Treasures @ UT Dallas
Welcome to Treasures @ UT Dallas Institutional Repository, established in 2010. Treasures is a resource for our community to showcase, organize, share, and preserve research and scholarship in an Open Access repository.
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Recent Submissions
Controllability, Reachability, and Inference for Complex Dynamic Systems
(December 2022) Hadizadeh Kafash, Sahand 1989-; Ruths, Justin; Varner, Victor; Spong, Mark W.; Waseem Abbas; Zare, Armin; Koeln, Justin
The focus of this dissertation is on developing a data-driven framework to infer interconnections in networks of dynamic agents, development of theoretical foundations for the controllability of bilinear systems, and reachability analysis of linear time invariant systems.
Inspired by some existing methodologies on discovering the governing dynamics using time-
series data, here we introduce two new data manipulation techniques that can be applied to
infer interconnections when the agents are of the second-order dynamics and have hidden
states, the states not available for direct measurements. In the next step, the controllability
of single-input bilinear systems is investigated. It will be shown that some of the conditions
required for the controllability of such systems can be relaxed at the expense of losing control over regions with zero Lebesgue measures in the state space. We then show how these
relaxations can open path to achieve conditions on the near controllability of multi-input
bilinear systems. Lastly, the reachability problem is studied for discrete-time linear systems
where we propose new techniques for verifying the inclusion and exclusion of given sets with
applications to the security of cyber-physical systems.
Paths to Non-ergodic Quantum Dynamics: From Cavity QED to Strong Zero Modes
(December 2022) Rahmanian Koshkaki, Saeed; Pereira, Luis Felipe; Kolodrubetz, Michael; Lv, Bing; Vandenberghe, William; Zhang, Fan; Zhang, Chuanwei
Recent advances in cold atoms experiments and the development of superconducting circuits have revolutionized the way we can examine, observe and implement new physical
phenomena. In such systems, we can realize new classes of quantum systems which exhibit
non-equilibrium quantum phenomena. These systems have attracted mcuh attention in
the past two decades as they possess new physics absent in equilibrium. Beside interesting rich physics to learn more about quantum systems, understanding non-equilibrium
systems are crucial in developing future technologies such as quantum computation and
communication.
Given that many open questions needed to be answered in the study of non-equilibrium
quantum systems, in this dissertation we will present our theoretical and numerical attempts in providing answers to some of these questions. One of the key features of the
non-equilibrium system is how the dynamical properties of quantum systems cane be
characterized in different conditions. Here we will present our result on two different
mechanism a system can avoid ergodicity.
Many-body localization (MBL) is an extension of Anderson localization to interacting systems, where adding strong enough disorder (breaking translational symmetry by adding
random potential such as impurity in crystals) can impede the conductivity (system
becomes insulator) in the quantum system. Most of the known MBL systems are short-
range interacting particles, but in this dissertation, we will discuss MBL in the presence
of coupling of the matter to cavity/circuit QED mode where the combined system becomes long-range interacting. We will study the two cases of weak coupling and strong
coupling regimes and will derive the effective Hamiltonian using the high-frequency expansion for each case of coupling strength. We predict that the cavity QED has new
localization behaviors such as an inversion of the mobility edge where the high-energy
states are localized and low-energy states are delocalized. Also in the strong coupling
limit, we observed that using the idea from coherent destruction of coupling the system
can show signs of localization for photon number as low as n ∼ 2.
The rest of this dissertation is devoted to understanding how a clean system (no disorder)
can possess symmetry-breaking edge modes indefinitely, or for a long enough but finite
time. The case with infinite lifetime edge mode is called strong mode (SM) and the
case with finite lifetime edge mode is known as almost strong mode (ASM). Our system
of interest is a clock Z3 model which is an extension of the Ising Z2 models. In the
clock model (Baxter and modified Baxter) we found that the chirality of the interaction
is essential in deriving the exact edge mode in the Hermitian model but removing the
hermiticity (controlled by a parameter β), the effect of chirality on the stability of the edge
mode becomes less important. We attempt to use different numerical and approximation
techniques such as Krylov Hamiltonian and dynamical signature to characterize the edge
mode in a Z3 model.
Synthesis and Bioactivity Evaluation of KDM4 Inhibitors in Prostate Cancer Cells
(December 2022) Smith, Tristan; Ahn, Jung Mo; Penev, Kaloyan; Smaldone, Ronald A.; D'Arcy, Sheena; Stefan, Mihaela C.
The need for alternative therapeutic targets has grown due to the stagnating progress of treatment
for metastatic prostate cancer with activity independent of the androgen receptor. Inhibition of
histone lysine demethylases belonging to the KDM4 subfamily are of significant interest due to
their aberrant expression and role in castration-resistant prostate cancer. This dissertation presents
the design, synthesis, and biochemical evaluation for a library of 8-hydroxyquinoline-based
derivatives of B3, a KDM4 inhibitor that has previously demonstrated therapeutic potential.
Motivated by the search for improved efficacy for KDM4 inhibition in prostate cancer, the first
investigation highlights the structure-activity relationship discovered from modifying the
phenylpropyl moiety of B3. Screening a comprehensive list of different chemical groups revealed
several with improved inhibitor activity and stability. Continuing our search for improved efficacy,
the second investigation explored augmentation of the benzamide moiety of B3 that led to the
identification of a new lead inhibitor using 4-(3-methoxypropyl)morpholine. This modification to
B3 led to the desired cytotoxicity to tumor viability during in vitro MTT assays and in vivo murine
studies.
An Asian American Cookbook: the 汤圆(Tang Yuan) Chocolate Chip Cookie
(December 2023) Banditrat, Emily 05/30/1996-; Farrar, Eric; Johnson, Casey; Terry, Dean
The 汤圆(Tang Yuan) Chocolate Chip Cookie is a three-dimensional diorama that captures and
guides viewers through the process of combining two drastically different ethnic desserts into
one final product. Through a video presentation of the diorama, this project is designed so that
each part of the 3D environment contains hints and clues about the baker's identity. It aims to
introduce readers to embark on a treasure hunt to piece together the story of this new cookie and
how it came into existence.
By employing dynamic composition with baking ingredients, the implied motion directs the
reader's gaze towards key elements of the baking environment. The scene's composition and prop
placement begin with the camera opening to the center of the room and progressing to display
the cooking process from left to right. A slow pan captures the viewer's attention, allowing them
to explore the baker's story elements scattered throughout the kitchen.
Home-based Lower Limb Immersive Serious Game for Phantom Pain Management
(December 2023) Chung, Yu-Yen 1987-; Prabhakaran, Balakrishnan; Rotea, Mario A.; Kim, Jin Ryong; Xiang, Yu; Guo, Xiaohu
With recent advances in mixed reality technology, Head Mounted Devices (HMDs) have
become a preferred option for immersive gaming at home. Immersive games using HMD have
been applied for serious purposes, such as improving motivation for performing rehabilitation
activities at home. Mr.MAPP is a virtual mirror therapy system designed for amputees with
phantom limb pain. In this work, we first investigate the Mr.MAPP system through a clinical
patient study and further improve the system design based on the uncovered insight. In
addition, to allow users to experience mixed reality in the first-person perspective using their
realistic body reconstruction, we prototype a system to aggregate the body’s texture in realtime.
Through simulation using the reconstruction system, we created an optimal camera
setup guideline for amputees’ in-home setup. Lastly, a Home-based Lower Limb Immersive
Exergame System (HILLES) is developed to address challenges such as system setup, safety,
and game engagement for in-home usage. A stomping game using the system is developed
for an exploratory user study to evaluate the system and the proposed enhancements. The
discovered insight could be helpful for future lower limb exergame design.