ratnakar, E Vinogradov, RE Lenkinski & AD Sherry, Magn. Reson. Med., 63, 625-632 (2010).

 “A Multislice Gradient Echo Pulse Sequence for CEST Imaging”, WT Dixon, I Hancu, SJ Ratnaker, AD Sherry, RE Lenkinski & DC Alsop, Magn. Reson. Med., 63, 253–256 (2010).
“Bimodal MR-PET Agent for Quantitative pH Imaging”, L Frullano, C Catana, T Benner, AD Sherry & P Caravan, Angew. Chem. Int. Ed., 49, 2382-2384 (2010).      

“A Responsive Europium(III) Chelate that Provides a Direct Readout of pH by MRI”, Y Wu, TC Soesbe, GE Kiefer, P Zhao & AD Sherry, J. Amer. Chem. Soc., 132, 14002-14003 (2010).  

“MRI Detection of VEGFR2 in vivo Using a Low Molecular Weight Peptoid-(Gd)8-Dendron for Targeting”, LM DeLeon-Rodriquez, A Lubag, DG Udugamasooriya, B Proneth, RA Brekken, X Sun, T Kodadek & AD Sherry, J. Amer. Chem. Soc., 132, 12829-12831 (2010).   

"Off-Resonance Saturation MRI of Superparamagnetic Nanoprobes: Theoretical Models and Experimental Validations"  C Khemtong, O Togao, J Ren, C Kessinger, M Takahashi, AD Sherry & J Gao, J. Magn. Reson., 209, 53–60 (2011). 

“T2 Exchange Agents: A New Class of Paramagnetic MRI Contrast Agent that Shortens Water T2 by Chemical Exchange Rather than Relaxation”, TC Soesbe, ME Merritt, KN Green, FA Rojas-Quijano & AD Sherry, Magn. Reson. Med., 66, 1697-1703 (2011).  

“Imaging the Extracellular pH of Tumors by MRI after Injection of a Single Cocktail of T1 and T2 Contrast Agents”, GV Martinez, X Zhang, ML García-Martín, DL Morse, M Woods, AD Sherry & RJ Gillies, NMR in Biomed., 24, 1380-1391 (2011).

“Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent”,  AJ Lubag,  LM De Leon-Rodriguez, SC Burgess, &AD Sherry, Proc. Natl. Acad. Sci. USA,  108, 18400-18405 (2011). 

“In Vivo Determination of Human Breast Fat Composition by 1H Magnetic Resonance Spectroscopy at 7T”. IE Dimitrov, D Douglas D, J Ren, NB Smith, AG Webb, AD Sherry, & Malloy CR,  Magn Reson Med., 67:20-26 (2012).  

“Using frequency-labeled exchange (FLEX) transfer to separate out conventional magnetization transfer effects from exchange transfer effects when detecting PARACEST agents”, C-Y Lin, NN Yadav, JI Friedman, J Ratnakar, AD Sherry, PCM van Zijl, Magn Reson Med, 67, 906-911 (2012).

“SWIFT-CEST:  A New Method to Overcome T2 Shortening Caused by PARACEST Contrast Agents”, TC Soesbe, O Togao, M Takahashi & AD Sherry, Magn. Reson. Med., 68, 816-821 (2012).

“Fast dissolution dynamic nuclear polarization NMR of 13C-enriched 89Y-DOTA complex:  Experimental and theoretical considerations”, L Lumata, ME Merritt, CR Malloy, AD Sherry & Z Kovacs, Appl. Magn. Reson., 43, 69-79 (2012).

"Impact of Gd3+ on DNP of [1-13C]Pyruvate Doped with Trityl OX063, BDPA, or 4-oxo-TEMPO", L Lumata, ME Merritt, CR Malloy, AD Sherry & Z Kovács, J. Phys. Chem. A, 116, 5129-5138 (2012).

“Molecular Imaging and Cancer Management: PET and MR Agents for Molecular Imaging of Cancer Metabolism”, Y Wu, X Sun & AD Sherry, in Principles of Molecular Diagnostics and Personalized Cancer Medicine, edited by Dongfeng Tan, MD, and Henry Lynch, MD, Lippincott, Williams & Wilkins, Philadelphia, 2012, Chapter 20, pp. 233-246.

 “Imaging free zinc levels in vivo – what can be learned?”, L DeLeon-Rodriquez, AJM Lubag & AD Sherry, Inorganica Chemica Acta, 393, 12-23 (2012).

“Dynamic Monitoring of Carnitine and Acetylcarnitine in the Trimethylamine Signal after Exercise in Human Skeletal Muscle by 7T 1H MRS, J Ren, S Lakoski, RG Haller, AD Sherry & CR Malloy, Magn Reson Med, 69, 7-17 (2013).
“Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP”, L Lumata, Z Kovacs, AD Sherry, CR Malloy, S Hill, J van Tol, L Yu, L Song & ME Merritt, Physical Chemistry Chemical Physics, 15, 9800-9807 (2013).

“Noninvasive Monitoring of Lactate Dynamics in Human Forearm Muscle after Exhaustive Exercise by 1H Magnetic Resonance Spectroscopy at 7 Tesla”, J Ren, AD Sherry & CR Malloy, Magn Reson Med, 70, 610-619 (2013).

"Characterization of lung cancer by amide proton transfer (APT) imaging: An in-vivo study in an orthotopic mouse model", PLOS one, O Togao, CW Kessinger, G Huang, TC Soesbe, K Sagiyama, I Dimitrov, AD Sherry, J Gao & M Takahashi, PLoS One 2013 Oct 15;8(10):e77019.

“APT imaging allows early detection of therapeutic response of glioblastoma to chemotherapy”, K Sagiyama, T Mashimo, O Togao, V Vemireddy, KJ Hatanpaa, MA Maddie, EA Maher, AD Sherry, RM Bachoo, & M Takahashi, PNAS, in press.

“Alternatives to Gadolinium-based MRI Metal Chelates”, S. Viswanathan, Z. Kovacs, SJ Ratnakar, KN Green & AD Sherry, Chemical Reviews, in press.

Updated: February 12, 2014

©2006 The University of Texas at Dallas