Texas Biomedical Device Center


FDA Approves Two Clinical Trials Using the ReStore Vagus Nerve Stimulator
ReStore Vagus Nerve Stimulator
The Texas Biomedical Device Center (TxBDC) at The University of Texas at Dallas received FDA approval to proceed with two early feasibility studies using the ReStore Vagus Nerve Stimulator. The first study will use ReStore to enhance recovery following a spinal cord injury. The second study will use ReStore to enhance prolonged exposure therapy for treating Post Traumatic Stress Disorder (PTSD).
Read more about the SCI Study
Read more about the PTSD Study
Peripheral Nerve Recovery
In the News
Study: VNS Shows Promise for Improving Peripheral Nerve Recovery

When a nerve in an arm or leg is damaged, the brain adapts rapidly to the suddenly missing signal from that part of the body. This reaction complicates later efforts at rehabilitation. In an effort to restore function after peripheral nerve injury, researchers at The University of Texas at Dallas have demonstrated in an animal model that sparking change in the central nervous system during physical rehabilitation enhances recovery. Read more

Vagus Nerve Stimulation for Stroke Recovery
In the News
UT Dallas Develops New Device To Help Stroke Victims

The University of Texas at Dallas is developing a new device to help stroke victims. The wireless device is a tiny piece of glass that sits on the vagus nerve in the neck. It helps release chemicals in the brain that can help the person recover faster. Dr. Robert Rennaker, professor of engineering and neuroscience and the Texas Instruments Distinguished Chair in Bioengineering, helped create the device. Listen now

Dr. Robert Rennaker and Dr. Seth Hays
Research Support
Grant Brings Nerve Stimulation Device Closer to Next Stage of Testing

Bioengineering researchers at The University of Texas at Dallas recently received a $1.4 million grant from the National Institutes of Health to study the use of wireless vagus nerve stimulation (VNS) to enhance recovery after stroke. Read more

One Device, Unlimited Possibilities with ReStore
Tinnitus Relief
See how researchers at the Texas Biomedical Device Center are using the Restore vagus nerve stimulator to help brain injury patients fully reengage in life. This therapy uses stimulation of the vagus nerve during rehabilitation to rewire neural circuits, dramatically improving recovery. TxBDC researchers are at the forefront of investigations into neuroplasticity and its role in the development of a wide range of therapies for disorders including stroke, tinnitus, traumatic brain injury, PTSD, and peripheral nerve injury. Watch the video


March 30, 2019 | bioRxiv
Flat Electrode Contacts for Peripheral Nerve Stimulation

April 11, 2019 | Journal of NeuroEngineering and Rehabilitation
A suite of automated tools to quantify hand and wrist motor function after cervical spinal cord injury

April 23, 2019 | The International Journal on the Biology of Stress
Vagus nerve stimulation reverses the extinction impairments in a model of PTSD with prolonged and repeated trauma

June 7, 2019 | Experimental Neurology
Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

June 19, 2019 | Journal of Neurophysiology
Pairing vagus nerve stimulation with tones drives plasticity across the auditory pathway

July 4, 2019 | Experimental Brain Research
Quantitative assessment of cortical somatosensory digit representations after median and ulnar nerve injury in rats

November 13, 2019 | Journal of Affective Disorders
Vagus nerve stimulation produces immediate dose-dependent anxiolytic effect in rats

November 18, 2019 | PLOS
Flat electrode contacts for vagus nerve stimulation

December 19, 2019 | Progress in Neuropsychopharmacology & Biological Psychiatry
Efficient parameters of vagus nerve stimulation to enhance extinction learning in an extinction-resistant rat model of PTSD

December 19, 2019 | Nature Communications
Enhancing plasticity in central networks improves motor and sensory recovery after nerve damage

December 25, 2019 | Annals of Neurology
Restoration of somatosensory function by pairing vagus nerve stimulation with tactile rehabilitation

January 1, 2020 | Journal of Neurotrauma
Acute Cardiovascular Responses to Vagus Nerve Stimulation Following Experimental Spinal Cord Injury

January 22, 2020 | Neurorehabilitation and Neural Repair
Vagus Nerve Stimulation Paired With Rehabilitative Training Enhances Motor Recovery After Bilateral Spinal Cord Injury to Cervical Forelimb Motor Pools

April 4, 2020 | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Efficient parameters of vagus nerve stimulation to enhance extinction learning in an extinction-resistant rat model of PTSD

May, 2020 | Experimental Neurology
Parametric characterization of the rat Hering-Breuer reflex evoked with implanted and non-invasive vagus nerve stimulation

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Texas Biomedical Device Center
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800 W. Campbell Road, BSB | Richardson, Texas 75080 [email protected]

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