Research

Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline. Thorn CA, Moon J, Bourbonais CA, Harms J, Edgerton JR, Stark E, Steyn SJ, Butter CR, Lazzaro JT, O'Connor RE, Popiolek M. 2019; ACS Chemical Neuroscience. 2019 Mar 20;10(3):1753-1764. PMID: 30480428.

Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer’s disease. Lebois EP, Thorn C, Edgerton JR, Popiolek M, Xi S. Neuropharmacology. 2018 Jul 1;136(Pt C):362-373; PMID: 29138080.

Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity. Davoren JE, Garnsey M, Pettersen B, Brodney MA, Edgerton JR, Fortin JP, Grimwood S, Harris AR, Jenkinson S, Kenakin T, Lazzaro JT, Lee CW, Lotarski SM, Nottebaum L, O'Neil SV, Popiolek M, Ramsey S, Steyn SJ, Thorn CA, Zhang L, Webb D. Journal of medicinal chemistry. 2017; 60(15):6649-6663. PMID: 28598634.

Effects of M1 and M4 activation on excitatory synaptic transmission in CA1. Thorn CA, Popiolek M, Stark E, Edgerton JR. Hippocampus. 2017; 27(7):794-810. PMID: 28422371 PMCID: PMC5573954.

Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice. Sherman MA, Lee S, Law R, Haegens S, Thorn CA, Hämäläinen MS, Moore CI, Jones SR. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(33):E4885-94. PMID: 27469163 PMCID: PMC4995995.

Differential entrainment and learning-related dynamics of spike and local field potential activity in the sensorimotor and associative striatum. Thorn CA, Graybiel AM. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2014; 34(8):2845-59. PMID: 24553926 PMCID: PMC3931500.

Temporal and mosaic Tsc1 deletion in the developing thalamus disrupts thalamocortical circuitry, neural function, and behavior. Normand EA, Crandall SR, Thorn CA, Murphy EM, Voelcker B, Browning C, Machan JT, Moore CI, Connors BW, Zervas M. Neuron. 2013; 78(5):895-909. NIHMSID: NIHMS463956 PMID: 23664552 PMCID: PMC4529124.

Pausing to regroup: thalamic gating of cortico-basal ganglia networks. Thorn CA, Graybiel AM. Neuron. 2010; 67(2):175-8. PMID: 20670826.

Differential dynamics of activity changes in dorsolateral and dorsomedial striatal loops during learning. Thorn CA, Atallah H, Howe M, Graybiel AM. Neuron. 2010; 66(5):781-95. NIHMSID: NIHMS294217 PubMed [journal] PMID: 20547134 PMCID: PMC3108575.

Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task. Tort AB, Kramer MA, Thorn C, Gibson DJ, Kubota Y, Graybiel AM, Kopell NJ. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(51):20517-22. PMID: 19074268 PMCID: PMC2629291.

Oscillations of local field potentials in the rat dorsal striatum during spontaneous and instructed behaviors. DeCoteau WE, Thorn C, Gibson DJ, Courtemanche R, Mitra P, Kubota Y, Graybiel AM. Journal of Neurophysiology. 2007; 97(5):3800-5. PMID: 17329629.

Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task. DeCoteau WE, Thorn C, Gibson DJ, Courtemanche R, Mitra P, Kubota Y, Graybiel AM. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(13):5644-9. PMID: 17372196 PMCID: PMC1838454.